2020
DOI: 10.1590/0074-02760190364
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Human acute Chagas disease: changes in factor VII, activated protein C and hepatic enzymes from patients of oral outbreaks in Pará State (Brazilian Amazon)

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Cited by 9 publications
(8 citation statements)
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“…(6,148) Another aspect to consider is that we are facing an acute infectious disease with chronic evolution of an inflammatory character in the acute phase, which suggests an alteration of coagulation factors, with thrombus and haemorrhage previously described. (143,149) In the pandemic scenario caused by Coronavirus disease 2019 (COVID-19), we warn of the possibility of coinfection at a time when there is no scientific evidence of the evolution of cases of coinfection of acute Chagas disease with other infectious diseases.…”
Section: Acute Chagas's Heart Disease: a New And Poorly Known Challengementioning
confidence: 99%
“…(6,148) Another aspect to consider is that we are facing an acute infectious disease with chronic evolution of an inflammatory character in the acute phase, which suggests an alteration of coagulation factors, with thrombus and haemorrhage previously described. (143,149) In the pandemic scenario caused by Coronavirus disease 2019 (COVID-19), we warn of the possibility of coinfection at a time when there is no scientific evidence of the evolution of cases of coinfection of acute Chagas disease with other infectious diseases.…”
Section: Acute Chagas's Heart Disease: a New And Poorly Known Challengementioning
confidence: 99%
“…Today we know that the liver is important in the clearance of blood trypomastigote forms (4) and that the disease carries additional risk in patients with non-alcoholic steatohepatitis (NASH), as it exacerbates hepatic injury (5). Accordingly, acutely infected patients have very high levels of hepatic transaminases and activated C protein, with lower levels of coagulation factor VII (6). Although the infection of hepatocytes is not high as in the case of macrophages or cardiomyocytes in vivo, these results indicate the profound impact of the infection on this cell type.…”
Section: Introductionmentioning
confidence: 99%
“…In acute chagasic patients, most likely infected by the oral route, levels of hepatic transaminases and activated C protein were increased, although with lower levels of coagulation factor VII [ 61 ]. All these proteins are synthesized by hepatocytes and indicate the profound impact of the infection on this cell type.…”
Section: Introductionmentioning
confidence: 99%