Hsv Infection is Associated with Gestational Hypertension: Results from the Us National Inpatient Sample

Shi, Li-feng; Wu, Yan Yan

doi:10.1136/jim-2017-000687

Cited by 5 publications

(2 citation statements)

References 19 publications

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“…The higher incidence of hypertension might be due to immunodeficiency and longdrawn-out antiretroviral therapy, and conventional risk factors of older age, male gender, and high body mass index 79 . Essential hypertension (EH) is associated with cytomegalovirus (CMV) infection 80 , and gestational hypertension is associated with herpes simplex virus infection, during pregnancy 81 . Pulmonary arterial hypertension is associated with some viral infections viz., human immunodeficiency virus (HIV), human herpesvirus-8, hepatitis B, and C 82 .…”

Section: Covid-19 and Hypertensionmentioning

confidence: 99%

COVID-19 and the World with Co-Morbidities of Heart Disease, Hypertension and Diabetes

Anand¹,

Sangeetha²,

Fathah³

et al. 2020

J Pure Appl Microbiol

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Newly emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing coronavirus disease 2019 (COVID-19) pandemic has now spread across the globe in past few months while affecting 26 million people and leading to more than 0.85 million deaths as on 2nd September, 2020. Severity of SARS-CoV-2 infection increases in COVID-19 patients due to pre-existing health co-morbidities. This mini-review has focused on the three significant co-morbidities viz., heart disease, hypertension, and diabetes, which are posing high health concerns and increased mortality during this ongoing pandemic. The observed co-morbidities have been found to be associated with the increasing risk factors for SARS-CoV-2 infection and COVID-19 critical illness as well as to be associated positively with the worsening of the health condition of COVID-19 suffering individuals resulting in the high risk for mortality. SARS-CoV-2 enters host cell via angiotensin-converting enzyme 2 receptors. Regulation of crucial cardiovascular functions and metabolisms like blood pressure and sugar levels are being carried out by ACE2. This might be one of the reasons that contribute to the higher mortality in COVID-19 patients having co-morbidities. Clinical investigations have identified higher levels of creatinine, cardiac troponin I, alanine aminotransferase, NT-proBNP, creatine kinase, D-dimer, aspartate aminotransferase and lactate dehydrogenase in patients who have succumbed to death from COVID-19 as compared to recovered individuals. More investigations are required to identify the modes behind increased mortality in COVID-19 patients having co-morbidities of heart disease, hypertension, and diabetes. This will enable us to design and develop suitable therapeutic strategies for reducing the mortality. More attention and critical care need to be paid to such high risk patients suffering from co-morbidities during COVID-19 pandemic.

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Section: Covid-19 and Hypertensionmentioning

confidence: 99%

COVID-19 and the World with Co-Morbidities of Heart Disease, Hypertension and Diabetes

Anand¹,

Sangeetha²,

Fathah³

et al. 2020

J Pure Appl Microbiol

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“…30 Similar findings were reported in more recent metaanalyses. 31e37 Several studies have assessed the relationship between viral infections during pregnancy, such as those caused by HIV, 38,39 human papillomavirus, 40,41 cytomegalovirus, 42e44 hepatitis B virus, 45e49 herpes simplex virus, 50,51 Epstein-Barr virus, 52 and influenza A (H1N1), 53 and the risk for preeclampsia. The results of these studies have been conflicting.…”

Section: Introductionmentioning

confidence: 99%

SARS-CoV-2 infection during pregnancy and risk of preeclampsia: a systematic review and meta-analysis

Conde-Agudelo

Romero

2022

American Journal of Obstetrics and Gynecology

217

132

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OBJECTIVE To examine the relationship between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during pregnancy and the risk of preeclampsia. DATA SOURCES MEDLINE, EMBASE, POPLINE, CINAHL, LILACS, and WHO COVID-19, Chinese, and preprint databases (all from December 1, 2019 to May 31, 2021). Google Scholar, bibliographies, and conference proceedings were also searched. STUDY ELIGIBILITY CRITERIA Observational studies that assessed the association between SARS-CoV-2 infection during pregnancy and preeclampsia and that reported unadjusted and/or adjusted risk estimates and 95% confidence intervals (CIs) or data to calculate them. STUDY APPRAISAL AND SYNTHESIS METHODS The primary outcome was preeclampsia. Secondary outcomes included preeclampsia with severe features, preeclampsia without severe features, eclampsia, and the hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome. Two reviewers independently reviewed studies for inclusion, assessed their risk of bias, and extracted data. Pooled unadjusted and adjusted odds ratios (ORs) with 95% CIs, and 95% prediction interval were calculated. Heterogeneity was quantified with the І 2 statistic, where І 2 ≥30% indicated substantial heterogeneity. Subgroup and sensitivity analyses were performed for testing the robustness of the overall findings. RESULTS Twenty-eight studies that included 790,954 pregnant women, among which 15,524 were diagnosed with SARS-CoV-2 infection, met the inclusion criteria. The meta-analysis of unadjusted ORs showed that the odds of developing preeclampsia were significantly higher among pregnant women with SARS-CoV-2 infection than among those without SARS-CoV-2 infection (7.0% vs 4.8%; pooled OR 1.62, 95% CI 1.45-1.82; P <0.00001; І 2 =17%; 26 studies; 95% prediction interval of the OR, 1.28-2.05). The meta-analysis of adjusted ORs also showed that SARS-CoV-2 infection during pregnancy was associated with a significant increase in the odds of preeclampsia (pooled OR 1.58, 95% CI 1.39-1.80; P <0.0001; І 2 =0%; 11 studies). There was a statistically significant increase in the odds of preeclampsia with severe features (OR 1.76, 95% CI 1.18-2.63; І 2 =58%; 7 studies), eclampsia (OR 1.97, 95% CI 1.01-3.84; І 2 =0%, 3 studies), and HELLP syndrome (OR 2.10, 95% CI 1.48-2.97; 1 study) among pregnant women with SARS-CoV-2 infection, as compared to those without the infection. Overall, the direction and magnitude of the effect of SARS-CoV-2 infection during pregnancy on preeclampsia was consistent across most pre-specified subgroup and sensitivity analyses. Both asymptomatic and symptomatic SARS-CoV-2 infec...

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Chemical compositions and experimental and computational modeling activity of sea cucumber Holothuria parva ethanolic extract against herpes simplex virus type 1

Keshavarz

Shamsizadeh

Tavakoli

et al. 2021

Biomedicine & Pharmacotherapy

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Hsv Infection is Associated with Gestational Hypertension: Results from the Us National Inpatient Sample

Cited by 5 publications

References 19 publications

COVID-19 and the World with Co-Morbidities of Heart Disease, Hypertension and Diabetes

COVID-19 and the World with Co-Morbidities of Heart Disease, Hypertension and Diabetes

SARS-CoV-2 infection during pregnancy and risk of preeclampsia: a systematic review and meta-analysis

Chemical compositions and experimental and computational modeling activity of sea cucumber Holothuria parva ethanolic extract against herpes simplex virus type 1

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