Huangqin Decoction ameliorates ulcerative colitis by regulating fatty acid metabolism to mediate macrophage polarization via activating FFAR4-AMPK-PPARα pathway

Li, Minyao; Wu, Yu-zhu; Qiu, Jian; Lei, Jun-xuan; Li, Muxia; Xu, Nan; Liu, Yuhong; Zhang, Jin; Su, Zi‐Ren; Lee, Simon Ming‐Yuen; Xiao, Zheng; Huang, Xiaoqi

doi:10.1016/j.jep.2023.116430

Cited by 16 publications

(8 citation statements)

References 38 publications

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“…However, this study did not clearly show that AMPK-PPARα changes occurred in macrophages. However, based on previous reports that AMPK, PPARα, and FAO are upregulated under the induction of IL-4+IL-13 ( 51 , 81 ), we speculated that a similar process would occur in macrophages. With IL-4 or MCSF induction, IRF4 is transcribed to promote FAO and OXPHOS by inducing glucose metabolism.…”

Section: The Regulation Of Macrophage Metabolismmentioning

confidence: 92%

“…PPARα is also involved in regulating macrophage metabolism. Li reported that in DSS-induced ulcerative colitis (UC), activation of AMPK-PPARα can promote β-oxidation, decrease de novo lipogenesis, and promote M2 polarization of macrophages ( 81 ) ( Figure 4B ). However, this study did not clearly show that AMPK-PPARα changes occurred in macrophages.…”

Section: The Regulation Of Macrophage Metabolismmentioning

confidence: 99%

“…According to the reports, Hippo can regulate cellular metabolism in tumors, hepatocytes, cardiomyocytes, and chondrocytes ( 93 – 97 ). And the AKT-mTOR, PPARγ, MEK/ERK, AMPK, NF-κB, HIF-1α, and Notch pathways play important roles in macrophage metabolism ( 64 – 69 , 77 , 80 , 81 ). Meanwhile, we also found that the Hippo pathway is in crosstalk with these regulatory pathways in macrophages or other cells ( 74 , 90 , 96 , 98 – 105 ).…”

Section: The Potential Relationship Of Hippo Pathway With the Regulat...mentioning

confidence: 99%

“…Deletion of YAP/TAZ in brown adipose tissue decreases the oxygen consumption rate and increases body fat content, suggesting that YAP/TAZ plays a role in lipid metabolism ( 97 ). They report that PPARγ and AMPK regulate M2 polarization by fatty acid metabolism ( 80 , 81 ). But no study directly suggests that Hippo is crosstalk with PPARγ and AMPK in macrophages.…”

Section: The Potential Relationship Of Hippo Pathway With the Regulat...mentioning

confidence: 99%

“…Therefore, it is necessary to explore the intrinsic metabolic mechanism in the process of macrophage polarization, especially in the state of diseases. Most studies on metabolic regulation have mainly focused on the PI3K-AKT-mTOR, PPARγ, AMPK, Notch, MEK/ERK, and NF-κB pathways ( 64 – 69 , 77 , 80 , 81 ). However, according to the literature, we found that the Hippo pathway can crosstalk with these metabolic regulatory pathways ( 74 , 90 , 96 , 98 – 105 ).…”

Section: Discuss: the Hippo Pathway And Metabolism In Macrophage Pola...mentioning

confidence: 99%

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The potential role of Hippo pathway regulates cellular metabolism via signaling crosstalk in disease-induced macrophage polarization

An,

Tan,

Yang

et al. 2024

Front. Immunol.

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Macrophages polarized into distinct phenotypes play vital roles in inflammatory diseases by clearing pathogens, promoting tissue repair, and maintaining homeostasis. Metabolism serves as a fundamental driver in regulating macrophage polarization, and understanding the interplay between macrophage metabolism and polarization is crucial for unraveling the mechanisms underlying inflammatory diseases. The intricate network of cellular signaling pathway plays a pivotal role in modulating macrophage metabolism, and growing evidence indicates that the Hippo pathway emerges as a central player in network of cellular metabolism signaling. This review aims to explore the impact of macrophage metabolism on polarization and summarize the cell signaling pathways that regulate macrophage metabolism in diseases. Specifically, we highlight the pivotal role of the Hippo pathway as a key regulator of cellular metabolism and reveal its potential relationship with metabolism in macrophage polarization.

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Section: The Regulation Of Macrophage Metabolismmentioning

confidence: 92%

Section: The Regulation Of Macrophage Metabolismmentioning

confidence: 99%

Section: The Potential Relationship Of Hippo Pathway With the Regulat...mentioning

confidence: 99%

Section: The Potential Relationship Of Hippo Pathway With the Regulat...mentioning

confidence: 99%

Section: Discuss: the Hippo Pathway And Metabolism In Macrophage Pola...mentioning

confidence: 99%

See 3 more Smart Citations

The potential role of Hippo pathway regulates cellular metabolism via signaling crosstalk in disease-induced macrophage polarization

An,

Tan,

Yang

et al. 2024

Front. Immunol.

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Xiaoyankangjun tablet alleviates dextran sulfate sodium-induced colitis in mice by regulating gut microbiota and JAK2/STAT3 pathway

Yang,

Huang,

Tan

et al. 2024

Nat. Prod. Bioprospect.

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Xiaoyankangjun tablet (XYKJP) is a traditional Chinese medicine formulation used to treat intestinal disorders in clinical practice. However, the specific therapeutic mechanism of action of XYKJP in colitis has not yet been elucidated. This study aimed to reveal the multifaceted mechanisms of action of XYKJP in treating colitis. The model established based on DSS-induced colitis in C57BL/6 mice was employed to estimate the effect of XYKJP on colitis, which was then followed by histological assessment, 16S rRNA sequencing, RT-qPCR, ELISA, and Western blot. XYKJP alleviated the symptoms of DSS-induced colitis mainly by reducing oxidative stress, inflammatory responses, and intestinal mucosal repair in colitis tissues. In addition, XYKJP regulated the intestinal flora by increasing the relative abundance of Akkermansia and Bifidobacterium and reducing the relative abundance of Coriobacteriaceae_UCG-002. Mechanistically, XYKJP increased the content of short-chain fatty acids (SCFAs) in the feces, particularly propanoic acid and butyric acid, activated their specific receptor GPR43/41, furthermore activated the Nrf2/HO-1 pathway, and suppressed the JAK2/STAT3 pathway. XYKJP significantly alleviated the symptoms of experimental colitis and functioned synergistically by regulating the intestinal flora, increasing the production of SCFAs, and activating their specific receptors, thereby repressing oxidative stress and inflammation. Graphical Abstract

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Protective effects of Amauroderma rugosum on dextran sulfate sodium-induced ulcerative colitis through the regulation of macrophage polarization and suppression of oxidative stress

Li,

Luo,

Shiu

et al. 2024

Biomedicine & Pharmacotherapy

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Huangqin Decoction ameliorates ulcerative colitis by regulating fatty acid metabolism to mediate macrophage polarization via activating FFAR4-AMPK-PPARα pathway

Cited by 16 publications

References 38 publications

The potential role of Hippo pathway regulates cellular metabolism via signaling crosstalk in disease-induced macrophage polarization

The potential role of Hippo pathway regulates cellular metabolism via signaling crosstalk in disease-induced macrophage polarization

Xiaoyankangjun tablet alleviates dextran sulfate sodium-induced colitis in mice by regulating gut microbiota and JAK2/STAT3 pathway

Protective effects of Amauroderma rugosum on dextran sulfate sodium-induced ulcerative colitis through the regulation of macrophage polarization and suppression of oxidative stress

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