How Psychotropic Polypharmacy in Schizophrenia Begins: A Longitudinal Perspective

Shinfuku, Masaki; Uchida, Hiroyuki; Tsutsumi, C.; Suzuki, Takefumi; Watanabe, Koichiro; Kimura, Yasutoshi; Tsutsumi, Yasuhiro; Ishii, Koichi; Imasaka, Yasushi; Mimura, Masaru; Kapur, Shitij

doi:10.1055/s-0031-1297934

Cited by 13 publications

(8 citation statements)

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“…= 1; all P < 0.001). In Japan, the use of high doses of antipsychotics and polypharmacy has been conventionally prevalent . To reduce the high rate of polypharmacy, psychotropic dose equivalence has been suggested for dose standardization; in addition, the public insurance reimbursement system, drug reduction program, and pharmacist intervention policies have been revised to improve and prevent psychotropic polypharmacy .…”

Section: Discussionmentioning

confidence: 99%

Polypharmacy and psychotropic drug loading in patients with schizophrenia in Asian countries: Fourth survey of Research on Asian Prescription Patterns on antipsychotics

Yang

Chen

Najoan³

et al. 2018

Psychiatry Clin Neurosci

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Section: Discussionmentioning

confidence: 99%

Polypharmacy and psychotropic drug loading in patients with schizophrenia in Asian countries: Fourth survey of Research on Asian Prescription Patterns on antipsychotics

Yang

Chen

Najoan³

et al. 2018

Psychiatry Clin Neurosci

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“…Although EPS are known to be caused by dopaminergic blockade8) and the risk of such symptoms increases as the chlorpromazine equivalent value rises,9,10) some other symptoms are caused by different mechanisms7) In addition, antipsychotic drugs are often combined with benzo-diazepine or antiparkinson agents 11). Accordingly, the assessment of side effects during antipsychotic treatment has become increasingly complex.…”

Section: Introductionmentioning

confidence: 99%

Assessment of the Latent Adverse Events of Antipsychotic Treatment Using a Subjective Questionnaire in Japanese Patients with Schizophrenia

Hatano

Kamei

Kato

et al. 2017

Clin Psychopharmacol Neurosci

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ObjectiveThe adverse effects of antipsychotic agents can have a marked influence on medication adherence. In this study, we investigated the adverse events of antipsychotics that are less likely to be reported by patients and the reasons why such symptoms remain latent.MethodsData were collected by interviewing patients using a subjective questionnaire, and the associations between unreported symptoms and background factors were investigated.ResultsA total of 306 patients with schizophrenia or schizoaffective disorder were examined. Their major symptoms were daytime sleepiness (50.0%), weight gain (42.2%), and sexual dysfunction (38.9%). Sexual dysfunction was nominal significantly more common among the patients that had been treated with antipsychotic agent polypharmacy (odds ratio [OR], 2.14; 95% confidence interval [CI], 1.07 to 4.30), and was nominal significantly more common among outpatients (OR, 1.78; 95% CI, 1.02 to 3.13). Only approximately 30% of the patients had reported their symptoms to their physicians.ConclusionPatients receiving antipsychotic treatment tolerate some symptoms and do not feel able to report them to their physicians. The most common reason for this is an insufficient patient-physician relationship. Sexual dysfunction is especially hard to identify because it is a delicate problem, and our findings demonstrate that subjective questionnaires are helpful for detecting such symptoms.

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“…Psychotropic polypharmacy is common in routine psychiatric care (19,20) and in the general population as well (21,22). Delineating the trend of psychotropic polypharmacy may aid in the evaluation of the risks of adverse effects and drug-drug interactions.…”

mentioning

confidence: 99%

Trends in Anxiolytic-Hypnotic Use and Polypharmacy in Taiwan, 2002–2009: A Nationwide, Population-Based Survey

Wang¹,

Chen²,

Chen³

et al. 2014

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How Psychotropic Polypharmacy in Schizophrenia Begins: A Longitudinal Perspective

Abstract: Routine practice deviates significantly from algorithms--with polypharmacy often being initiated early, often a without trial of other options, and once started commonly stays.

Cited by 13 publications

References 13 publications

Polypharmacy and psychotropic drug loading in patients with schizophrenia in Asian countries: Fourth survey of Research on Asian Prescription Patterns on antipsychotics

Polypharmacy and psychotropic drug loading in patients with schizophrenia in Asian countries: Fourth survey of Research on Asian Prescription Patterns on antipsychotics

Assessment of the Latent Adverse Events of Antipsychotic Treatment Using a Subjective Questionnaire in Japanese Patients with Schizophrenia

Trends in Anxiolytic-Hypnotic Use and Polypharmacy in Taiwan, 2002–2009: A Nationwide, Population-Based Survey

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