Human Atrial Natriuretic Peptide Attenuates Renal Ischemia-Reperfusion Injury

Koga, Hironori; Hagiwara, Satoshi; Kusaka, Junya; Matsumoto, Shigekiyo; Nishida, Taichi; Yokoi, Isao; Noguchi, Takayuki

doi:10.1016/j.jss.2010.10.011

Cited by 20 publications

(11 citation statements)

References 25 publications

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“…ANP has been known to protect renal IR injury (Ambwani et al, 2009;Koga et al, 2012;Nakamoto et al, 1987). ANP has natriuretic, diuretic, vasorelaxant, antihypertensive, and anti-renin-angiotensinaldosterone properties.…”

Section: Discussionmentioning

confidence: 99%

C-type natriuretic peptide ameliorates ischemia/reperfusion-induced acute kidney injury by inhibiting apoptosis and oxidative stress in rats

Xiunan

Zhang

et al. 2014

Life Sciences

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Section: Discussionmentioning

confidence: 99%

C-type natriuretic peptide ameliorates ischemia/reperfusion-induced acute kidney injury by inhibiting apoptosis and oxidative stress in rats

Xiunan

Zhang

et al. 2014

Life Sciences

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“…BUN and creatinine levels measured to assess the renal function were significantly higher in the I/R group compared to the control group, while they were significantly decreased in the EPC-K1-treated group. Koga et al (15) reported that human atrial natriuretic peptide (hANP) was effective in the treatment of a number of types of I/R injuries and that the renal protective effect of hANP could be associated with its antioxidant properties. In this particular study on rats, serum BUN and creatinine levels were demonstrated to be increased in the I/R group, but the increment was significantly inhibited in the hANP-treated group, and renal tissue damage was attenuated with hANP administration (15).…”

Section: Discussionmentioning

confidence: 99%

Effects of apelin and leptin on renal functions following renal ischemia/reperfusion: An experimental study

Sagiroglu

Torun

Yağcı

et al. 2012

Experimental and Therapeutic Medicine

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The present study aimed to investigate the effects of apelin and leptin on renal functions following renal ischemia/reperfusion (I/R). A total of 32 rats were divided into four groups. The control group was not induced with ischemia, but was administered normal saline intraperitoneally. Normal saline, apelin and leptin were administered intraperitoneally to the I/R, ischemia/reperfusion and apelin (I/R+A) and ischemia/reperfusion and leptin (I/R+L) groups, in turn for three days prior to the surgical procedure. Blood and urine samples were obtained after 24 h of reperfusion, and scintigraphic examination was performed. Renal damage was evaluated histopathologically. Urea levels of the I/R+L and I/R+A groups were comparable, but were higher compared to that of the control group. The I/R group had the highest urea levels (control, 27±2; I/R, 120±15; I/R+A, 75±10; I/R+L, 80±11; p<0.001). Creatinine levels were higher in all three ischemic groups compared to the control group. Glomerular filtration rate values of the I/R+A and I/R+L groups were not significantly, but numerically higher compared to that of the I/R group. No pathological damage was observed in any of the animals in the control group. In the I/R group, two animals had moderate and six had severe renal damage, while three had moderate and one had severe renal damage in the I/R+L group. In the I/R+A group, moderate renal damage was found in one animal, while none had severe renal damage. This study demonstrates the functional and histopathological protective effects of leptin and apelin against renal I/R injury.

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“…The mechanism of the protective effect of ANP is related to reduction in oxidative stress, inhibition of inflammation and inflammatory cell infiltration, and protection of endothelial function (Dodd-o et al, 2008;Aoyama et al, 2009;Yamada et al, 2013). A recent study on renal IRI reported that ANP also plays a protective role in ischemic renal injury (Koga et al, 2012). It has been established that the physiological effect of BNP is somewhat similar to that of ANP.…”

Section: Introductionmentioning

confidence: 99%

Protective effect of lyophilized recombinant human brain natriuretic peptide on renal ischemia/reperfusion injury in mice

et al. 2015

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ABSTRACT. Brain natriuretic peptide (BNP) has a protective effect on acute injury of the heart, brain, and lung. However, its role in acute kidney injury (AKI) remains unclear. The aim of this study was to investigate the effect of lyophilized recombinant human BNP (lrh-BNP) on AKI and the underlying molecular mechanisms. An experimental model for AKI was established using an ischemia/reperfusion (I/R) procedure. Healthy adult BALB/c mice were randomized to the sham, I/R, and lrh-BNP-treated post-I/R (BNP + I/R) groups. Post-operatively, the BNP + I/R group was subcutaneously injected with lrh-BNP (0.03 µg·kg -1 ·min -1 ), whereas the other groups received saline at the same dose. Serum creatinine (Scr) and blood urea nitrogen levels were examined; tissue staining was performed to evaluate the degree of I/R injury (IRI). Ki67 positive staining of renal tubular epithelial cells was observed using immunofluorescence confocal laser scanning to assess the effect of BNP on cell proliferation after IRI. Inflammatory factor expression levels were detected to evaluate the effect of BNP on renal inflammation. Compared with the sham group, the I/R 13301 Effect of BNP on renal IRI ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (4): 13300-13311 (2015) group showed increased Scr levels, severe tubular injury of the renal outer medulla, increased Kim-1 mRNA expression, an increased number of infiltrative macrophages in the renal interstitium, and increased TNF-α, IL-1β, IL-6, MCP-1, and HIF-1α mRNA expression. BNP delivery significantly reduced all pathological changes in the I/R group. The protective role of BNP in murine renal IRI may be associated with its inhibition of renal interstitial inflammation and hypoxia and its promotion of renal tubule repair.

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Human Atrial Natriuretic Peptide Attenuates Renal Ischemia-Reperfusion Injury

Cited by 20 publications

References 25 publications

C-type natriuretic peptide ameliorates ischemia/reperfusion-induced acute kidney injury by inhibiting apoptosis and oxidative stress in rats

C-type natriuretic peptide ameliorates ischemia/reperfusion-induced acute kidney injury by inhibiting apoptosis and oxidative stress in rats

Effects of apelin and leptin on renal functions following renal ischemia/reperfusion: An experimental study

Protective effect of lyophilized recombinant human brain natriuretic peptide on renal ischemia/reperfusion injury in mice

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