How to Tackle Tremor – Systematic Review of the Literature and Diagnostic Work-Up

Buijink, A. W. G.; Contarino, Maria Fiorella; Koelman, Johannes H. T. M.; Speelman, Johannes D.; Rootselaar, A.F. van

doi:10.3389/fneur.2012.00146

Cited by 21 publications

(37 citation statements)

References 94 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…All statistical analyses were performed with the IBM SPSS Statistics 19.0 software package assuming a 0.05 level of significance III. RESULTS Both groups of patients displayed a peak of frequency from 4 Hz to 7 Hz for both tasks as reported in the literature ( [6,8,15]). A careful visual observation of the peaks of frequency could not detect any difference between the loaded and the unloaded tasks.…”

Section: Data Processing and Statistical Analysessupporting

confidence: 69%

Tremor modulations across periods with and without voluntary motion and limb load task demands using movement quantification

Pascoal‐Faria¹,

Patrício

Philipiak

et al. 2013

2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

View full text Add to dashboard Cite

Understanding the neurobiological mechanisms underlying different types of tremor and the altered functional connectivity of the involved areas is a timely goal in clinical neuroscience. If successful, this quest may open new perspectives on how to achieve tremor modulation, which is notably relevant, in Parkinson's disease (PD). Tremor can be characterized by simple parameters such as frequency and amplitude. It is therefore prone to be objectively targeted by neuromodulation and quantitatively investigated using multimodal techniques, such as, accelerometry, EMG and functional Magnetic Resonance Imaging (fMRI). Embarking on the latter challenge requires an a priori knowledge of how effective functional connectivity is altered in PD tremor. This works aims to ascertain which postural and voluntary movement tasks with distinct types of physical load are suitable for designing efficient fMRI protocols, by performing an accelerometry analysis to measure spontaneous and imposed tremor modulation on cohorts of PD patients, essential tremor patients and a group of voluntary healthy controls.

show abstract

Section: Data Processing and Statistical Analysessupporting

confidence: 69%

Tremor modulations across periods with and without voluntary motion and limb load task demands using movement quantification

Pascoal‐Faria¹,

Patrício

Philipiak

et al. 2013

2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

View full text Add to dashboard Cite

show abstract

“…Tremor is a common feature of a variety of neurological disorders, including essential tremor (ET), Parkinson’s disease (PD), and dystonia [1]. In genetic studies of ET, investigators must screen potential enrollees (i.e., reportedly affected relatives) by mail or telephone to ensure that they do not have other neurological conditions.…”

Section: Introductionmentioning

confidence: 99%

The spiral axis as a clinical tool to distinguish essential tremor from dystonia cases

Michalec¹,

Hernández²,

Clark³

et al. 2014

Parkinsonism & Related Disorders

View full text Add to dashboard Cite

Background: Tremor is a common feature of a variety of neurological disorders. In genetic studies of essential tremor (ET), investigators need to screen potential enrollees by mail or telephone to exclude those with other neurological conditions, especially dystonia. In clinical settings, the differentiation of ET and dystonia may also be very challenging. We hypothesized that the spiral axis, described below, is a useful screening tool to distinguish ET cases from dystonia cases. Methods: We analyzed the hand-drawn spirals of 135 individuals enrolled in a genetics study at Columbia University Medical Center. Each of the four spirals was assessed for the presence of a single identifiable tremor orientation axis, and a spiral axis score (range = 0 – 4) [a single axis on all 4 spirals] was assigned to each enrollee. Results: There were 120 ET cases and 15 cases with dystonic tremor. Most (101/120, 84.2%) ET cases had an axis score ≥1 vs. only half (8/15, 53.3%) of the dystonia cases (p =0.02). Receiver Operator Curve (ROC) analysis revealed that the use of a spiral axis score ≥2 as a cut off would exclude 60.0% of dystonia cases while including 67.5% of ET cases. Conclusion: Handwritten spirals appear to have a single predominant axis in more ET than dystonia cases. The evaluation of this axis has moderate diagnostic validity as a screening tool to distinguish ET cases from those with dystonia. Although this study did not assess the utility of this tool in clinical practice settings, future studies should do so.

show abstract

“…Bender visual-motor gestalt test (BGT) (Kishi et al 1993), and Benton visual retention test (B-VRT) (Mathiesen et al 1999; Bast-Pettersen et al 2005). The results of static steadiness, aiming, and tracking/drawing tests have been used to classify tremor respectively as postural, intention, or kinetic (Louis et al 2000;Louis 2007; Buijink et al 2012; National Institute of Neurological Disorders and Stroke 2012; Gonzalez-Usigli & Espay 2013; Sternberg et al 2013). …”

Section: Resultsmentioning

confidence: 99%

Persistence of mercury-induced motor and sensory neurotoxicity: systematic review of workers previously exposed to mercury vapor

Fields¹,

Borak

Louis

2017

Critical Reviews in Toxicology

View full text Add to dashboard Cite

Background Elemental mercury (Hg0) is a well-recognized neurotoxicant, but it is uncertain whether and for how long its neurotoxicity persists. Among studies that evaluated previously-exposed workers, only one examined workers during and also years after exposure had ceased. Objective To create a series of ‘synthetic’ longitudinal studies to address the question of persistence of Hg0 neurotoxicity in occupationally exposed workers. Methods We systematically reviewed studies describing objective motor and sensory effects in previously-exposed mercury workers. Data from physical examination (PE), neurobehavioral (NB) tests and electrophysiological studies were extracted into structured tables and examined for their consistency and dose-relatedness and then compared with the corresponding results from studies of currently-exposed workers. Results We identified six cohorts that described neurological findings in 1299 workers, examined an average of 4.8 to 30 years after the cessation of exposure. Historical group mean UHg levels ranged from 23 to >500 μg/L, with UHg levels >6000 μg/L in some individuals. Overall, few findings were significant; most were inconsistent across the remote-exposure studies, and in comparisons between studies of remotely- and currently-exposed workers. Conclusion The results of this systematic review indicate that Hg0-related neurotoxic effects detectable on PE, NB testing, and EPS are substantially reversed over time. To the extent that such effects do persist, they are reported principally in workers who have had very high dose exposures. In addition, based on limited available data, those effects reported to persist have been described as having little or no functional significance.

show abstract

How to Tackle Tremor – Systematic Review of the Literature and Diagnostic Work-Up

Cited by 21 publications

References 94 publications

Tremor modulations across periods with and without voluntary motion and limb load task demands using movement quantification

Tremor modulations across periods with and without voluntary motion and limb load task demands using movement quantification

The spiral axis as a clinical tool to distinguish essential tremor from dystonia cases

Persistence of mercury-induced motor and sensory neurotoxicity: systematic review of workers previously exposed to mercury vapor

Contact Info

Product

Resources

About