Human allogeneic CD2+ lymphocytes activate airway-derived epithelial cells to produce interleukin-6 and interleukin-8. Possible role for the epithelium in chronic allograft rejection

Borger, Pieter; Kauffman, Hf; Scholma, Janny; Timmerman, J. A. B.; Koeter, Gh

doi:10.1016/s1053-2498(01)00418-1

Cited by 12 publications

(6 citation statements)

References 22 publications

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“…Cell cultures. Human primary bronchial epithelial cells were collected and cultured by the methods described by Borger et al (8). For the experiments described, these cells were used at 80 -90% confluency in passage 2.…”

Section: Methodsmentioning

confidence: 99%

Cigarette smoke-induced blockade of the mitochondrial respiratory chain switches lung epithelial cell apoptosis into necrosis

Toorn

Slebos

Bruin³

et al. 2007

American Journal of Physiology-Lung Cellular and Molecular Phys

134

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Increased lung cell apoptosis and necrosis occur in patients with chronic obstructive pulmonary disease (COPD). Mitochondria are crucially involved in the regulation of these cell death processes. Cigarette smoke is the main risk factor for development of COPD. We hypothesized that cigarette smoke disturbs mitochondrial function, thereby decreasing the capacity of mitochondria for ATP synthesis, leading to cellular necrosis. This hypothesis was tested in both human bronchial epithelial cells and isolated mitochondria. Cigarette smoke extract exposure resulted in a dose-dependent inhibition of complex I and II activities. This inhibition was accompanied by decreases in mitochondrial membrane potential, mitochondrial oxygen consumption, and production of ATP. Cigarette smoke extract abolished the staurosporin-induced caspase-3 and -7 activities and induced a switch from epithelial cell apoptosis into necrosis. Cigarette smoke induced mitochondrial dysfunction, with compounds of cigarette smoke acting as blocking agents of the mitochondrial respiratory chain; loss of ATP generation leading to cellular necrosis instead of apoptosis is a new pathophysiological concept of COPD development.

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Section: Methodsmentioning

confidence: 99%

Cigarette smoke-induced blockade of the mitochondrial respiratory chain switches lung epithelial cell apoptosis into necrosis

Toorn

Slebos

Bruin³

et al. 2007

American Journal of Physiology-Lung Cellular and Molecular Phys

134

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“…Recently we showed that the interaction of these alloreactive host lymphocytes with airway epithelial cells of the donor resulted in abundant cytokine production of the epithelial cells. 35 Once BO is present, IL-8 production is still enhanced and this epithelial-derived proinflammatory cytokine acts as a neutrophilic chemoattractant, as shown by the large number of neutrophils present in BO patients. 33,36 Our study shows a possible diagnostic role for cellular and soluble analysis of BALF, because it may detect BO and AR after LTx.…”

Section: Balf In Armentioning

confidence: 99%

Bronchoalveolar lavage fluid characteristics in acute and chronic lung transplant rejection

Slebos¹,

Postma²,

Koëter³

et al. 2004

The Journal of Heart and Lung Transplantation

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“…Airway virus infection, ischemiaperfusion injury, human leukocyte antigen mismatching, and lymphocyte-epithelial interactions also are implicated. 4,19,20,[22][23][24] Unlike acute rejection, which reverses with increased immunosuppression, chronic OB/BOS responds poorly.…”

mentioning

confidence: 99%

Transcript Signatures of Lymphocytic Bronchitis in Lung Allograft Biopsy Specimens

Golden

Dolganov³

et al. 2005

The Journal of Heart and Lung Transplantation

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Human allogeneic CD2+ lymphocytes activate airway-derived epithelial cells to produce interleukin-6 and interleukin-8. Possible role for the epithelium in chronic allograft rejection

Cited by 12 publications

References 22 publications

Cigarette smoke-induced blockade of the mitochondrial respiratory chain switches lung epithelial cell apoptosis into necrosis

Cigarette smoke-induced blockade of the mitochondrial respiratory chain switches lung epithelial cell apoptosis into necrosis

Bronchoalveolar lavage fluid characteristics in acute and chronic lung transplant rejection

Transcript Signatures of Lymphocytic Bronchitis in Lung Allograft Biopsy Specimens

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