HPV vaccinations: a Middle Eastern and north African dilemma

Baghi, Hossein Bannazadeh; Yousefi, Bahman; Oskouee, Mahin Ahangar; Aghazadeh, Mohammad

doi:10.1016/s1473-3099(16)30553-9

Cited by 24 publications

(10 citation statements)

References 4 publications

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“…However, some HPV genotypes, for example, HPV53 (probably HR), HPV31 (HR), HPV51 (HR), and HPV52 (HR) were also common in various ethnicities and continents. Overall, our findings were consistent with other scientific reports but a larger sample size of population study, genotyping with an approved diagnostic assay, and sequencing were advantages of the study 29,31,34,35,[45][46][47][48]. F I G U R E 4 Phylogenetic tree constructed from the L1 (major capsid protein) nucleotide sequence of the isolated low-risk HPVs 6 and 11 genotypes from Iran and reference HPV genotypes.…”

supporting

confidence: 88%

Trends in cocirculation of oncogenic HPV genotypes in single and multiple infections among the unvaccinated community

Vazifehdoost

Eskandari²,

Sohrabi

2022

Journal of Medical Virology

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supporting

confidence: 88%

Trends in cocirculation of oncogenic HPV genotypes in single and multiple infections among the unvaccinated community

Vazifehdoost

Eskandari²,

Sohrabi

2022

Journal of Medical Virology

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“…Although traditional Arabic countries, including Oman, have a lower rate of HPV infections due to more conservative sexual behaviours, the prevalence of HPV infections is increasing at an alarming rate as a result of increased levels of sexual activity among the younger population (10-24 years old) (Baghi et al, 2017). Notably, the majority of women in these countries were not aware of the availability of the HPV vaccination, and/or did not accept the vaccine (Ortashi et al, 2013;Ortashi et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Knowledge of Cancer Risk Factors, Symptoms, and Barriers to Seeking Medical Help among Omani Adolescents

Al-Azri

Saadi

Al-Harrasi

et al. 2019

Asian Pac J Cancer Prev

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Objective:Raising cancer awareness among adolescents should lead to early diagnosis and improve their survival rate into adulthood. This study aims to identify knowledge of cancer risk factors, symptoms and barriers to seek medical help among Omani adolescents. Methods: A cross-sectional study with Omani adolescents (aged 15-17 years) has been conducted in six schools in Muscat, the capital of Oman. The general Cancer Awareness Measure questionnaire was used to collect the data. Results: A total of 481 adolescents participated. The average recognition of cancer risk factors and symptoms was low (36.8% and 39.6%, respectively). Cancer risk factors and/or symptoms significantly recognised more in girls compared to boys (χ 2 = 10.136; Odds ratio [OR] = 2.13 ; 95% confidence interval [CI]= 0.33-3.41; P = 0.001); older (age 17 year) versus younger (aged 15 and 16 years) (χ 2 = 6.075; OR = 11.68; 95% CI: 1.11-2.53; P = 0.014); those with existing co-morbidities compared to those without (χ 2 = 4.955; OR = 0.41; 95% CI: 0.18-0.92; P = 0.026); and those who knew someone with cancer compared to those who did not (χ 2 = 15.285; OR 2.70; 95% CI: 1.62-4.49; P <0.001). The majority of adolescents (88.8%) would seek medical help within the first two weeks of noting cancer symptoms. The most notable barriers to seek medical help were "emotional". Girls were experienced "emotional barriers" significantly more than the boys (χ 2 = 11.617; OR = 1.89; 95% CI: 1.31-2.72; P = <0.001). Conclusion: Adolescents in Oman showed poor cancer awareness with several "emotional" barriers. There is a need to establish and integrate effective cancer educational programs in school curriculums to raise the cancer awareness, address emotional barriers and encourage seeking early medical help. The program could potentially have a life-long impact on encouraging early cancer diagnosis and improving the cancer survival rate.

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“…HPVs are double-stranded DNA viruses that belong to a family of Papovaviridae, including approximately 150 HPV types recognized so far. HPV can be classified into low-risk groups causing genital warts (like penis, anus, and vulva) and high-risk groups causing the various type of cancers, most commonly female cervical cancers ( Baghi et al., 2017 ). HPV-16 and HPV-18 are the most investigated types.…”

Section: Applications Of Crispr/cas Technology In Targeting Viral And...mentioning

confidence: 99%

The State-of-the-Art of Gene Editing and its Application to Viral Infections and Diseases Including COVID-19

Hawsawi

Shams

Theyab

et al. 2022

Front. Cell. Infect. Microbiol.

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Gene therapy delivers a promising hope to cure many diseases and defects. The discovery of gene-editing technology fueled the world with valuable tools that have been employed in various domains of science, medicine, and biotechnology. Multiple means of gene editing have been established, including CRISPR/Cas, ZFNs, and TALENs. These strategies are believed to help understand the biological mechanisms of disease progression. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been designated the causative virus for coronavirus disease 2019 (COVID-19) that emerged at the end of 2019. This viral infection is a highly pathogenic and transmissible disease that caused a public health pandemic. As gene editing tools have shown great success in multiple scientific and medical areas, they could eventually contribute to discovering novel therapeutic and diagnostic strategies to battle the COVID-19 pandemic disease. This review aims to briefly highlight the history and some of the recent advancements of gene editing technologies. After that, we will describe various biological features of the CRISPR-Cas9 system and its diverse implications in treating different infectious diseases, both viral and non-viral. Finally, we will present current and future advancements in combating COVID-19 with a potential contribution of the CRISPR system as an antiviral modality in this battle.

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HPV vaccinations: a Middle Eastern and north African dilemma

Cited by 24 publications

References 4 publications

Trends in cocirculation of oncogenic HPV genotypes in single and multiple infections among the unvaccinated community

Trends in cocirculation of oncogenic HPV genotypes in single and multiple infections among the unvaccinated community

Knowledge of Cancer Risk Factors, Symptoms, and Barriers to Seeking Medical Help among Omani Adolescents

The State-of-the-Art of Gene Editing and its Application to Viral Infections and Diseases Including COVID-19

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