How the theory of centralized aerobic-anaerobic energy balance compensation explains sudden cardiac death in young athletes

Vetcher, Alexandre A.; Zhukov, Kirill V.; Gasparyan, Bagrat A.; Shishonin, Alexander Y.

doi:10.1016/j.ejim.2022.10.022

Cited by 2 publications

(2 citation statements)

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Section: Introductionmentioning

confidence: 99%

“…So far, this approach has been successfully employed in the explanation of AHT [14], DM [11], left ventricular hypertrophy [25], sudden cardiac death [26], vertebral cartilage issues [27], and problems with posture [28] (Figure 1). Let us underline that the TCAAEBC provides the view on the way of interconnection of multiple NCOs through the acknowledgement of the main role of the central nervous system (CNS).…”

Section: Introductionmentioning

confidence: 99%

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Different Trajectories for Diabetes Mellitus Onset and Recovery According to the Centralized Aerobic–Anaerobic Energy Balance Compensation Theory

Vetcher,

Zhukov,

Gasparyan

et al. 2023

Biomedicines

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We recently reported that the restoration of cervical vertebral arterial blood flow access (measured as systolic peak (PS)) to the rhomboid fossa leads to the recovery of the HbA1c level in the case of patients with a pre-Diabetes Mellitus (pre-DM) condition. The theory of centralized aerobic–anaerobic energy balance compensation (TCAAEBC) provides a successful theoretical explanation for this observation. It considers the human body as a dissipative structure. Reported connections between arterial hypertension (AHT) and the level of HbA1c are linked through OABFRH. According to the TCAAEBC, this delivers incorrect information about blood oxygen availability to the cerebellum. The restoration of PS normalizes AHT in 5–6 weeks and HbA1c in 12–13 weeks. In the current study, we demonstrate the model which fits the obtained experimental data. According to the model, pathways of onset and recovery from pre-DM are different. The consequence of these differences is discussed. The great significance of the TCAAEBC for medical practice forces the creation of an appropriate mathematical model, but the required adjustment of the model needs experimental data which can only be obtained from an animal model(s). The essential part of this study is devoted to the analysis of the advantages and disadvantages of widely available common mammalian models for TCAAEBC cases.

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