Human Accelerated Regions regulate gene networks implicated in apical-to-basal neural progenitor fate transitions
Mark Alan Noble,
Yu Ji,
Kristina M. Yim
et al.
Abstract:The evolution of the human cerebral cortex involved modifications in the composition and proliferative potential of the neural stem cell (NSC) niche during brain development. Human Accelerated Regions (HARs) exhibit a significant excess of human-specific sequence changes and have been implicated in human brain evolution. Multiple studies support that HARs include neurodevelopmental enhancers with novel activities in humans, but their biological functions in NSCs have not been empirically assessed at scale. Her… Show more
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