How Much Particle Surface Corrugation Is Sufficient to Improve Aerosol Performance of Powders?

Chew, Nora Y.K.; Tang, Patricia A.; Chan, Hak‐Kim; Raper, Judy A

doi:10.1007/s11095-004-9020-4

Cited by 197 publications

(123 citation statements)

References 23 publications

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“…As example, GISO3-leu15 formulations, containing 15% w/w of leu and obtained from 30% v/v of ISO/water feed, emitted 50.4 mg of fine G after one actuation of the Turbospin device. These results are in agreement with previous studies [29,30,53] evidencing the enhancement of powder aerosol performance as particle surface corrugation goes up to a certain degree; further corrugation enhancement did not improve aerodynamic properties. The plot in figure 13 allows to appreciate a dramatic increase in both particle corrugation (SEM micrographs) and FPF as the leu content increased.…”

Section: Aerodynamic Behavior Of G/leu Powderssupporting

confidence: 93%

“…In fact, previous reports suggested that improvement of the respirable fraction may be obtained not only by lowering the size or the density of a powder, but also reducing interparticulate cohesion [29,30]. Corrugated particles might also be more appropriate for dissolution in the lung fluid due to a larger area.…”

Section: Naringin Dry Powders Production and Characterizationmentioning

confidence: 99%

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Development and Investigation of Dry Powder Inhalers for Cystic Fibrosis

Russo¹,

Prota²,

Stigliani³

et al. 2012

Recent Advances in Novel Drug Carrier Systems

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Section: Aerodynamic Behavior Of G/leu Powderssupporting

confidence: 93%

Section: Naringin Dry Powders Production and Characterizationmentioning

confidence: 99%

Development and Investigation of Dry Powder Inhalers for Cystic Fibrosis

Russo¹,

Prota²,

Stigliani³

et al. 2012

Recent Advances in Novel Drug Carrier Systems

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“…Furthermore, formulation N2 showed a more regular spherical shape in the SEM than formulation C, which exhibited irregular morphology with extensive flat surfaces that may promote a large contact area and would result in increased adhesion between the particles. 41 This increase in adhesion may have reduced the redispersion abilities of the powder and the agglomeration of particles, which should also have increased the MMAD of the aerosol. Finally, the tapped density of formulation C was higher than that of formulation N2 (0.308 g/cm 3 and 0.230 g/cm 3 for formulations C and …”

Section: Evaluation Of Particle Size and In Vitro Lung Depositionmentioning

confidence: 99%

New inhalation-optimized itraconazole nanoparticle-based dry powders for the treatment of invasive pulmonary aspergillosis

Duret¹,

Wauthoz²,

Sebti³

et al. 2012

IJN

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Correspondence: Christophe Duret Université Libre de Bruxelles (ULB), Boulevard du triomphe campus de la plaine (accès 2), Service de pharmacie galénique et biopharmacie, bat BC niveau 6, Brussels, Belgium Tel +32 650 5331 Fax +32 650 5269 Email cduret@ulb.ac.be Purpose: Itraconazole (ITZ) dry powders for inhalation (DPI) composed of nanoparticles (NP) embedded in carrier microparticles were prepared and characterized. Methods: DPIs were initially produced by reducing the ITZ particle size to the nanometer range using high-pressure homogenization with tocopherol polyethylene 1000 succinate (TPGS, 10% w/w ITZ) as a stabilizer. The optimized nanosuspension and the initial microsuspension were then spray-dried with different proportions of or in the absence of mannitol and/or sodium taurocholate. DPI characterization was performed using scanning electron microscopy for morphology, laser diffraction to evaluate the size-reduction process, and the size of the dried NP when reconstituted in aqueous media, impaction studies using a multistage liquid impactor to determine the aerodynamic performance and fine-particle fraction that is theoretically able to reach the lung, and dissolution studies to determine the solubility of ITZ. Results: Scanning electron microscopy micrographs showed that the DPI particles were composed of mannitol microparticles with embedded nano-or micro-ITZ crystals. The formulations prepared from the nanosuspension exhibited good flow properties and better fine-particle fractions, ranging from 46.2% ± 0.5% to 63.2% ± 1.7% compared to the 23.1% ± 0.3% that was observed with the formulation produced from the initial microsuspension. Spray-drying affected the NP size by inducing irreversible aggregation, which was able to be minimized by the addition of mannitol and sodium taurocholate before the drying procedure. The ITZ NP-based DPI considerably increased the ITZ solubility (58 ± 2 increased to 96 ± 1 ng/mL) compared with that of raw ITZ or an ITZ microparticle-based DPI (,10 ng/mL). Conclusion: Embedding ITZ NP in inhalable microparticles is a very effective method to produce DPI formulations with optimal aerodynamic properties and enhanced ITZ solubility. These formulations could be applied to other poorly water-soluble drugs and could be a very effective alternative for treating invasive pulmonary aspergillosis.

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“…Beside conventional spherical particles, spray drying permits also the controlled production of particles of different morphology. Corrugated particles can be attained, for example, by changing the spray drying process conditions [55][56][57], by employing polymeric excipients like dextran to increase the solution viscosity [58] or by adding low soluble components like leucine and trileucine [59][60][61]. These particles have a lower density and thus a larger geometrical size which improves powder dispersibility due to higher drag forces in the air stream.…”

Section: Engineered Particlesmentioning

confidence: 99%