HPTLC–MS method for the determination of benzodiazepines in urine samples

Development and validation of the UPLC-MS method for simultaneous determination of six new psychoactive substances

“…, posing unprecedented challenges to public health and law enforcement everywhere. 17,23 Therefore, it is particularly important to be able to quantitatively monitor the content of benzodiazepines and antipsychotics in body fluids.…”

“…[23][24][25] As a result, two types of drugs are also oen associated with various types of crime for different purposes, such as sexual assault, murder, robbery, assault, etc., posing unprecedented challenges to public health and law enforcement everywhere. 17,23 Therefore, it is particularly important to be able to quantitatively monitor the content of benzodiazepines and antipsychotics in body uids.…”

“…[20][21][22] In addition, it is more serious that it will produce superimposed effect, leading to acute symptoms such as liver lung injury and even death if the two drugs are taken at the same time. [23][24][25] As a result, two types of drugs are also oen associated with various types of crime for different purposes, such as sexual assault, murder, robbery, assault, etc., posing unprecedented challenges to public health and law enforcement everywhere. 17,23 Therefore, it is particularly important to be able to quantitatively monitor the content of benzodiazepines and antipsychotics in body uids.…”

“…However, this technique has the disadvantages of complex and time-consuming, which is not suitable for routine drug screening in clinical and forensic toxicology. Choudhary 23 developed a high performance thin layer chromatography mass spectrometry (HPTLC-MS) method with the advantage of low operating cost to detect benzodiazepines. Nevertheless, it is not able to detect multiple substances simultaneously.…”