HSF1 and HSPA6 as functional candidate genes associated with heat tolerance in Angus cattle

Baena, Marielle Moura; Tizioto, Polyana C.; Meirelles, Sarah Laguna Conceição; Regitano, Luciana Correia de Almeida

doi:10.1590/rbz4720160390

Cited by 23 publications

(14 citation statements)

References 31 publications

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“…Respiration rate and body core temperature have been recommended as suitable parameters to assess individual heat loads of dairy cows at an early stage, whereas feeding behaviour may depend on the physiological stage of the cow [66]. In mammals, exposure to hypothermia or hyperthermia has been related to morphological and physiological alterations [67]. In the present study, we observed that almost all the cows sought shade as the heat intensity increased, indicating obvious distress and a search for shelter from the direct sun.…”

Section: Discussionmentioning

confidence: 99%

Heat Stress Impacts on Lactating Cows Grazing Australian Summer Pastures on an Automatic Robotic Dairy

Osei-Amponsah

Dunshea

Leury

et al. 2020

Animals

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The objective of this study was to measure the impacts of summer heat events on physiological parameters (body temperature, respiratory rate and panting scores), grazing behaviour and production parameters of lactating Holstein Friesian cows managed on an Automated Robotic Dairy during Australian summer. The severity of heat stress was measured using Temperature-Humidity Index (THI) and impacts of different THIs—low (≤72), moderate (73–82) and high (≥83)—on physiological responses and production performance were measured. There was a highly significant (p ≤ 0.01) effect of THI on respiratory rate (66.7, 84.7 and 109.1/min), panting scores (1.4, 1.9 and 2.3) and average body temperature of cows (38.4, 39.4 and 41.5 °C), which increased as THI increased from low to moderate to high over the summer. Average milk production parameters were also significantly (p ≤ 0.01) affected by THI, such that daily milk production dropped by 14% from low to high THI, milk temperature and fat% increased by 3%, whilst protein% increased by 2%. The lactation stage of cow had no significant effect on physiological parameters but affected (p ≤ 0.05) average daily milk yield and milk solids. Highly significant (p ≤ 0.01) positive correlations were obtained between THI and milk temperature, fat% and protein% whilst the reverse was observed between THI and milk yield, feed intake and rumination time. Under moderate and high THI, most cows sought shade, spent more time around watering points and showed signs of distress (excessive salivation and open mouth panting). In view of the expected future increase in the frequency and severity of heat events, additional strategies including selection and breeding for thermotolerance and dietary interventions to improve resilience of cows need to be pursued.

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Section: Discussionmentioning

confidence: 99%

Heat Stress Impacts on Lactating Cows Grazing Australian Summer Pastures on an Automatic Robotic Dairy

Osei-Amponsah

Dunshea

Leury

et al. 2020

Animals

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“…This study predicted a putative novel HSPE1 transcript with alternative 5′ splice site more expressed in HIF animals. SNPs (Single nucleotide polymorphisms) found in HSP family genes were associated with thermal tolerance traits in Chinese Holstein 56 and Angus cattle 57 . Heat shock proteins provide subsidies for cells to identify and promote the refolding of damaged proteins or target them to appropriate proteolytic systems, thereby helping to eliminate proteins whose damage is not suitable for recovery.…”

Section: Discussionmentioning

confidence: 99%

Spliced genes in muscle from Nelore Cattle and their association with carcass and meat quality

Silva

Fonseca

Pinheiro

et al. 2020

Sci Rep

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Transcript data obtained by RNA-Seq were used to identify differentially expressed alternatively spliced genes in ribeye muscle tissue between Nelore cattle that differed in their ribeye area (REA) or intramuscular fat content (IF). A total of 166 alternatively spliced transcripts from 125 genes were significantly differentially expressed in ribeye muscle between the highest and lowest REA groups (p ≤ 0.05). For animals selected on their IF content, 269 alternatively spliced transcripts from 219 genes were differentially expressed in ribeye muscle between the highest and lowest IF animals. Cassette exons and alternative 3′ splice sites were the most frequently found alternatively spliced transcripts for REA and IF content. For both traits, some differentially expressed alternatively spliced transcripts belonged to myosin and myotilin gene families. The hub transcripts were identified for REA (LRRFIP1, RCAN1 and RHOBTB1) and IF (TRIP12, HSPE1 and MAP2K6) have an important role to play in muscle cell degradation, development and motility. In general, transcripts were found for both traits with biological process GO terms that were involved in pathways related to protein ubiquitination, muscle differentiation, lipids and hormonal systems. Our results reinforce the biological importance of these known processes but also reveal new insights into the complexity of the whole cell muscle mRNA of Nelore cattle.

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“…Besides heat stress (Baena et al, 2018; Sales et al, 2018), heat shock proteins (HSP) are being evaluated in apoptosis, oxidative stress, inflammatory diseases, cancer (Ikwegbue et al, 2017), virus infection (Shan et al, 2018), bacterial infection (Kim et al, 2018), as immunomodulators (Edkins et al, 2017; Zininga et al, 2018), therapeutics (Skórzynska-Dziduszko et al, 2018), and diagnostics (Lechner et al, 2018; Tang T. et al, 2018). HSPs have diagnostic role in ischemic injury of cardiomyocytes (Santos et al, 2018), inflammatory process of multiple sclerosis (Lechner et al, 2018), early diagnosis of lung cancer (Tang T. et al, 2018), proteome stress (Liu and Zhang, 2018), bipolar disorder (Cheng et al, 2018), and anti-apoptotic agent (Jang et al, 2018).…”

Section: Heat Shock Proteins (Hsps)mentioning

confidence: 99%

Biomarkers in Stress Related Diseases/Disorders: Diagnostic, Prognostic, and Therapeutic Values

Dhama

Latheef

Dadar

et al. 2019

Front. Mol. Biosci.

220

172

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Various internal and external factors negatively affect the homeostatic equilibrium of organisms at the molecular to the whole-body level, inducing the so-called state of stress. Stress affects an organism's welfare status and induces energy-consuming mechanisms to combat the subsequent ill effects; thus, the individual may be immunocompromised, making them vulnerable to pathogens. The information presented here has been extensively reviewed, compiled, and analyzed from authenticated published resources available on Medline, PubMed, PubMed Central, Science Direct, and other scientific databases. Stress levels can be monitored by the quantitative and qualitative measurement of biomarkers. Potential markers of stress include thermal stress markers, such as heat shock proteins (HSPs), innate immune markers, such as Acute Phase Proteins (APPs), oxidative stress markers, and chemical secretions in the saliva and urine. In addition, stress biomarkers also play critical roles in the prognosis of stress-related diseases and disorders, and therapy guidance. Moreover, different components have been identified as potent mediators of cardiovascular, central nervous system, hepatic, and nephrological disorders, which can also be employed to evaluate these conditions precisely, but with stringent validation and specificity. Considerable scientific advances have been made in the detection, quantitation, and application of these biomarkers. The present review describes the current progress of identifying biomarkers, their prognostic, and therapeutic values.

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HSF1 and HSPA6 as functional candidate genes associated with heat tolerance in Angus cattle

Cited by 23 publications

References 31 publications

Heat Stress Impacts on Lactating Cows Grazing Australian Summer Pastures on an Automatic Robotic Dairy

Heat Stress Impacts on Lactating Cows Grazing Australian Summer Pastures on an Automatic Robotic Dairy

Spliced genes in muscle from Nelore Cattle and their association with carcass and meat quality

Biomarkers in Stress Related Diseases/Disorders: Diagnostic, Prognostic, and Therapeutic Values

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