How useful is your X in discerning pedigrees?

Gomes, Cláudia; Magalhães, Marta; Amorim, António; Alves, Cı́ntia; Pinto, Nádia; Gusmão, Leonor

doi:10.1016/j.fsigss.2011.08.081

Cited by 6 publications

(3 citation statements)

References 3 publications

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“…X-STR haplotyping can be of particular help in kinship testing with deficient paternity cases where a DNA sample from one of the parents is not available for testing. For example, if a father/daughter parentage relationship is in question, X-STRs may be helpful [53][54][55][56][57].…”

Section: X-chromosomal Strs and Ministrs: Identity Testing And Beyondmentioning

confidence: 99%

Scope of X-Chromosomal MiniSTRs: Current Developments

Israr¹

2014

J Forensic

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The experience of using autosomal short-length amplicon STRs or miniSTRs in profiling of degraded DNA and mass disaster victims is extended into the realm of X-chromosomal (ChrX) STR miniaturization. About half of the total X-STRs are now short-length amplicons and the focus is shifting to using the mini versions of all of them. Joint multiplexing of these loci can be used for solving complex paternity cases and association of mass disaster victims with their families. This technology may herald a new dimension for research in population genetics and evolution. We present an overview of the progress made thus far and the future scope and prospects for X-miniSTRs.

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Section: X-chromosomal Strs and Ministrs: Identity Testing And Beyondmentioning

confidence: 99%

Scope of X-Chromosomal MiniSTRs: Current Developments

Israr¹

2014

J Forensic

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“…Indeed, X-chromosome T polymorphisms are progressively an indispensable tool in the routine context of a forensic laboratory, complementing the information obtained with autosomal markers. On the other hand, X-markers have higher mean exclusion chance (MEC) [2], allowing to solve certain kinship questions, inaccessible with autosomal markers [3,4]. Previous studies on other European populations [1] indicate these set of 32 -X-InDel polymorphisms as a proficient tool when dealing with kinship analysis, showing a significant MEC values, both for duos, as for trios.…”

Section: Introductionmentioning

confidence: 99%

X-InDels efficacy evaluation in a critical samples paternity case: A Spanish Civil War case from the memorial of the camposines (Tarragona, Spain)

Gomes

Palomo-Díez

Baeza-Richer

et al. 2019

Forensic Science International: Genetics Supplement Series

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The Memorial of the Camposines (la Fatarella, Tarragona, Spain) consists in a place that honours all combatants of the Spanish Civil War (1936)(1937)(1938)(1939), without distinction of sides. The site was included in the research carried out by the multidisciplinary team coordinated by the program of the General Directorate of Democratic Memory, Generalitat of Catalonia, Spain, for the identification of the victims of the Spanish Civil War. The case investigated on the present study consisted on a presumable paternity. To accomplish the study of the presumptive father critical samples, one of the combatants found on the Memorial, two bone samples were selected -a petrous portion of left temporal bone, and a condyle of foramen magnum, both fractured and at a very bad stage of conservation. After a specific DNA extraction for critical bone sample, the next step was an autosomal and Ychromosome analysis, trying to find a possible coincidence with any possible familiar, from the familial database. A potential match was found, indicating a possible living daughter. However, between both autosomal profiles one Mendelian incompatibility was detected, and also several allelic dropout phenomena in the presumptive father's profile. Therefore, samples were analysed for a 32 X-chromosome Insertion-Deletion (InDel) polymorphisms battery, assessing their ability to solve, or at least complementing autosomal information, in a complex paternity case.It was possible to confirm the efficacy of these 32 X-InDels polymorphisms, by solving undoubtedly the case. Due to the five incompatibilities detected between both X-InDels profiles, it was now possible to discard immediately a possible paternity case.

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“…ChrX STRs can, however, only be used in paternity case disputes involving daughters, as there is no allele inherited by descent in a father-son relationship. As ChrX STRs are located on a single chromosome, investigators must take the proper precautions when using these markers for genotyping and need to take into consideration genetic linkage and possible linkage disequilibrium amongst them ( Edelmann et al , 2004 , Gomes et al , 2011 ; Pinto et al , 2011 ).…”

mentioning

confidence: 99%

Impact of a chromosome X STR Decaplex in deficiency paternity cases

2013

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Deficiency paternity cases, characterized by the absence of the alleged father, are a challenge for forensic genetics. Here we present four cases with a female child and a deceased alleged father in which the analysis of a set of 21 or 22 autosomal STRs (AS STRs) produced results within a range of doubt when genotyping relatives of the alleged father. Aiming to increase the Paternity Index (PI) and obtain more reliable results, a set of 10 X-linked STR markers, developed by the Spanish and Portuguese Group of the International Society for Forensic Genetics (ISFG), was then added. Statistical analysis substantially shifted the results towards the alleged fatherhood in all four cases, with more dramatic changes when the supposed half-sister and respective mother were the relatives tested.

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How useful is your X in discerning pedigrees?

Cited by 6 publications

References 3 publications

Scope of X-Chromosomal MiniSTRs: Current Developments

Scope of X-Chromosomal MiniSTRs: Current Developments

X-InDels efficacy evaluation in a critical samples paternity case: A Spanish Civil War case from the memorial of the camposines (Tarragona, Spain)

Impact of a chromosome X STR Decaplex in deficiency paternity cases

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