Human and environmental health challenges for the next decade (2010–2020)

Bonnefoi, Marc S; Belanger, Scott E.; Devlin, Dennis J.; Doerrer, Nancy G.; Embry, Michelle R.; Fukushima, Shoji; Harpur, Ernest S.; Hines, Ronald N.; Holsapple, Michael P.; Kim, James H.; Macdonald, J. S.; O’Lone, Raegan; Pettit, Syril; Stevens, James; Takei, Ayako S; Tinkle, Sally S.; Laan, Jan Willem van der

doi:10.3109/10408444.2010.506640

Cited by 16 publications

(3 citation statements)

References 14 publications

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“…Whenever engineered nanomaterials are within the reach of the skin, they penetrate the outer protective layers and reach the epidermis. A study by Tinkle and others [23], have shown latex particle smaller than 1 micrometer can penetrate the skin's outer layer. People using skin preparations such as cosmetics and sun-screen contain titanium dioxide nanoparticles.…”

Section: The Potential Risk Of Nanotechnologymentioning

confidence: 97%

An overview of nanotechnology and its potential risk

Afolalu,

Kayode,

Monye

et al. 2023

E3S Web Conf.

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Nanotechnology has vastly been investigated due to its potential to increase the field of biotechnology and medical advances. Though, regulatory agencies such as FDA oversee the emerging field of nanotechnology through legislative arrangements. Mechanistic knowledge of nanostructure material behavior in the human body, animals, and environment is significant. This paper investigated the role of nanotechnology and its relevant development and improvement in science. Likewise, it exposes or brings to the limelight the threats associated with nanoparticles and their application in various fields of study, most especially the alarming effects on humans, animals, and the environment when inhaled or consumed in the form of nano-medicine, food, etc

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Section: The Potential Risk Of Nanotechnologymentioning

confidence: 97%

An overview of nanotechnology and its potential risk

Afolalu,

Kayode,

Monye

et al. 2023

E3S Web Conf.

View full text Add to dashboard Cite

show abstract

“…The novel approaches for risk assessment of nanomaterials using computational tools, like quantitative structure activity relationships (QSARs), are discussed in several publications [25][26][27][28][29][30][31][32]. Thus, reliable QSAR models can offer a time-effective and cost-effective measure of chemicals' properties in the absence of new experimental data.…”

Section: Introductionmentioning

confidence: 99%

A Comprehensive Cheminformatics Analysis of Structural Features Affecting the Binding Activity of Fullerene Derivatives

et al. 2020

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Nanostructures like fullerene derivatives (FDs) belong to a new family of nano-sized organic compounds. Fullerenes have found a widespread application in material science, pharmaceutical, biomedical, and medical fields. This fact caused the importance of the study of pharmacological as well as toxicological properties of this relatively new family of chemicals. In this work, a large set of 169 FDs and their binding activity to 1117 disease-related proteins was investigated. The structure-based descriptors widely used in drug design (so-called drug-like descriptors) were applied to understand cheminformatics characteristics related to the binding activity of fullerene nanostructures. Investigation of applied descriptors demonstrated that polarizability, topological diameter, and rotatable bonds play the most significant role in the binding activity of FDs. Various cheminformatics methods, including the counter propagation artificial neural network (CPANN) and Kohonen network as visualization tool, were applied. The results of this study can be applied to compose the priority list for testing in risk assessment related to the toxicological properties of FDs. The pharmacologist can filter the data from the heat map to view all possible side effects for selected FDs.

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“…There is a wide variation in the animal and human response to ubiquitous environmental pollutants 22 . Interestingly, we previously observed an increase in lung cancer incidence in THS-treated A/J mice 11,23 but not in similarly treated C57BL/6 mice (ref 17, and Martins-Green, personal communication).…”

mentioning

confidence: 99%

Genetic background influences the effect of thirdhand smoke exposure on anxiety and memory in Collaborative Cross mice

Wang

Schick

et al. 2021

Sci Rep

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Growing evidence indicates that thirdhand smoke (THS) exposure induces many adverse health effects. However, it is unclear how THS exposure affects behavior and how host genetic background modulates phenotypic changes. Here we used the Collaborative Cross (CC) mouse population-based model to assess behavioral alterations immediately after THS exposure from 4 to 9 weeks of age. We first measured anxiety-like behavior in six strains using light/dark box combined with a custom multivariate mouse tracking system. We developed an anxiety risk scoring system based on anxiety-related traits and then evaluated the THS impact on them. THS exposure significantly decreased anxiety risk in CC019 (P = 0.002) and CC051 (P = 0.009), but increased anxiety risk in CC036 (P < 0.001), while the other three strains did not show significant changes in anxiety-related traits. Such differences were driven by female mice for the six measures of anxiety-like behavior. Memory potential was measured in the same cohort of mice using the passive avoidance assay. Both THS-exposed male and female CC019 mice displayed significant memory loss compared to controls while no significant changes were found in the other five strains. This study provides strong evidence that THS exposure leads to strain-dependent changes in anxiety-like behavior and memory, suggesting that host genetic variations play a critical role in individual susceptibility to THS-induced effects.

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Human and environmental health challenges for the next decade (2010–2020)

Cited by 16 publications

References 14 publications

An overview of nanotechnology and its potential risk

An overview of nanotechnology and its potential risk

A Comprehensive Cheminformatics Analysis of Structural Features Affecting the Binding Activity of Fullerene Derivatives

Genetic background influences the effect of thirdhand smoke exposure on anxiety and memory in Collaborative Cross mice

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