Hox genes and patterning the vertebrate body

Wellik, Deneen M.

doi:10.1016/bs.ctdb.2024.02.011

Current Topics in Developmental Biology

2024

DOI: 10.1016/bs.ctdb.2024.02.011

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Hox genes and patterning the vertebrate body

Deneen M. Wellik

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2024

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Single-cell Transcriptomic Studies Unveil Potential Nodes of the Notochord Gene Regulatory Network

Negrón-Piñeiro,

Di Gregorio

2024

Integrative and Comparative Biology

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Transcription factors (TFs) are DNA-binding proteins able to modulate the timing, location and levels of gene expression by binding to regulatory DNA regions. Therefore, the repertoire of notochord TFs present in the genome of a multicellular organism and the expression of variable constellations of TFs in different cellular cohorts determine the distinctive characteristics of developing tissues and organs. The information on tissue-specific assortments of TFs, their cross-regulatory interactions, and the genes/regulatory regions targeted by each TF is summarized in gene regulatory networks (GRNs), which provide genetic blueprints for the specification, development and differentiation of multicellular structures. In this study, we review recent transcriptomic studies focused on the complement of TFs expressed in the notochord, a distinctive feature of all chordates. We analyzed notochord-specific datasets available from organisms representative of the three chordate subphyla, and highlighted lineage-specific variations in the suite of TFs expressed in their notochord. We framed the resulting findings within a provisional evolutionary scenario, which allows the formulation of hypotheses on the genetic/genomic changes that sculpted the structure and function of this structure on an evolutionary scale.

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Single-cell Transcriptomic Studies Unveil Potential Nodes of the Notochord Gene Regulatory Network

Negrón-Piñeiro,

Di Gregorio

2024

Integrative and Comparative Biology

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show abstract

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Hox genes and patterning the vertebrate body

Cited by 1 publication

References 141 publications

Single-cell Transcriptomic Studies Unveil Potential Nodes of the Notochord Gene Regulatory Network

Single-cell Transcriptomic Studies Unveil Potential Nodes of the Notochord Gene Regulatory Network

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