HPTLC and RP-HPLC methods for simultaneous determination of Paracetamol and Pamabrom in presence of their potential impurities

Abdelaleem, Eglal A.; Naguib, Ibrahim A.; Hassan, Eman S.; Ali, Nouruddin W.

doi:10.1016/j.jpba.2015.04.043

Cited by 44 publications

(13 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…show a satisfactory determination of PCM without significant matrix effects. The presented method is promising due to some advantages such as lower LOD compared to available studies in the literature, 9,16,19,21,22,28,29 wider linear dynamic range than reported results 11,12,63 and employing the samples containing diverse matrix effect compared to available studies. 10,17,20,30 Furthermore, this investigation is rapid, simple, and cheaper compared to methods reported in the literature.…”

Section: Sample Analysismentioning

confidence: 87%

“…Therefore, measurement of the intensity of emitting radiation is employed for the analytical purpose 6 and has shown to be effective for the detection of PCM. 5,7 Several analytical methods have been presented for the measurement of PCM, such as: fluorimetry, 8 electrochemical, [9][10][11][12][13] spectrophotometry, [14][15][16] flow injection analysis (FIA), 17,18 chromatography, [19][20][21] and capillary electrophoresis. 22 CL can offer several advantages over these methods such as: the innate high sensitivity, low noise, low detection limit, and wide dynamic range.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Enhanced chemiluminescence determination of paracetamol

Emdadi

Sorouraddin

Denanny

2021

Analyst

View full text Add to dashboard Cite

show abstract

Section: Sample Analysismentioning

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Enhanced chemiluminescence determination of paracetamol

Emdadi

Sorouraddin

Denanny

2021

Analyst

View full text Add to dashboard Cite

show abstract

“…Numerous analytical approached have been investigated to determine the paracetamol in pure form, drug formulations and, biological fluids such as chromatography (Abdelaleem, Naguib, Hassan, & Ali, 2015;Belal, Awad, & Clark, 2009;Shaikh & Devkhile, 2008), flow injection (Calatayud, Pascual Marti, & Vives, 1986;Frangu, Pravcová, Šilarová, Arbneshi, & Sýs, 2019;Tzanavaras & Themelis, 2007), voltammetry (Goyal, Gupta, & Chatterjee, 2010), and spectrophotometry (Hoang, Ly, Tho, & Minh Thi Nguyen, 2014). Most of the spectrophotometric determination methods depended on hydrolysis of paracetamol into p-aminophenol in an acid medium.…”

Section: Introductionmentioning

confidence: 99%

Oxidative Coupling-Base Reaction for the Indirect Spectrophotometric Determination of Paracetamol in Drug Formulations

Thanoon

Raheed

Hasan

2021

IJONEST

View full text Add to dashboard Cite

A simple, rapid, and specific spectrophotometric method was developed for the determination of paracetamol in pure form and drug formulations. The method depended on the hydrolysis of paracetamol to p-aminophenol, which, oxidized under the effect of dissolved oxygen to benzoquinoneimine. In the alkaline medium, benzoquinoneimine reacts with Methyldopa to produce a high stabile indophenol dye. The absorbance was measured at 580 nm, and the molar absorptivity was found to be 7.75 x 10-5 L/(mol cm). Paracetamol was determined in pharmaceutical products in the 10–100 μg.mL-1 concentration range with a detection limit of 1.5 μg.mL-1 PAP. The developed method can be applied to the determination of both paracetamol and p-aminophenol in the presence of each other without prior separation. The proposed method is successfully employed for the determination of paracetamol in various synthetic mixtures and pharmaceutical preparations. Our obtained results were statistically compared with those given by the similar methods and the procedures evaluated as regards to both figures of merit and ease of applicability.

show abstract

“…Simultaneous determination of PCA with both PAP and PNP was performed by applying various separation techniques such as conventional high-performance liquid chromatography (HPLC) [15,16] or by using microemulsion liquid chromatography and micellar electrokinetic capillary chromatography [8]. The assay of PCA with PAP and/or other impurities was carried out using HPLC [7,[17][18][19][20], micellar electro kinetic capillary chromatography [21], and thin-layer chromatography densitometry [20,22]. Moreover, some electrochemical methods [23][24][25][26] were also applied to quantify the formerly mentioned analytes.…”

Section: Introductionmentioning

confidence: 99%

Analysis of some pharmaceuticals in the presence of their synthetic impurities by applying hybrid micelle liquid chromatography

El-Sherbiny

Wahba

2020

Open Chemistry

View full text Add to dashboard Cite

AbstractA stability-indicating hybrid micelle liquid chromatography accompanied by UV detection was developed for the simultaneous analysis of either paracetamol (PCA) or pseudoephedrine hydrochloride (PSU) with their synthetic impurities. Mixture I contains PCA with p-amino phenol and p-nitro phenol, while mixture II involves the estimation of PSU with benzaldehyde and benzoic acid. Both mixtures were separated using a C18 column that was thermostatically maintained at 40°C and operating under a flow rate of 1.5 mL/min, applying UV detection at 240 nm for mixture I and 220 nm for mixture II. In both cases, the mobile phase consisted of 0.1 M sodium dodecyl sulfate, acetonitrile, and triethylamine (90:10:0.3, v/v/v) and adjusted to pH 4 (mixture I) or pH 3.7 (mixture II) using 2.0 M O-phosphoric acid. The proposed method was validated and successfully applied to assay different pharmaceuticals containing PCA or PSU. Moreover, the stability-indicating nature of the proposed method was proved through applying photolytic degradation procedures for PCA.

show abstract

HPTLC and RP-HPLC methods for simultaneous determination of Paracetamol and Pamabrom in presence of their potential impurities

Cited by 44 publications

References 1 publication

Enhanced chemiluminescence determination of paracetamol

Enhanced chemiluminescence determination of paracetamol

Oxidative Coupling-Base Reaction for the Indirect Spectrophotometric Determination of Paracetamol in Drug Formulations

Analysis of some pharmaceuticals in the presence of their synthetic impurities by applying hybrid micelle liquid chromatography

Contact Info

Product

Resources

About