Huangqi injection in the treatment of chronic heart failure

Abstract

Background:To evaluate the clinical effectiveness and safety of Huangqi injection (HI) in treating chronic heart failure (CHF) systematically.Methods:A literature search was conducted for retrieving randomized controlled trials (RCTs) on CHF treated by HI in the Cochrane Library, PubMed, Embase, China Biology Medicine disc, China National Knowledge Infrastructure Database, China Science and Technology Journal Database, Wanfang Database up to June, 6, 2017, and then the included RCTs were assessed by the Cochrane Risk of Bias Assessment Tool. The clinical total effective rate, left ventricular ejection fraction (LVEF), and others outcomes were analyzed by Review Manager 5.3 in random-effect model, the funnel plot were depicted as well. Meanwhile, the sensitivity analysis was carried out by STATA 12.0.Results:Sixteen RCTs involved 1864 patients were included. The result of HI group was more efficient in the clinical total effective rate (RR = 1.19, 95% confidence intervals (95% CI) [1.14–1.26], P < .00001). In addition, HI plus western medicine (WM) could improve LVEF (MD = 4.64, 95% CI [3.52–5.75], P < .00001), and others cardiac indexes. Meanwhile, a combination of HI and WM also can perfect 6 minutes walk test (6MWT). Three RCTs reported no serious adverse drug events/adverse drug reactions occurred.Conclusion:Compared with WM, a combination of HI and WM was more efficacious in improving the clinical total effective rate, and perfect patients’ condition, but more evidence-based medicine researches needed to support this study further.

Lycium barbarum polysaccharides restore adverse structural remodelling and cardiac contractile dysfunction induced by overexpression of microRNA‐1

“…Qili qiangxin capsule, a traditional Chinese medicine, has been approved in China to be used in combination therapy for chronic HF 34. Of note, several other traditional Chinese medicines such as Huangqi injection, Berberine, Shenfu decoction, Shengmai, Hawthorn, Curcumin, Resveratrol and Cannabinoids may have potential therapeutic use in HF as adjunctive treatments in clinical practice or animal models of human disease 31, 37, 38, 39, 40. All these findings manifest that herbal medicine products play more and more important role in modern medical therapy.…”

“…E, Comparison of length and variation of sarcomeres. **P < .01 vs WT, ## P < .01 vs Tg, data presented as mean AE SD (for variation), n = 80 from three hearts for each group ZHANG ET AL.| 4835 of those patients with many adverse side-effects such as producing poor compliance, promoting myocardial injury and remodelling, deteriorating cardiac function and even increasing the rate of sudden death caused by cardiac arrhythmia 1,31. Treatment of HF remains unsatisfactory as available treatments often fail to control the symptoms 32.…”

Chinese herbal injections for heart failure

“…To the best of our knowledge, this is the first NMA to comprehensively evaluate and compare the effect of different CHIs for heart failure, although a few studies have assessed the effect of the individual CHI. [ 6 , 21 , 22 ] We hope the results of this NMA will provide the clinical recommendation for patients with heart failure in Chinese medicine clinical practice or guideline.…”

“…[ 5 ] Although Chinese herbal injections (CHIs) are not the mainstream for the treatment of heart failure in the world, they are widely used as a complementary and alternative therapy for patients with heart failure in China due to its rapid action, high bioavailability, and no digestive tract absorption. [ 6 ]…”

The Effect and Mechanism of Chinese Herbal Formula Sini Tang in Heart Failure after Myocardial Infarction in Rats

“…Recently, the treatment of heart failure is mainly based on western medicine in clinical practice [ 3 – 6 ]. However, our traditional Chinese medicine (TCM) also plays an important role in the prevention and treatment of HF [ 7 – 13 ].…”