Human Amniotic Membrane Promotes Antimicrobial Microenvironment in a Device-Related Infection

Abstract

Hospital inquired post-operative infections are a leading cause of morbidity and mortality in patients receiving left ventricular assist devices. We present the case of a patient who acquired Candida albicans and Staphylococci infections following left ventricular assist device implantation. Use of standard antibiotics caused the infection to worsen, thus an amniotic membrane patch was used as a last-resort treatment. Within 6 weeks of the amniotic membrane patch treatment, the infection resolved, the wound appeared exceptionally clean upon inspection, and granulation tissue was present. After the infection resolved, a successful latissimusdorsi tissue flap procedure was completed and the patient made a full recovery.

Antimicrobial Effect of the Amniotic Membrane Isolated and Associated with Photodynamic Therapy

“…Thus, AM was used as a last resort treatment, and within 6 weeks, the wound was clear and the infection appeared to be resolved. After the resolution of the infection, a wound site grafting procedure with latissimus dorsi muscle tissue was performed, and the patient made a full recovery [ 11 ].…”