How to use antistreptolysin O titre

Sen, Ethan S; Ramanan, Athimalaipet V

doi:10.1136/archdischild-2013-304884

Cited by 21 publications

(16 citation statements)

References 24 publications

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“…The exacerbation of symptoms must be associated with the infection of group A Streptococci, which needs to be confirmed with the positive swab from the throat and/or increased titers of antistreptolysin-O (ASO) or anti-DNase B [56,57]. In the case of PANDAS, GAS infection usually occurs without macroscopic changes in the throat and symptoms of pharyngitis.…”

Section: Association With Infection Of Streptococci Group Amentioning

confidence: 99%

Alterations in the Nervous System and Gut Microbiota after β-Hemolytic Streptococcus Group A Infection—Characteristics and Diagnostic Criteria of PANDAS Recognition

Baj

Sitarz

Forma

et al. 2020

IJMS

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The objective of this paper is to review and summarize conclusions from the available literature regarding Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS). The authors have independently reviewed articles from 1977 onwards, primarily focusing on the etiopathology, symptoms, differentiation between similar psychiatric conditions, immunological reactions, alterations in the nervous system and gut microbiota, genetics, and the available treatment for PANDAS. Recent research indicates that PANDAS patients show noticeable alterations within the structures of the central nervous system, including caudate, putamen, globus pallidus, and striatum, as well as bilateral and lentiform nuclei. Likewise, the presence of autoantibodies that interact with basal ganglia was observed in PANDAS patients. Several studies also suggest a relationship between the presence of obsessive-compulsive disorders like PANDAS and alterations to the gut microbiota. Further, genetic predispositions—including variations in the MBL gene and TNF-α—seem to be relevant regarding PANDAS syndrome. Even though the literature is still scarce, the authors have attempted to provide a thorough insight into the PANDAS syndrome, bearing in mind the diagnostic difficulties of this condition.

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Section: Association With Infection Of Streptococci Group Amentioning

confidence: 99%

Alterations in the Nervous System and Gut Microbiota after β-Hemolytic Streptococcus Group A Infection—Characteristics and Diagnostic Criteria of PANDAS Recognition

Baj

Sitarz

Forma

et al. 2020

IJMS

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“…An increase in ASO titer can be used as an indicator of previous GAS infection. In clinical practice, the timing of a GAS infection is unknown with a single ASO measurement (22). However, as in our study, in patients with progressive findings under standard treatment for soft tissue infections, considering the invasive GAS, clindamycin may be added to the treatment of toxin suppressive effects.…”

Section: Discussionmentioning

confidence: 74%

Clinical Characterics, Laboratory Features, and Management of Odontogenic Facial Cellulitis

Kaman¹,

Teke²,

Öz³

et al. 2018

J Pediatr Inf

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Diş çürükleri, dünya çapında en yaygın kronik hastalıklardandır. Bu çalışmanın amacı diş kaynaklı fasiyal selülit nedeniyle hastaneye yatırılan çocuk hastaların klinik özelliklerinin ve tedavi yöntemlerinin değerlendirilmesidir. Gereç ve Yöntemler: Bu çalışmada, diş kaynaklı fasiyal selülit tanısı ile Ocak 2013-Aralık 2017 tarihleri arasında çocuk enfeksiyon hastalıkları servisinde yatırılarak takip edilen hastaların diş sağlığına ilişkin öyküleri, klinik ve laboratuvar özellikleri ile tedavi şekilleri geriye dönük olarak değerlendirildi. Bulgular: Çalışmaya ortanca yaşları 86 ay (min-maks: 19-207 ay) olan 98 (43 kız, 55 erkek) hasta alındı. Hastaların 45 (%45.9)'inin düzenli diş fırçalama alışkanlığı yoktu. Kırk sekiz (%48.9) hastanın herhangi bir diş tedavisi öyküsü yoktu. On sekiz (%18.3) hasta hiç diş hekimine başvurmamıştı. Hastaların 75 (%76.5)'i ilk kez diş kaynaklı fasiyal selülit tanısı alırken, 4 (%4)'ü daha önce aynı tanıyla hastanede yatırılmıştı. Otuz yedi (%37.8) hastanın başvuruda ateşi vardı. Hastaların başvurudaki ortalama beyaz küre sayısı 11.981 ± 4.233/mm 3 , eritrosit sedimentasyon hızı 29.1 ± 17.6 mm/saat ve C-reaktif protein (CRP) değeri 35.2 ± 39.4 mg/L olarak saptandı. Ortalama intravenöz (IV) antibiyotik tedavi süresi 5.5 ± 2.5 gün, toplam antibiyotik tedavi süresi 12.5 ± 2.9 gündü. Hastaların 82 (%83.7)'sine ampisilin-sulbaktam başlanmıştı. On beş (%15.3) hastanın

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“…Also, ASO titer does not always indicate a recent streptococcal infection. Therefore, an increase in an ASO titer is indicative of a preceding group A Streptococcus infection, so sequential measurements are recommended [17-19]. We attempted to obtain 2 sequential measurements, but only a single sampling was performed in some patients.…”

Section: Discussionmentioning

confidence: 99%

High antistreptolysin O titer is associated with coronary artery lesions in patients with Kawasaki disease

et al. 2019

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Purpose In Kawasaki disease (KD) patients, coronary artery complications, incomplete and refractory types occur more frequently in patients with streptococcal or other bacterial/viral infections. Recently, we observed a higher incidence of coronary lesions in KD patients with high anti-streptolysin O (ASO) titer. Therefore, we hypothesized that KD patients diagnosed with concurrent streptococcal infection have poor prognoses, with respect to treatment response and development of coronary artery lesions. Methods A retrospective review was performed in 723 patients with KD who were admitted to 2 major hospitals between June 2010 and September 2017. Results Among 723 patients with KD, 11 initially showed an elevated ASO titer (>320 IU/mL) or elevated follow-up ASO titer after treatment. Of these patients, 5 showed no response to the first intravenous immunoglobulin treatment, 3 had abnormalities of the coronary arteries. This is a significantly higher proportion of patients with a high ASO titer (n=3, 27.3%) than those with a normal ASO titer (n=53 [7.4%], P =0.047). A severe clinical course was seen in 81.8% of patients in the high ASO group versus 14.5% of patients in the normal ASO group. Conclusion It is not certain whether acute streptococcal infection may cause KD, but this study revealed that KD with high ASO titers showed higher rates of severe clinical course. It may be helpful to analyze concurrent streptococcal infection in patients with a severe clinical course.

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How to use antistreptolysin O titre

Cited by 21 publications

References 24 publications

Alterations in the Nervous System and Gut Microbiota after β-Hemolytic Streptococcus Group A Infection—Characteristics and Diagnostic Criteria of PANDAS Recognition

Alterations in the Nervous System and Gut Microbiota after β-Hemolytic Streptococcus Group A Infection—Characteristics and Diagnostic Criteria of PANDAS Recognition

Clinical Characterics, Laboratory Features, and Management of Odontogenic Facial Cellulitis

High antistreptolysin O titer is associated with coronary artery lesions in patients with Kawasaki disease

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