Human amniotic mesenchymal stromal cell transplantation improves endometrial regeneration in rodent models of intrauterine adhesions

Gan, Lu; Duan, Hua; Xu, Qian; Tang, Yinshan; Li, Jin-Jiao; Sun, Fuqing; Sha, Wang

doi:10.1016/j.jcyt.2017.02.003

Cited by 105 publications

(83 citation statements)

References 39 publications

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“…Stem cell therapy has been applied to treat infertility, especially Asherman’s syndrome [233], which is characterized by endometrium adhesion and fibrosis due to tuberculosis infection or following hysteroscopic procedures such as dilation and curettage; such patients present with absent menstruation and infertility. The objective of MSC transplantation therapy is to reduce the degree of inflammation after adhesiolysis and promote endometrial regeneration [234]. Autologous in utero BM stem cell transplantation facilitated IVF in a case report of a woman with severe endometrial adhesion following dilation and curettage [235].…”

Section: Cell-based Therapy For Endometriosis Treatmentmentioning

confidence: 99%

Chronic Niche Inflammation in Endometriosis-Associated Infertility: Current Understanding and Future Therapeutic Strategies

Lin

Chen

Chang

et al. 2018

IJMS

140

104

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Endometriosis is an estrogen-dependent inflammatory disease that affects up to 10% of women of reproductive age and accounts for up to 50% of female infertility cases. It has been highly associated with poorer outcomes of assisted reproductive technology (ART), including decreased oocyte retrieval, lower implantation, and pregnancy rates. A better understanding of the pathogenesis of endometriosis-associated infertility is crucial for improving infertility treatment outcomes. Current theories regarding how endometriosis reduces fertility include anatomical distortion, ovulatory dysfunction, and niche inflammation-associated peritoneal or implantation defects. This review will survey the latest evidence on the role of inflammatory niche in the peritoneal cavity, ovaries, and uterus of endometriosis patients. Nonhormone treatment strategies that target these inflammation processes are also included. Furthermore, mesenchymal stem cell-based therapies are highlighted for potential endometriosis treatment because of their immunomodulatory effects and tropism toward inflamed lesion foci. Potential applications of stem cell therapy in treatment of endometriosis-associated infertility in particular for safety and efficacy are discussed.

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Section: Cell-based Therapy For Endometriosis Treatmentmentioning

confidence: 99%

Chronic Niche Inflammation in Endometriosis-Associated Infertility: Current Understanding and Future Therapeutic Strategies

Lin

Chen

Chang

et al. 2018

IJMS

140

104

View full text Add to dashboard Cite

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“…Biopsy of the residue of amniotic membrane that was used after hysteroscopic adhesiolysis detected the presence of mesenchymal stem cells 23 Gan et al 24 transplanted human amniotic mesenchymal cells into a rodent model of intrauterine adhesion and found that they increased the thickness of endometrium through both regeneration of endometrial epithelial cells and by increasing glandular volume.…”

Section: Discussionmentioning

confidence: 99%

“…By contrast, the expression of proinflammatory factors was downregulated. 24 Tseng et al 25 reported that the amniotic membrane could prevent the formation of fibrous scar tissue by downregulating the expression of transforming growth factor.…”

Section: Discussionmentioning

confidence: 99%

Meta‐analysis of the use of amniotic membrane to prevent recurrence of intrauterine adhesion after hysteroscopic adhesiolysis

Zheng

Zhu

Liu

et al. 2018

Intl J Gynecology & Obste

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“…Meanwhile, various techniques for adhesiolysis and prevention of scar formation have also been applied in the clinic [9]. Indeed, the hysteroscopy with lysis of the scar tissue shows its huge advantage of restoring normal uterine function in many cases.…”

Section: Introductionmentioning

confidence: 99%

Decreased CXCL5 expression associated with intrauterine adhesions in a rat model and human endometrial tissues

Sun

Fang

Gao

et al. 2020

Preprint

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Background Intrauterine adhesion (IUA) is a consequence of endometrium damage, leading to infertility, recurrent miscarriage, and various complications of pregnancy. IUA usually occurs after an infection or injury-related inflammation of the endometrium. CXCL5, a member of chemokines, is associated with the remodeling of connective tissues, but its roles in the formation of IUA remain uncertain. This study aims to investigate the expression and effect of CXCL5 in the development of IUA. Results CXCL5 protein level in the endometrium of IUA rat is significantly decreased compared with that in normal and sham-operated endometria of rats (P < 0.001). Furthermore, real-time PCR and western blotting assays also show that the CXCL5 expression in endometrial tissues from IUA patients is much lower than that in normal endometrium (P < 0.01), which is consistent with the results based on the rat model. CXCL5 significantly up-regulates MMP9 expression and slightly up-regulates p65 expression in human endometrial cells after CXCL5 overexpression. Conclusions These results show that CXCL5 plays an important role in the inhibition of IUA formation after injury by modulating MMP9 expression and therefore has a protective effect of CXCL5 in the adhesion formation of IUA. These findings provide valuable information for evaluating prognosis and guiding therapy of intrauterine adhesions.

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Human amniotic mesenchymal stromal cell transplantation improves endometrial regeneration in rodent models of intrauterine adhesions

Cited by 105 publications

References 39 publications

Chronic Niche Inflammation in Endometriosis-Associated Infertility: Current Understanding and Future Therapeutic Strategies

Chronic Niche Inflammation in Endometriosis-Associated Infertility: Current Understanding and Future Therapeutic Strategies

Meta‐analysis of the use of amniotic membrane to prevent recurrence of intrauterine adhesion after hysteroscopic adhesiolysis

Decreased CXCL5 expression associated with intrauterine adhesions in a rat model and human endometrial tissues

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