How to prevent and manage Tumor lysis syndrome

Effective Prevention and Management of Tumor Lysis Syndrome in Children With Cancer

“…Stop the infusion of rasburicase when the first sign of hypersensitivity reaction occurs. It is also essential for pediatric oncology nurses to obtain the vital signs, and to assess and maintain the patient’s airway, breathing, and circulation (Held-Warmkessel, 2010).…”

“…Pediatric oncology nurses must first assess the pediatric oncology patients’ and families’ levels of understanding before beginning the education process. Pediatric oncology patients, and especially their family members, should understand what TLS is, what its symptoms are, and the prophylactic measures and treatment interventions it requires (Held-Warmkessel, 2010). Because of the complexity of the clinical syndrome and its treatment, continuous instruction from pediatric oncology nurses may be required to enhance the family members’ understanding and to allay their anxieties.…”

“…As reduction of plasma uric acid levels may take several days, the preexisting uric acid must be excreted first. Additionally, allopurinol may interfere with the excretion of other drugs used in the treatment of leukemia, such as azathioprine, cyclophosphamide, and 6-mercaptopurine (Coiffier et al, 2008; Held-Warmkessel, 2010).…”

Management of Tumor Lysis Syndrome in Patients With Multiple Myeloma During Bortezomib Treatment

“…Oncology nurses should be familiar with the signs and symptoms of hyperuricemia, hyperphosphatemia, hyperkalemia, and hypocalcemia. Nurses should attach importance to any abnormal laboratory results that may be a risk factor for TLS or a sign of the disorder itself; special attention should be paid to abnormal renal function (Held-Warmkessel, 2010). Monitoring and management becomes much more significant for those patients with MM who have an increased risk of developing TLS (e.g., high tumor burdens, intent to receive the first cycle of bortezomib treatment).…”

Tümör Lizis Sendromunda Hemşirelik Yaklaşımı

“…Parenteral olarak önerilen günlük sıvı miktarı 3.000 ml / m 2 'dir. Hidrasyonun sağlanmasıyla; yüksek idrar çıkışı sağlanarak (100 ml / m2'nin üzerinde her saat), kalsiyum fosfat çökeltisi riski azaltılmaktadır (Held-Warmkessel, 2010;Kaplow ve Iyere, 2016).…”