This study looked at how financial inclusion and literacy, as a mediation variable, affected the relationship between education, employment, and e-commerce and poverty in Indonesia. Reflective indicators and factor schemes were used in the analysis, which employed the Partial Least Square (PLS) method of structural equation modeling (SEM). Four significant indicators relate to education, two to employment, two to e-commerce, six to poverty, and two to financial inclusion and literacy. The findings indicated that employment and education had a significant negative impact on poverty. On the other hand, e-commerce, financial literacy, and inclusion factors have a positive and significant effects on poverty. Financial literacy and inclusion are not considerably influenced by education, but employment has a significant negative impact on these factors. E-commerce also has a negative impact on these factors.