HPV genotyping and p16 expression in Xingu Indigenous Park, Brazil

Freitas, V G; Focchi, Gustavo Rubino de Azevedo; Pereira, Ediléa Dutra; Levi, José Eduardo; Speck, Neila Maria de Góis; Ribalta, Julisa Chamorro Lascasas

doi:10.4238/gmr.15036840

Cited by 2 publications

(3 citation statements)

References 33 publications

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“…In Xingu, it was reported the prevalence of HPV 52 and HPV types of possible high oncogenic risk in high grade lesions, inferring the possibility of a different epidemiological profile than expected. Consequently, the efficacy of immunization through the quadrivalent or nonvalent vaccine in this population should be considered judiciously [2]. In conclusion, the paradigm that organization is indeed the best step to implement cancer prevention was demonstrated.…”

Section: Igrwh000559 3(2)2019mentioning

confidence: 95%

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Impact of Cervix Uterine Cancer Screening in the Indian Park of Xingu

et al. 2019

IGRWH

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Background: There are few exploratory studies on Human Papillomavirus (HPV) infection and cervical cancer in indigenous populations. Because these women represent a very peculiar population in terms of habits and cultural rituals of its own, HPV infection and its related-oncogenesis potential could not denote the same progression characteristics as compared to the other populations commonly studied. The aim of this study was to evaluate 13 years of cervical cancer screening actions and assistance in the Xingu Indigenous Park, through cytological analysis and DNA-HPV molecular test.Methods: This is an observational, transversal and retrospective study conducted by data analysis of screening and control actions of uterine cervical HPV-associated lesions in the scope of the Xingu project supported by the Universidad Federal de São Paulo (UNIFESP), Brazil. The population studied consisted of indigenous, sexually active women, aged 11 years or older, belonging to sixteen ethnic groups residing in the middle, lower and east Xingu regions. The women were screening for conventional cervical screening test (Pap test) and HPV tests. Results:The population coverage for cytological analyses in the entire period averaged 89.4%. Only 3 cases of cervical cancer were documented over the 13 years of follow-up. The HPV positivity rate was 24.5% and latency 22.9%. Conclusions:It was observed that the high coverage of the population was valuable in maintaining the quality of screening because of the large number of normal Pap tests and rare cases of cancer compared to the national incidence.

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Section: Igrwh000559 3(2)2019mentioning

confidence: 95%

“…among others [1,2]. In addition, available epidemiological data are insufficient to assess the health problems of the female population and of indigenous adolescents [3].…”

Section: Igrwh0005559 3(2)2019mentioning

confidence: 99%

Impact of Cervix Uterine Cancer Screening in the Indian Park of Xingu

et al. 2019

IGRWH

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“…Regarding the analysis of CT detection, it was observed that 1.8% (18) of women were positive. The distribution analysis by XIP region showed that 38.9% (7) were from Lower Xingu, 27.8% (5)…”

Section: Ethics Approvalmentioning

confidence: 99%

Chlamydia trachomatis, Neisseria gonorrhoeae and human papillomavirus infections of lower genital tract of Indigenous women from Xingu Indigenous Park

Correa Porto,

Longatto-Filho,

De Almeida

et al. 2023

RRH

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Introduction: Xingu Indigenous Park (XIP) currently protects 16 ethnic Indigenous groups and is located in the central area of Brazil. XIP is the first and the largest Indigenous land to be recognized in the country. Community access is limited and restricted for the non-Indigenous population, and the Indigenous women are constantly dealing with shortages of medical care.High-risk human papillomavirus (HR-HPV) is the most common cause of cervical cancer and is detected in 99% of cervical precancers. HPV infections may be associated with bacterial agents such as Chlamydia trachomatis and Neisseria gonorrhoeae, which are also important causative agents of sexually transmitted infections and are responsible for the most frequent bacterial infections in the world. The present study evaluated the frequency and potential impact of Chlamydia trachomatis, Neisseria gonorrhoeae, and HR-HPV in the Indigenous women of XIP. Methods:In this cross-sectional study, 992 cervical-vaginal samples were collected from Indigenous women, using a Cervex-Brush, and were immediately placed in a SurePath medium. All samples were submitted to the cobas® 4800 detection system for the identification of 14 different types of HR-HPV, and the multiplex Abbott RealTime CT/NG assay for the detection of Chlamydia trachomatis and Neisseria gonorrhoeae.Results: HR-HPV was detected in 18.2% of women; 6% were positive for HPV16, 5% for HPV18, and 81% for other types of HR-HPV. Co-infections of HPV16 and other types was observed in 5% of women, and 3% had co-infections of HPV18 and other types. Moreover, 1.8% of women were positive for Chlamydia trachomatis, while Neisseria gonorrhoeae was not detected. In women with HR-HPV, 33% had Chlamydia trachomatis infections, 28% were positive for HR-HPV other than HPV16 or HPV18, and 5% had co-infections of HPV16 and the other types of HPV.Younger women were found to be more susceptible to HPV infections. Conclusion:The findings indicate a high frequency of HR-HPV and a considerable frequency of Chlamydia trachomatis in the Indigenous women of XIP. The detection of Chlamydia trachomatis, Neisseria gonorrhoeae, and/or HR-HPV does not present evidence of a potential interrelationship for a combined pathogenic action in these women.

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HPV genotyping and p16 expression in Xingu Indigenous Park, Brazil

Cited by 2 publications

References 33 publications

Impact of Cervix Uterine Cancer Screening in the Indian Park of Xingu

Impact of Cervix Uterine Cancer Screening in the Indian Park of Xingu

Chlamydia trachomatis, Neisseria gonorrhoeae and human papillomavirus infections of lower genital tract of Indigenous women from Xingu Indigenous Park

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