How Safe is 1% Alum Irrigation in Controlling Intractable Vesical Hemorrhage?

Goswami, AK; Mahajan, Rajesh; Nath, Ranjit Kumar; Sharma, Surinder K.

doi:10.1016/s0022-5347(17)36051-2

Cited by 42 publications

(40 citation statements)

References 8 publications

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“…11 Local adverse effects include suprapubic pain and vesical tenesmus, which can be controlled with antispasmodic and/or analgesic drugs. 12 Encephalopathy has been reported in patients with renal failure, indicating that adequate renal function is essential for clearing a parenteral aluminum load. 13 Complete response rates range from 50% to 100% (Table 2).…”

Section: Aluminummentioning

confidence: 99%

Management of radiation cystitis

2010

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Acute radiation cystitis occurs during or soon after radiation treatment. It is usually self-limiting, and is generally managed conservatively. Late radiation cystitis, on the other hand, can develop from 6 months to 20 years after radiation therapy. The main presenting symptom is hematuria, which may vary from mild to severe, life-threatening hemorrhage. Initial management includes intravenous fluid replacement, blood transfusion if indicated and transurethral catheterization with bladder washout and irrigation. Oral or parenteral agents that can be used to control hematuria include conjugated estrogens, pentosan polysulfate or WF10. Cystoscopy with laser fulguration or electrocoagulation of bleeding points is sometimes effective. Injection of botulinum toxin A in the bladder wall may relieve irritative bladder symptoms. Intravesical instillation of aluminum, placental extract, prostaglandins or formalin can also be effective. More-aggressive treatment options include selective embolization or ligation of the internal iliac arteries. Surgical options include urinary diversion by percutaneous nephrostomy or intestinal conduit, with or without cystectomy. Hyperbaric oxygen therapy (HBOT) involves the administration of 100% oxygen at higher than atmospheric pressure. The reported success rate of HBOT for radiation cystitis varies from 60% to 92%. An important multicenter, doubleblind, randomized, sham-controlled trial to evaluate the effectiveness of HBOT for refractory radiation cystitis is currently being conducted.

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Section: Aluminummentioning

confidence: 99%

Management of radiation cystitis

2010

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“…Nephrotoxic, systemic toxicity D 1 (Praveen et al, 1992) 3 (Goswami et al, 1993;Efros et al, 1994) Formalin instillation…”

Section: Cessation Of Bleeding Probably Effectivementioning

confidence: 99%

“…These events mostly occurred in the context of renal impairment, making alum salts a drug to be used with caution. Prothrombin time and Aluminium levels are useful for monitoring toxicity (Goswami et al, 1993). We identified only one retrospective case series in patients with HC following HSCT (Efros et al, 1994).…”

Section: Guideline ª 2008 the Authorsmentioning

confidence: 99%

Prevention and management of BK‐virus associated haemorrhagic cystitis in children following haematopoietic stem cell transplantation – a systematic review and evidence‐based guidance for clinical management

et al. 2008

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SummaryHaemorrhagic cystitis (HC) is a common and, in its severe form, potentially life-threatening complication of Haematopoietic stem cell transplantation (HSCT) in children. Recent data indicate an important role of BK virus reactivation during the time of maximal post-transplant immune suppression in the pathogenesis of late-onset HC. Treatment of HC is mainly symptomatic and often frustrating. To give clinicians guidance on prevention and treatment options and their backing by scientific evidence, we have systematically assessed the available literature and devised evidence-based guidelines. Our comprehensive review demonstrates that evidence for the most commonly used interventions (such as cidofovir, oestrogen, hyperbaric oxygen, bladder instillation with formalin, alum salts or prostaglandin) is very limited. Some of these interventions also carry significant risks. Higher level evidence exists only for 2-mercaptoethane sodium (MESNA) and hyperhydration as a preventative intervention, and for systemic recombinant Factor VII as a treatment to stop acute haemorrhage. Further high-quality studies are required to establish effective and safe prevention and treatment options for HC.

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“…Moreover, alum has been recommended as category I active ingredient in mouthwashes by the Counter Advisory Panel of US Food and Drug Administration (Olmez et al, 1998). It is used as an astringent and successful in controlling profuse bleeding by ensuring effective blood clotting (Goswami et al, 1993). Aluminum Potassium Sulfate is entitled in Arabic, Greek and Indian as "Sheb, Kholel-ol-gheys, Paahtekri", respectively.…”

Section: Introductionmentioning

confidence: 99%

In Vitro Study of Concentration-Effect and Time-Course Pattern of White Alum on Escherichia Coli O157:h7 Growth

Shahriari¹,

Salari²,

Shahriari³

2017

Afr J Tradit Complement Altern Med

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Background: Nowadays, the demand for antibacterial fabrics has increased. White alum is used for oral aphthous ulcers treatment in traditional medicine of Sistan city, Sistan and Baluchistan Province, Iran, and also as a flocculent for water purification. This study is aimed to evaluate the effect of concentration and time on antibacterial activity of white alum on Escherichia coli O157:H7. Materials and Methods: 0.25, 0.5, 1 and 2% concentrations of white alum were added to 10 8 CFU of Escherichia coli O157:H7. Optical Density was recorded for 4 hours. Data obtained were analyzed using Repeated Measure and Oneway ANOVA by SPSS. Results: Results revealed the effectiveness of white alum in the growth of the tested bacterium. The white alum was found to be potent against Escherichia coli O157:H7 at a concentration above 1% (p<0.05). Also, its effect is dose and time dependent, as well as other disinfectants. Conclusion: A wide variety of natural products has been under scrutiny for their clinical potential, both in terms of prevention and treatment. Strong antibacterial activity of white alum compared with control was shown against tested bacterium. In conclusion, white alum can be used as an inhibitor of bacterial growth, especially for Escherichia coli O157:H7.

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How Safe is 1% Alum Irrigation in Controlling Intractable Vesical Hemorrhage?

Cited by 42 publications

References 8 publications

Management of radiation cystitis

Management of radiation cystitis

Prevention and management of BK‐virus associated haemorrhagic cystitis in children following haematopoietic stem cell transplantation – a systematic review and evidence‐based guidance for clinical management

In Vitro Study of Concentration-Effect and Time-Course Pattern of White Alum on Escherichia Coli O157:h7 Growth

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