How precisely does ultrasonographic evaluation reflect the histological status of the articular cartilage of the knee joint?

Maeguchi, Kosuke; Ito, Hiromu; Morita, Yoshifumi; Furu, Moritoshi; Fujii, Takayuki; Azukizawa, Masayuki; Okahata, Akinori; Nishitani, Kohei; Kuriyama, Shinichi; Nakamura, Shinichiro; Matsuda, Shinya

doi:10.1016/j.jor.2018.05.046

Cited by 14 publications

(14 citation statements)

References 23 publications

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“…Supporting this, Schmitz et al found that US thicknesses were positively correlated with MRI, but poor absolute agreement existed between the measurements obtained from these two imaging modalities, with US thicknesses 1.9 to 2.8 mm smaller than those on MRI [ 19 ]. On the microscopic level, the US assessment of cartilage morphology seems to correlate with the histological grade [ 20 , 21 ]. Interestingly, for the thicker cartilages, the measured thickness was significantly thinner on US than on histology.…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, for the thicker cartilages, the measured thickness was significantly thinner on US than on histology. Maeguchi et al concluded that US grading and thickness measurements are sufficiently reliable to reflect the histological status [ 21 ]. Ultimately, we are proposing that US measures may be a relative indicator of cartilage thickness but should not be used as an absolute measure.…”

Section: Discussionmentioning

confidence: 99%

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Ultrasonographic Assessment of the Normal Femoral Articular Cartilage of the Knee Joint: Comparison with 3D MRI

Kauppinen

Casula

Zbýň

et al. 2021

The Scientific World Journal

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Objective. Ultrasonography (US) has a promising role in evaluating the knee joint, but capability to visualize the femoral articular cartilage needs systematic evaluation. We measured the extent of this acoustic window by comparing standardized US images with the corresponding MRI views of the femoral cartilage. Design. Ten healthy volunteers without knee pathology underwent systematic US and MRI evaluation of both knees. The femoral cartilage was assessed on the oblique transverse axial plane with US and with 3D MRI. The acoustic window on US was compared to the corresponding views of the femoral sulcus and both condyles on MRI. The mean imaging coverage of the femoral cartilage and the cartilage thickness measurements on US and MRI were compared. Results. Mean imaging coverage of the cartilage of the medial femoral condyle was 66% (range 54%–80%) and on the lateral femoral condyle 37% (range 25%–51%) compared with MRI. Mean cartilage thickness measurement in the femoral sulcus was 3.17 mm with US and 3.61 mm with MRI (14.0% difference). The corresponding measurements in the medial femoral condyle were 1.95 mm with US and 2.35 mm with MRI (21.0% difference), and in the lateral femoral condyle, they were 2.17 mm and 2.73 mm (25.6% difference), respectively. Conclusion. Two-thirds of the articular cartilage of the medial femoral condyle, and one-third in the lateral femoral condyle, can be assessed with US. The cartilage thickness measurements seem to be underestimated by US. These results show promise for the evaluation of the weight-bearing cartilage of the medial femoral condyle with US.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Ultrasonographic Assessment of the Normal Femoral Articular Cartilage of the Knee Joint: Comparison with 3D MRI

Kauppinen

Casula

Zbýň

et al. 2021

The Scientific World Journal

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“…US has limitations such as the lack of a standardised measuring method and validated scoring system, operator‐dependent imaging and reliability and establishment of adequate acquisition parameters. On the other hand, US has major advantages over the other modalities which is highly accurate, reliable, reproducible, fast, economic and patient‐friendly method 34‐36 . Also US has lower demands for processing, lack of radiological exposure, and provides valuable practical information about the current status of the knee joint 34 …”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, US has major advantages over the other modalities which is highly accurate, reliable, reproducible, fast, economic and patient‐friendly method 34‐36 . Also US has lower demands for processing, lack of radiological exposure, and provides valuable practical information about the current status of the knee joint 34 …”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, US has major advantages over the other modalities which is highly accurate, reliable, reproducible, fast, economic and patient-friendly method. [34][35][36] Also US has lower demands for processing, lack of radiological exposure, and provides valuable practical information about the current status of the knee joint. 34 This study might be determined as an initial exploration of the relationship between HP infection and femoral cartilage thickness and one must be careful about interpreting the findings because of the confounding factors and limitations.…”

Section: Discussionmentioning

confidence: 99%

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Ultrasonographic assessment of femoral cartilage thickness in patients with Helicobacter pylori infection

Düzenli

Ata²,

Kosem

et al. 2021

Int J Clin Pract

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Osteoarthritis (OA) is described by the loss and degradation of articular cartilage. 1 Cartilage degeneration is a phenomenon that accelerates over time, as the prevalence of osteoarthritis increases with age. Regardless, old age is not an absolute risk factor as the severity of osteoarthritis in older patients is very variable. Articular cartilage is formed from water, collagen, proteoglycans, electrolytes and chondrocytes, and alterations in cartilage composition may initiate the degenerative process. 2Helicobacter pylori (HP) prevalence is 10%-50% in developed countries and 80% in developing countries, the annual incidence being 1% and 5%-10%, respectively. The epidemiology of HP varies widely according to age, socioeconomic status and geographic area. 3 HP often settles in the upper areas of the gastrointestinal tract, resulting in chronic gastritis. Moreover, HP is a bacterium that can potentially trigger inflammatory disease. [4][5][6] In recent years, OA has been proposed as an inflammatory disease with inflammatory mediators released by cartilage, bone and synovium. 7 Therefore, we hypothesise that HP infections may increase the risk of cartilage degeneration. The effect of HP on distal femoral cartilage has yet to be evaluated. This study aimed to investigate whether there were any differences between the femoral cartilage thickness of HP-positive patients and an HP-negative control group. An ultrasound, which is a

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Increased femoral cartilage thickness in acne patients using isotretinoin: could it be a sign of early osteoarthritis?

Kulaklı,

Elmas Telli,

Sarı

et al. 2024

Arch Dermatol Res

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Vitamin A derivatives have inhibitory effects on cartilage tissue, such as decreasing chondrocyte proliferation and collagen synthesis, and increasing the loss of glycosaminoglycans and proteoglycans. Therefore, isotretinoin (a vitamin A derivative) may play a role in the pathogenesis of cartilage-related diseases like osteoarthritis by affecting the balance of cartilage tissue. The aim of this study was to evaluate the distal femoral cartilage thickness in acne patients under the systemic isotretinoin therapy and to determine whether it constitutes a risk factor for the development of osteoarthritis. The study included 52 patients (42 female, 10 male, mean age 23.31 ± 3.89 years) who were prescribed systemic isotretinoin for acne and completed at least 3 months of treatment, along with 45 healthy controls ((35 female, 10 male, mean age 23.85 ± 4.77 years). Bilateral distal femoral cartilage thickness was measured by ultrasonography before isotretinoin treatment and after the completion of the third month of treatment. After treatment, a statistically significant increase was found in the thickness of the right medial, right lateral, left medial, left lateral, and left intercondylar cartilage (p = 0.014, 0.012, 0.019, 0.027, 0.002, respectively). There was also an increase in the right intercondylar cartilage thickness, but this was not statistically significant (p = 0.1). Systemic isotretinoin seems to make cartilage thicker. The increase in femoral cartilage thickness observed after short-term isotretinoin treatment might be an indicator of very early-stage osteoarthritis. Extended follow-up studies with larger participant pools are necessary to substantiate this result.

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How precisely does ultrasonographic evaluation reflect the histological status of the articular cartilage of the knee joint?

Cited by 14 publications

References 23 publications

Ultrasonographic Assessment of the Normal Femoral Articular Cartilage of the Knee Joint: Comparison with 3D MRI

Ultrasonographic Assessment of the Normal Femoral Articular Cartilage of the Knee Joint: Comparison with 3D MRI

Ultrasonographic assessment of femoral cartilage thickness in patients with Helicobacter pylori infection

Increased femoral cartilage thickness in acne patients using isotretinoin: could it be a sign of early osteoarthritis?

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