HPV prevalence and prognostic value in a prospective cohort of 255 patients with locally advanced squamous cell carcinoma of the head and neck treated with chemoradiation therapy at Centre Hospitalier de l'Université de Montréal: A single-center experience.

Thibaudeau, E.; Soulières, Denis; Fortin, B.; Coutlée, François; Nguyen-Tân, Phuc Félix; Weng, Xiuhua; Audette, Melanie C.; Abboud, Olivier; Guertin, Louis; Christopoulos, Apostolos; Tabet, Jean‐Claude

doi:10.1200/jco.2011.29.15_suppl.5574

Cited by 2 publications

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“…HPV-Diagnostik ist die Kombination aus HPV-PCR und p16-Immunhistochemie Vor Kurzem wurde an der Universitäts-klinik in Montreal eine prospektive Studie mit 560 Patienten durchgeführt [13]. In dieser Studie wurden die Patienten mit gleichzeitiger platinbasierter Radiochemotherapie behandelt.…”

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Neue Aspekte HPV-positiver Kopf-Hals-Karzinome

Kofler

Uecker

Muenscher

et al. 2012

HNO

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HPV-positive head and neck carcinoma is significantly different than tobacco- and alcohol-induced cancer. Between 30% and 50% of oropharyngeal cancers are associated with human papillomavirus (HPV). Studies still show an increasing incidence. HPV-positive head and neck cancer patients have a better prognosis due to a better response to therapy. Especially patients with gene overexpression of immunological proteins in the antigen presentation are suggested to benefit from radiotherapy. A current retrospective study shows better outcomes for patients treated with radiotherapy in combination with biological targets compared to radiochemotherapy.

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“…Details wurden im Abstract nicht genannt. Somit veranschaulicht diese Studie, dass der HPV-Status mit der Prognose bei Patienten, welche eine Radiochemotherapie erhalten haben, korreliert [13].…”

Section: » Goldstandard In Derunclassified

Neue Aspekte HPV-positiver Kopf-Hals-Karzinome

Kofler

Uecker

Muenscher

et al. 2012

HNO

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Prevalence of Alpha, Beta, and Gamma Human Papillomaviruses in Patients With Head and Neck Cancer and Noncancer Controls and Relation to Behavioral Factors

Al-Soneidar

Harper

Coutlée

et al. 2023

The Journal of Infectious Diseases

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Objectives Human papillomaviruses (HPV) cause head and neck cancer (HNC) that is increasing in incidence in developed countries. We investigate the prevalence of alpha (α-), beta (β)-, and gamma (γ) HPV among HNC cases and controls, and their relationship with sociodemographic, behavioral and oral health factors. Methods We obtained oral rinse and brush samples from incident HNC cases (n = 369) and hospital-based controls (n = 439), and tumor samples for a subsample of cases (n = 121). We genotyped samples using PCR with PGMY09-PGMY11 primers and Linear Array for α-HPV and type-specific multiplex (TS-MPG) for β-HPV and γ-HPV. Sociodemographic and behavioral data were obtained from interviews. Results The prevalence of α-, β-, and γ-HPV among controls was 14%, 56%, and 24%, respectively, whereas among cases was 42%, 50%, and 33%, respectively. Prevalence of α- and γ-HPV, but not β-HPV, increased with the increase in sexual activity, smoking, and drinking habits. No HPV genus was associated with oral health. Tumor samples included HPV genotypes exclusively from the α-genus, mostly HPV16, in 80% of cases. Conclusions The distribution of α- and γ-HPV, but not β-HPV, seems to vary based on sociodemographic and behavioral characteristics. We did not observe the presence of cutaneous HPV in tumor tissues.

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HPV prevalence and prognostic value in a prospective cohort of 255 patients with locally advanced squamous cell carcinoma of the head and neck treated with chemoradiation therapy at Centre Hospitalier de l'Université de Montréal: A single-center experience.

Cited by 2 publications

References 0 publications

Neue Aspekte HPV-positiver Kopf-Hals-Karzinome

Neue Aspekte HPV-positiver Kopf-Hals-Karzinome

Prevalence of Alpha, Beta, and Gamma Human Papillomaviruses in Patients With Head and Neck Cancer and Noncancer Controls and Relation to Behavioral Factors

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