How polysulfone dialysis membranes containing polyvinylpyrrolidone achieve excellent biocompatibility?

Hayama, Masayo; Yamamoto, Ken; Kohori, Fukashi; Sakai, Kiyotaka

doi:10.1016/j.memsci.2004.01.020

Cited by 160 publications

(105 citation statements)

References 18 publications

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“…Platelet adhesion on the surface of the membranes is dependent on not only hydrophilicity, but also on the surface structure [8]. Platelet adhesion is reduced as the result of a ''cushion effect'' when wet PVP particles are uniform and soft.…”

Section: Introductionmentioning

confidence: 99%

Poly(N-vinyl-2-pyrrolidone) elution from polysulfone dialysis membranes by varying solvent and wall shear stress

et al. 2012

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Some dialysis patients are treated with post-hemodiafiltration (HDF); the blood viscosity of the patients who undergo post-HDF is higher than that of the patients who undergo conventional hemodialysis. This study aims to evaluate poly(N-vinyl-2-pyrrolidone) (PVP) elution from PSf dialysis membranes by varying solvents and high wall shear stress caused by blood viscosity. We tested three commercial membranes: APS-15SA (Asahi Kasei Kuraray), CX-1.6U (Toray) and FX140 (Fresenius). Dialysate and blood sides of the dialyzers were primed with reverse osmosis (RO) water and saline. RO water, saline and dextran solution (2.9 and 5.8 mPa s) were circulated in the blood side. The amount of eluted PVP was determined by 0.02 N iodometry. The hardness and adsorption force of human serum albumin (HSA) on the membrane surfaces were measured by the atomic force microscope. When wall shear stress was increased using dextran, the amount of PVP eluted by the 2.9 mPa s solution equaled that eluted by the 5.8 mPa s solution with APS-15SA and CX-1.6U sterilized by gamma rays. The amount of PVP eluted by the 5.8 mPa s solution was higher than that eluted by the 2.9 mPa s solution with FX140 sterilized by autoclaving. The wall shear stress increased the PVP elution from the surface, hardness and adsorption force of HSA. Sufficient gamma-ray irradiation is effective in decreasing PVP elution.

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Section: Introductionmentioning

confidence: 99%

Poly(N-vinyl-2-pyrrolidone) elution from polysulfone dialysis membranes by varying solvent and wall shear stress

et al. 2012

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“…4,5,9 Among the different polymeric materials that are used for the preparation of phase-inversion membranes, cellulose acetate (CA) is very common, with characteristics such as good toughness, high biocompatibility, good desalting, high potential flux, and relatively low cost. [11][12][13][14] Thus, it has been widely used for reverse osmosis, microfiltration, and gas separation. 15,16 Also, CA membranes have excellent hydrophilicity, which is very important in the minimization of fouling.…”

Section: Introductionmentioning

confidence: 99%

Effect of poly(vinyl pyrrolidone) concentration and coagulation bath temperature on the morphology, permeability, and thermal stability of asymmetric cellulose acetate membranes

Saljoughi

Amirilargani

Mohammadi

2008

J of Applied Polymer Sci

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Cellulose acetate (CA) is widely used in membrane processes. In this study, CA (weight-average molecular weight ¼ 52,000) was mixed with poly(vinyl pyrrolidone) (PVP; weight-average molecular weight ¼ 15,000) as an additive in 1-methyl-2-pyrrolidone as a solvent. The phase-inversion method was used for the preparation of flat-sheet membranes. The effects of PVP concentration and coagulation bath temperature (CBT) on the morphology, pure water permeation flux, and thermal stability of the prepared membranes were studied and are discussed in this article. The solute rejection of the developed CA membranes was quantified with an insulin protein solution. The results showed that an increase in the CBT levels from 0 to 23C along with an increase in the PVP concentration in the cast film from 0 to 1.5 wt % resulted in an increase in the macrovoid formation in the membrane sublayer, an increase in the pure water flux (PWF), and a decrease in insulin rejection. Further increases in the PVP concentration from 1.5 to 3, 6, and 9 wt % resulted in gradual suppression of the macrovoid formation, a decrease in PWF, and an increase in insulin rejection. Higher PVP concentrations and lower CBT levels also appeared to result in higher glass-transition temperatures.

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“…Polysulfone is engineering plastic with high mechanical strength and ductility and limited biocompatibility. However, its blends with hydrophilic and biocompatible components, such as poly(N-vinyl-2-pyrrolidone) (PVP), show significantly enhanced biocompatibility [64]. Immobilisation of lipase onto the polysulfone-based electrospun nanofibres through physical adsorption was achieved using PVP or PEG as additives [44].…”

Section: Enzyme Immobilisationmentioning

confidence: 99%

Electrospinning-Based Nanobiosensors

Cesare

Macagnano

2015

Electrospinning for High Performance Sensors

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Biological interactions in biosensors occur through different mechanisms, on the basis of the type of biological receptor elements employed therein that confer the biological specificity to the biosensors themselves (biocatalytic, biocomplexing or bioaffinity biosensors). The use of different transduction systems (amperometric, potentiometric, field-effect transistors, piezometric and conductometric) defines the mode of detection. The interest and relevance of nanomaterials in the fabrication of nanobiosensors lie in their extraordinary properties that make them ideally suited and very promising for sensing applications. The resulting nanobiosensors are capable of sensing analytes in traces with fast, precise and accurate biological identification through miniaturised and easy to use systems. These advanced sensors are also characterised by lower detection limits, higher sensitivity values and high stability, and can further offer multi-detection possibilities. These exceptional features make nanobiosensors as the favourite tools in quality control, food safety, and traceability for their capacity of revealing and warning people against the presence of pathogens, toxins and pollutants, as well as bioterrorism agents. Despite the outstanding properties of these nanobiosensors, however, the efficiency of the biorecognition agent and the number of biorecognition sites available for interacting with target analytes can limit the sensitivity of this kind of sensors. The number of available biorecognition sites is directly related to the surface area of the sensor. Electrospinning technology can significantly increase the sensitivity of biosensors by replacing the typical planar interactive surface of conventional biosensors with a mat of electrospun nonwoven nanofibres, thereby taking advantage of the ultrahigh surface area offered by electrospun nanofibres. Moreover, adjusting the electrospinning process to produce

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How polysulfone dialysis membranes containing polyvinylpyrrolidone achieve excellent biocompatibility?

Cited by 160 publications

References 18 publications

Poly(N-vinyl-2-pyrrolidone) elution from polysulfone dialysis membranes by varying solvent and wall shear stress

Poly(N-vinyl-2-pyrrolidone) elution from polysulfone dialysis membranes by varying solvent and wall shear stress

Effect of poly(vinyl pyrrolidone) concentration and coagulation bath temperature on the morphology, permeability, and thermal stability of asymmetric cellulose acetate membranes

Electrospinning-Based Nanobiosensors

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