2021
DOI: 10.1016/j.braindev.2020.12.010
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HPeV3-associated acute encephalitis/encephalopathy among Japanese infants

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Cited by 9 publications
(18 citation statements)
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“…Incidence of HPeV meningitis in the Asian continent has been studied mainly in Japan and Korea [ 27 – 34 ]. A multicentre study, conducted in Japan identified 240 infants with HPeV type 3 infection, of which 14.2% diagnosed with acute CNS infection [ 28 ]. Among 216 patients aged less than 4 months and hospitalised for fever, 110 were found to have a viral infection on serum or CSF, caused by HPeV in 60 cases [ 30 ].…”
Section: Discussionmentioning
confidence: 99%
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“…Incidence of HPeV meningitis in the Asian continent has been studied mainly in Japan and Korea [ 27 – 34 ]. A multicentre study, conducted in Japan identified 240 infants with HPeV type 3 infection, of which 14.2% diagnosed with acute CNS infection [ 28 ]. Among 216 patients aged less than 4 months and hospitalised for fever, 110 were found to have a viral infection on serum or CSF, caused by HPeV in 60 cases [ 30 ].…”
Section: Discussionmentioning
confidence: 99%
“…Of 81 reports analysed, 47 dealt with the clinical presentation of HPeV meningeal infection [ 1 , 8 12 , 14 , 17 , 21 , 23 , 25 28 , 32 , 33 , 41 , 44 – 73 ].…”
Section: Discussionmentioning
confidence: 99%
“…9 In a case series from Japan, of 17 neonates with HPeV encephalitis who had abnormal neuroimaging, 4 had developmental abnormalities identified at follow-up; however, there was no correlation between MRI severity and developmental outcomes. 10 In experimental cell-culture and animal models, neuronal damage from HPeV3 resulted from infection-induced interferon and cytokine expression as confirmed by RT-PCR in the affected neurons with resultant increased expression of cell-death cytokines (as confirmed by Western blot) leading to activation of apoptosis, autophagy, and pyroptosis, though the full mechanism of HPeV3 pathogenesis is still being investigated. 13 Infection with HPeV, particularly serotype HPeV3, should be considered in any infant less than 3 months of age presenting with sepsis and signs of meningoencephalitis and/or seizures.…”
Section: Denouementmentioning
confidence: 98%
“…Importantly, in contrast to neonatal EV, these infants with HPeV meningoencephalitis typically have no CSF pleocytosis, though they may have elevated CSF protein. 1,5,9,10…”
Section: Denouementmentioning
confidence: 99%
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