How to compare cardiovascular disease and risk factors in elderly patients with haemophilia with the general population

Berger, Karin; Schopohl, Dorothee; Lowe, G. D. O.; Holme, Pål André; Tait, R. C.; Combescure, Christophe; Rauchensteiner, Stephan; Klamroth, Robert

doi:10.1111/hae.13069

Cited by 12 publications

(15 citation statements)

References 40 publications

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“…The European H3 study collected data on CVD morbidity and risk factors in 532 PWH aged ≥ 40 years and showed that CVD and risk factors are present in PWH and that hypertension is prevalent in people with severe haemophilia at least to the same degree as in non‐severe haemophilia 15 . When these data were compared with the German general population data, PHW were found to have a higher prevalence of hypertension but a significant lower rate of CAD 16 . In a US study, the prevalence of CVD was found to be 15% among 200 patients with moderate or severe haemophilia and 25.8% among age‐ and sex‐matched patients from the general population 17 .…”

Section: Cardiovascular Diseasementioning

confidence: 99%

Management of comorbidities in haemophilia

2020

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With the introduction of clotting factor concentrates in the early 1970s, significant improvements in quality of life and life expectancy of persons with haemophilia (PWH) were realized. Unfortunately, as a result of transmission of HIV and hepatitis C virus (HCV) by contaminated concentrates in the 1980s, many of these gains were lost. Now with four decades of PWH unexposed to contaminated factor products and current treatments capable of suppressing and eliminating HIV and HCV, respectively, the survival rate is once again increasing. In addition to the usual comorbidities associated with advanced age in the general population, several specific issues occur in patients with bleeding disorders. This manuscript explores the incidence and management of the comorbidities of the ageing PWH with a focus on cardiovascular disease and osteoporosis.

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Section: Cardiovascular Diseasementioning

confidence: 99%

Management of comorbidities in haemophilia

2020

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“…A study evaluating the cause of mortality of 6,018 hemophilia patients in the United Kingdom found that mortality from CAD was lower at only 62% of the general population rates (9). Berger et al compared the data on ASCVD and risk factors in PWH aged >40 years with published German general population data and found PWH to have a higher prevalence of hypertension but a lower rate of CAD (10).…”

Section: Cad and Ascvd Risk In Pwhmentioning

confidence: 99%

Current concepts in the management of stable ischemic heart disease and acute coronary syndrome in patients with hemophilia

Jabbar¹,

Baydoun²,

Janbain³

et al. 2018

Ann. Transl. Med.

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Coronary artery disease (CAD), including stable ischemic heart disease (SIHD) and acute coronary syndrome (ACS), remains the leading cause of death in the US and one of the primary modalities used in the treatment of CAD is percutaneous coronary intervention (PCI). Despite the potential benefits of PCI in high risk CAD patients, the risk of hemorrhage presents a dilemma in the treatment of patients with hemophilia A and B. In an attempt to provide guidance on the management of SIHD and ACS in patients with hemophilia, we present the case of a patient with moderate hemophilia B and ACS who subsequently underwent PCI followed by a review of the associated literature.

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“…There are several potential reasons that may explain the low incidence of coronary artery disease in patients with haemophilia. They have hipocoagulable status and are significantly less likely to form a thrombotic mass, and they also have less established atheroma in blood vessels [12]. However, patients with haemophilia might not be protected against atherosclerosis, as demonstrated by clinical studies [13] and autopsy reports on haemophiliacs with fatal myocardial infarction showing extensive atherosclerotic lesions, but only rarely fresh thrombi [14].…”

Section: Discussionmentioning

confidence: 99%

The first case of surgical myocardial revascularization and endarterectomy of the right carotid artery in the same procedure in a patient with haemophilia A

Simić

Mikić

et al. 2021

VOJNOSANIT PREGL

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by the Editorial Board of the Vojnosanitetski Pregled. They have not yet been copy edited and/or formatted in the publication house style, and the text could still be changed before final publication. Although accepted manuscripts do not yet have all bibliographic details available, they can already be cited using the year of online publication and the DOI, as follows: article title, the author(s), publication (year), the DOI.

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How to compare cardiovascular disease and risk factors in elderly patients with haemophilia with the general population

Abstract: Increased prevalence of hypertension in PWH should trigger regular screening. CHD does occur in PWH aged ≥60 years though apparently with lower prevalence. Given the growing population of elderly PWH, guidelines for prevention and treatment of CVD should be developed.

Cited by 12 publications

References 40 publications

Management of comorbidities in haemophilia

Management of comorbidities in haemophilia

Current concepts in the management of stable ischemic heart disease and acute coronary syndrome in patients with hemophilia

The first case of surgical myocardial revascularization and endarterectomy of the right carotid artery in the same procedure in a patient with haemophilia A

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