“…Several papers describe the changes in AGEs and other biomarkers in cardiovascular disease, including discussion of the usefulness of skin autofluorescence as a proxy for chemical or immunological measurement of tissue AGE accumulation in cardiovascular disease [17], and changes in AGEs and other biomarkers associated with hypertension [18] and metabolic syndrome [19]. Four more speculative papers present directions for future research, including basic research on the role of the Maillard reaction in endoplasmic reticulum stress [20], and the interaction between Maillard reactions and nitrosative stress [21], and applied research on the development of a reconstructed skin model for research on skin glycation [22] and approaches for limiting AGE damage to skin [23].…”