How many US obstetrical trials reach publication? A cross-sectional analysis of ClinicalTrials.gov and PubMed from 2007 to 2019

DiTosto, Julia D.; Steinberg, Jecca R.; Turner, Brandon E.; Weeks, Brannon T.; Young, Ann; Lu, Connie Fei; Wolgemuth, Tierney; Holder, Kai; Laasiri, Nora; Squires, Natalie; Anderson, Jill N.; ZHANG, Naixin; Richardson, Michael; Magnani, Christopher J.; PERRY, Madeline F.; Yee, Lynn M.

doi:10.1016/j.ajogmf.2022.100696

Cited by 6 publications

(1 citation statement)

References 42 publications

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“…The methods to select trials and publications and to characterize trial foci were described previously. 13 , 14 This study of publicly available data was exempted from IRB oversight. The study design met STROBE (Strengthening the Reporting of Observational Studies in Epidemiology) guidelines.…”

Section: Methodsmentioning

confidence: 99%

Obstetric Clinical Trial Diversity

Steinberg,

DiTosto,

Turner

et al. 2023

Obstetrics &Amp; Gynecology

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Inclusive clinical trials are necessary to improve maternal health equity. We aimed to analyze the current state of race and ethnicity reporting and representation in obstetric trials and the association with trial focus for all U.S.-based obstetric trials between 2007 and 2020. In this cross-sectional, multivariable regression analysis, the exposure variable was clinical trial focus (eg, prematurity), and the outcomes were race and ethnicity reporting and representation of diverse cohorts. Obstetric anesthesia trials reported race and ethnicity the least frequently of all trial foci (adjusted odds ratio 0.2, 95% CI 0.08–0.48). Hypertension and obstetric anesthesia trials enrolled the lowest proportion of Black participants, and prematurity trials enrolled the lowest proportion of Latinx and Asian participants. All researchers should strive to improve measurement and reporting of demographic data as well participation of diverse cohorts.

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Section: Methodsmentioning

confidence: 99%