HSP70 polymorphisms in first psychotic episode drug-naïve schizophrenic patients

Bozidis, Petros; Hyphantis, Thomas; Mantas, Christos; Sotiropoulou, Marianthi; Antypa, Niki; Andreoulakis, Elias; Serretti, Alessandro; Mavreas, Venetsanos; Αντωνίου, Κατερίνα

doi:10.1016/j.lfs.2014.02.006

Cited by 13 publications

(12 citation statements)

References 28 publications

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“…Protein interactions between PPM1B, NRG1, and DTNBP1, putative schizophrenia susceptibility genes, have also been reported (Tsuang, 2000). HSPA8 , associated with attention/vigilance and speed of processing, was previously identified as a schizophrenia risk locus (Bozidis et al, 2014). HSPA8, Heat shock 70 kDa protein 8, is known to contribute to many biological processes, including signal transduction, apoptosis, autophagy, protein homeostasis, and cell growth and differentiation.…”

Section: Discussionmentioning

confidence: 99%

Polygenic risk score, genome-wide association, and gene set analyses of cognitive domain deficits in schizophrenia

Nakahara

Medland

Turner

et al. 2018

Schizophrenia Research

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This study assessed genetic contributions to six cognitive domains, identified by the MATRICS Cognitive Consensus Battery as relevant for schizophrenia, cognition-enhancing, clinical trials. Psychiatric Genomics Consortium Schizophrenia polygenic risk scores showed significant negative correlations with each cognitive domain. Genome-wide association analyses identified loci associated with attention/vigilance (rs830786 within HNF4G), verbal memory (rs67017972 near NDUFS4), and reasoning/problem solving (rs76872642 within HDAC9). Gene set analysis identified unique and shared genes across cognitive domains. These findings suggest involvement of common and unique mechanisms across cognitive domains and may contribute to the discovery of new therapeutic targets to treat cognitive deficits in schizophrenia.

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Section: Discussionmentioning

confidence: 99%

Polygenic risk score, genome-wide association, and gene set analyses of cognitive domain deficits in schizophrenia

Nakahara

Medland

Turner

et al. 2018

Schizophrenia Research

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“…Moreover, non addicted patients in their first psychotic episode, scored higher in neuroticism than healthy participants [44], [45].…”

Section: Introductionmentioning

confidence: 87%

“…The relationship between neuroticism and psychotic symptoms, even the severity of these symptoms, has been studied previously in non-drug using populations [43] . Moreover, non addicted patients in their first psychotic episode, scored higher in neuroticism than healthy participants [44] , [45] .…”

Section: Introductionmentioning

confidence: 87%

Neuroticism Associated with Cocaine-Induced Psychosis in Cocaine-Dependent Patients: A Cross-Sectional Observational Study

et al. 2014

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BackgroundCocaine consumption can induce transient psychotic symptoms, which has been correlated with more severe addiction and aggressive behavior. However, little is known about the nature of the relationship between personality traits and psychotic symptoms in cocaine-dependent patients. This study examined the relationship between neuroticism and cocaine-induced psychosis.MethodsA total of 231 cocaine-dependent patients seeking treatment were recruited to the study. Personality was evaluated by the Zuckerman-Kuhlman Personality Questionnaire. Cocaine-induced psychosis questionnaire, SCID-I, and SCID-II were used to evaluate comorbidity and clinical characteristics. Data analysis was performed in three steps: descriptive, bivariate, and multivariate analyses.ResultsCocaine-induced psychosis was reported in 65.4% of the patients and some personality disorder in 46.8%. Two personality dimensions (Neuroticism-Anxiety and Aggression-Hostility) presented a significant effect on the risk of experiencing psychotic symptoms (t(229) = 2.69, p = 0.008; t(229) = 2.06, p = 0.004), and patients with psychotic symptoms showed higher scores in both variables. On the multivariate analysis, only Neuroticism remained as a significant personality factor independently associated with psychotic symptoms (Wald = 7.44, p<0.05, OR = 1.08, CI 95% 1.02–1.16) after controlling for age, gender and number of consumption substances.ConclusionsAn association between high neuroticism scores and presence of psychotic symptoms induced by cocaine has been found, independently of other consumption variables. Personality dimensions should be evaluated in cocaine-dependent patients in order to detect high scores of neuroticism and warn patients about the risk of developing cocaine-induced psychotic symptoms.

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“…APD-induced expression of HSPA8 and NPM1 was also observed in the sub-chronic APD-treated rat cortex. According to a recent study, a polymorphism in the HSPA8 gene (rs1136141) in patients with first-episode psychosis served as a risk factor for psychosis development [ 29 ]. Proteomic and epigenetic studies of postmortem brains also revealed downregulation of HSPA8 in patients with schizophrenia [ 10 , 30 ], as well as in patients with Alzheimer’s disease (AD) [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

Proteomic study revealed antipsychotics-induced nuclear protein regulations in B35 cells are similar to the regulations in C6 cells and rat cortex

Lee

Tsai

et al. 2018

BMC Pharmacol Toxicol

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BackgroundBased on accumulating evidence, the regulation of protein expression by antipsychotic drugs (APDs) might be closely related to the control of psychotic symptoms when these drugs are used to treat mental disorders. The low quantity of nuclear proteins in the cell hinders their detection because signal for rare proteins are masked in most proteomic detection systems.MethodsNuclear proteins fractionated from APD-treated B35 cells were labeled with iTRAQ and detected by LC/MS/MS to investigate APD-induced alterations in nuclear protein expression. Western blot, immunofluorescent cell staining, and immunohistochemical staining were applied to validate the findings.ResultsThe expression of ADP/ATP translocase 2, heat shock cognate 71 kDa protein, histone H1.2, histone H3.3, histone H4, non-POU domain-containing octamer-binding protein, nucleolin, nucleophosmin, prelamin-A/C, plectin-1, vimentin, and 40S ribosomal protein S3a was regulated by APDs in B35 cells, according to our proteomic data. According to the results of the gene ontology analysis, all these proteins played important roles in biological processes or in molecular functions in cells. Western blot results showing APD-induced alterations in nuclear protein expression in B35 cells were consistent with the LC/MS/MS results. Heat shock cognate 71 kDa protein and vimentin expression in C6 cells were not affected by the three APDs. As shown in the immunofluorescent cell staining, all the three APDs altered protein expression to similar extents. We also examined whether the expression of these proteins was affected by APDs in the prefrontal cortex of rats administered sub-chronic and chronic APD treatments by western blotting and immunohistochemical staining.ConclusionsThe findings of the proteomic analysis of APD-treated B35 cells were recapitulated in the APD-treated rat cortex. The expression of some proteins was altered by APDs in rat prefrontal cortex in a time-dependent manner.Electronic supplementary materialThe online version of this article (10.1186/s40360-018-0199-0) contains supplementary material, which is available to authorized users.

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HSP70 polymorphisms in first psychotic episode drug-naïve schizophrenic patients

Cited by 13 publications

References 28 publications

Polygenic risk score, genome-wide association, and gene set analyses of cognitive domain deficits in schizophrenia

Polygenic risk score, genome-wide association, and gene set analyses of cognitive domain deficits in schizophrenia

Neuroticism Associated with Cocaine-Induced Psychosis in Cocaine-Dependent Patients: A Cross-Sectional Observational Study

Proteomic study revealed antipsychotics-induced nuclear protein regulations in B35 cells are similar to the regulations in C6 cells and rat cortex

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