How to Interpret and Pursue an Abnormal Complete Blood Cell Count in Adults

Tefferi, Ayalew; Hanson, Curtis A.; Inwards, David J.

doi:10.4065/80.7.923

Cited by 197 publications

(146 citation statements)

References 108 publications

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“…Sometimes, it could indicate an underlying problem and that is the reason high WBC would always require further medical evaluation as it could indicate infection, trauma, inflammation, tissue damage, allergy amongst others. It has also been associated with the use of certain medications like corticosteroids, antibiotics, antiepileptic drugs, (Tefferi et al, 2005). The observed increase in WBC in this study could be attributed to any of the aforementioned.…”

Section: Discussionmentioning

confidence: 48%

Toxicity Evaluation of Yoyo 'Cleanser' Bitters and Fields Swedish Bitters Herbal Preparations following Sub-Chronic Administration in Rats

Ekor¹

2010

American Journal of Pharmacology and Toxicology

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Problem statement:Owing to numerous adverse effects of most orthodox pharmaceuticals, the use of herbal remedies in treatment and prevention of diseases is gaining much attention, especially in developing countries. The increase patronage of these remedies is often predicated on the assumption that they are harmless since they are prepared from natural sources. However, toxicity related to herbal medicines is becoming widely recognized. Yoyo 'Cleanser' Bitters (YB) and Fields Swedish Bitters (SB) are herbal preparations largely consumed in Nigeria because of their high publicity in the various national news media. This study evaluated their toxicity potentials following sub-chronic administration in rats. Approach: Thirty-five Wistar rats were divided into five groups of 7 rats/group. Control received normal saline while the experimental groups were treated separately with 15 and 30 mL kg −1 of YB and SB respectively. Treatment was given daily by gavage for 30 days. Body weights were measured weekly and rats were sacrificed 24 h after last treatment. Blood was collected by cardiac puncture for biochemical and haematological assessment. Vital organs were also excised and weighed. Results: YB and SB did not significantly affect creatinine, blood urea nitrogen, Na + ion but significantly (p<0.01) decreased K + ion concentration when compared with control. Both herbal preparations produced moderate increases in alanine and aspartate aminotransferase activities, with YB (30 mL kg −1 ) significantly (p<0.05) increasing the latter. YB and SB did not significantly alter total cholesterol, triglycerides and albumin but SB (30 mL kg −1 ) significantly (p<0.05) decreased total protein when compared with control. SB significantly (p<0.05) elevated white blood cell count while other haematological parameters, vital organs and body weights were not significantly affected by both herbal preparations. Conclusion: YB and SB possess the risk of inducing hypokalaemia. The potential to also increase markers of liver function calls for cautious use in conditions associated with liver impairment.

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Section: Discussionmentioning

confidence: 48%

Toxicity Evaluation of Yoyo 'Cleanser' Bitters and Fields Swedish Bitters Herbal Preparations following Sub-Chronic Administration in Rats

Ekor¹

2010

American Journal of Pharmacology and Toxicology

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“…17 NLR is a practical, cost-effective and valuable marker of inflammatory state that can easily be calculated from CBC tests. 18 It has been found to be a valuable predictor of poor prognosis and long-term mortality in oncological patients, in coronary artery disease, end-stage renal disease and inflammatory diseases such as ulcerative collitis and appendicitis. [19][20][21][22][23][24] When WBC parameter was examined in the current study, there were no significant differences between the patients and the controls in any of the three groups.…”

Section: Discussionmentioning

confidence: 99%

Study the relationship between nasal polyps, platelet count, mean platelet volume, neutrophil/lymphocyte ratio in patients attending otolaryngology OPD in a tertiary care teaching hospital, West Bengal

Sharma

Raman²,

Ray

et al. 2017

Int J Otorhinolaryngol Head Neck Surg

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Original Research ArticleStudy the relationship between nasal polyps, platelet count, mean platelet volume, neutrophil/lymphocyte ratio in patients attending otolaryngology OPD in a tertiary care teaching hospital, West Bengal ABSTRACTBackground: Nasal obstruction is a common cause of marked nasal septal deviation. It is related strongly with hypoxia. Hypoxic conditions increase mean platelet volume levels. Many studies in literature point out that inflammation related to nasal polyp is mostly dependent on eosinophils and their inflammatory products. Beside eosinophils, platelets may have a role in nasal polyp development. Platelets are involved in hemostasis, tissue repairing and inflammation. Recently, mean platelet volume (MPV) was recognized as a simple inflammatory marker in the inflammatory disease. This study investigated the relationship of nasal polyps with MPV (mean platelet volume), platelet count and NLR (neutrophil to lymphocyte ratio). Methods:The cross-sectional observational study we investigated CBC (complete blood count) parameters of the patients that consulted ENT clinic in a tertiary care teaching hospital, Haldia because of nasal polyp. About 76 patients and 42 controls were included in this study. In all groups, WBC (white blood cell count), RBC (red blood cell count), RDW (red cell distribution width), platelet count, MPV, PDW (platelet distribution width) and NLR parameters from CBC (complete blood count) were compared between patients and controls. Results:Mean WBC values were 6.89±1.33×103/μL in patients with NPs, vs. 7.11±2.32×103/μL in the control group. Mean haemoglobin (Hb) values were 13.19±1.34 g/dL in patients with NPs, vs. 14.1±1.67 g/dl in the control group. Mean MPV values were 9.11 ± 1.08 fL in patients with NPs, vs. 8.32±0.53 fL in the control group. Mean PLT values were 232.38 ± 39.97×103/μL in patients with NPs, vs. 271.44±45.14×103 in the control group. MPV was higher in nasal polyp patients, whereas platelet count was higher in controls. The difference was significant for the mean absolute neutrophil, platelet count, and lymphocyte counts, NLR, PDW and MPV values between the study group and the control group. Conclusions: Platelet count and NLR were significantly lower in patients than the controls, whereas MPV was significantly higher in nasal polyp patients.

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“…chronic myeloid leukaemia; suspected organ failure such as renal disease, liver failure; features of hyperviscosity syndrome as in paraproteinaemias, leukaemic hyperleucocytosis, polycythaemia; severe bacterial sepsis and parasitic infections; malignancies with possible bone marrow involvement; suspected cases of nutritional anaemia; suspected chronic lymphoproliferative diseases such as chronic lymphocytic leukaemia; lymphoma with leukaemic spills; evaluation of therapeutic response in haemopathies among others. [2,4,5] …”

Section: Indications For a Peripheral Blood Filmmentioning

confidence: 99%

Peripheral blood smears - An innovative Review

Prasad¹

2017

Int. J. Curr. Res. Med. Sci.

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The peripheral blood film (PBF) is a laboratory work-up that involves cytology and somehow cell morphology of blood cells. As basic as it is, PBF is invaluable and of great use in the characterization of various clinical diseases. This article highlights the basic science and art of importance behind the PBF. It expounds its laboratory applications, clinical indications and interpretations in the light of various clinical and sub clinical diseases. Despite advances in hematology automation and application of molecular techniques, the PBF has remained a very important diagnostic tool to the hematologist and clinician. A good quality blood smear, thorough examination and proper interpretation prognosed and diagnosed with patient's clinical state should be ensured by the clinical-pathologist. Clinicians should be abreast with its clinical utility and proper application of the reports in the management of patient's state and care.

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How to Interpret and Pursue an Abnormal Complete Blood Cell Count in Adults

Cited by 197 publications

References 108 publications

Toxicity Evaluation of Yoyo 'Cleanser' Bitters and Fields Swedish Bitters Herbal Preparations following Sub-Chronic Administration in Rats

Toxicity Evaluation of Yoyo 'Cleanser' Bitters and Fields Swedish Bitters Herbal Preparations following Sub-Chronic Administration in Rats

Study the relationship between nasal polyps, platelet count, mean platelet volume, neutrophil/lymphocyte ratio in patients attending otolaryngology OPD in a tertiary care teaching hospital, West Bengal

Peripheral blood smears - An innovative Review

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