How to Increase the Effectiveness of Antihypertensive Therapy in Clinical Practice: Results of the Russian Observational Program FORSAZH

Antihypertensive Effectiveness of Perindopril Arginine and Indapamide Single-Pill Combination According to Body Mass Index: Findings from the FORSAGE Study

“…Patients in groups 2 and 3 also received counseling for non-pharmacological treatments for hypertension, including dietary and salt intake recommendations. The methods and main findings of the study have been previously published in Russian [8]. A total of 442 general practitioners (GPs) and internists participated in the program and enrolled 1969 patients with essential arterial hypertension having BP [ 150/ 90 mmHg despite treatment.…”

“…The data obtained from FORSAGE indicated that switching to full-dose perindopril arginine/ indapamide SPC resulted in three quarters of the study population achieving target BP values [8]. Moreover, the increase in treatment effectiveness was similar between the group of patients whose physicians received additional education within the program and those who did not [8].…”

“…In 2015, we conducted the open-label, observational FORSAGE study in which patients were switched from previous antihypertensive therapy to full-dose perindopril arginine/indapamide SPC and physicians educated on how to encourage patients to lead a healthy lifestyle with the aim of improving achievement of target BP and increasing adherence to treatment [8]. The data obtained from FORSAGE indicated that switching to full-dose perindopril arginine/ indapamide SPC resulted in three quarters of the study population achieving target BP values [8]. Moreover, the increase in treatment effectiveness was similar between the group of patients whose physicians received additional education within the program and those who did not [8].…”

“…Nevertheless, almost a quarter of patients did not achieve the target BP level. The main factors underlying this failure were male gender, age over 60 years, poor treatment adherence at baseline, persistent high cholesterol levels, higher baseline BP levels, low glomerular filtration rate (GFR), high heart rate, and increased body mass index (BMI) [8]. The aim of the current post hoc analysis of the FORSAGE study was to assess the effectiveness of the perindopril arginine/indapamide (10 mg/2.5 mg) SPC in patients with arterial hypertension with regard to baseline BMI.…”

Influence of altiazem pp-180 on hemodynamic parameters in arterial hypertension patients under outpatient conditions

“…Unlike verapamil, it does not cause acute cardio depression and does not lead to a sudden excessive activation of the sympathetic nervous system resulting in tachycardia, as dihydropyridine drugs do. Besides, there are a lot of AH patients with co-morbidity who are not recommended to take drugs of a different class; in particular, these are tachycardia-prone patients, patients with pulmonary pathology, peripheral vasospasm-prone patients; in this instance, it would be preferable to use diltiazem 18,15,8,17 . The study of both hypotensive and other effects of diltiazem would create an opportunity to comprehensively evaluate its efficacy in terms of arterial pressure control, its effect on endothelial dysfunction, and an opportunity to prevent cardiovascular complications.…”