HPV genotypes and their prognostic significance in head and neck squamous cell carcinomas

18F-FDG PET/CT following chemoradiation of uterine cervix cancer provides powerful prognostic stratification independent of HPV status: a prospective cohort of 105 women with mature survival data

“…Two particular HPV species, alpha-7 (HPV 18, 39, 45, 59, 68 and 70) and alpha-9 (HPV 16, 31, 33, 35, 52, 58 and 67), have been found in over 80 % of all patients with cervical cancer. HPV infection status is postulated to directly influence the likelihood of response to chemoradiation therapy in other malignancies such as head and neck cancers [23,24]. In our study, the likelihood of metabolic response was not different between the higher-risk HPV group (71 % CMR) and the lower-risk HPV group (75 % CMR, p=0.83), and there was no significant difference in in-field metabolic control (p=0.29).…”

HPV Infections in Heterosexual Couples: Mechanisms and Covariates of Virus Transmission

“…Fundamental issues might be linked with immune responses and diverse responses of the genders. Also, the difference between the anatomical sites and their immunological response is not yet completely understood; low-risk HPV infection may act differently between sites [47] and may have an impact on the natural course of HPV infection. Furthermore, the role of other types than α-HPV genotypes may influence the infection [6] as well as inclusion of HPV molecular variants.…”

Do high-risk human papillomaviruses cause oral cavity squamous cell carcinoma?

“…Many studies [16][17][18][19][20][21][22][23][24][25][26][27][28][29] have identified a high proportion of OCSCC with detectable HPV DNA (Table 1). In a recent systematic review, summarizing 60 publications on 4195 patients with OCSCC, Isayeva et al [30] found that 705 (16.8%) of these tumors contained HPV DNA especially the HPV16 genotype.…”