Human behavioral toxicology. Central nervous effects of low-dose exposure to neurotoxic substances in the work environment.

Iregren, Anders; Gamberale, Francesco

doi:10.5271/sjweh.1826

Cited by 34 publications

(4 citation statements)

References 15 publications

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“…Letz's subsequent adaptation of the battery (the NES II) became the dominant testing system in 1990s 12,13) . Iregren et al 14) developed Swedish performance evaluation system (SPES), which was used for screening test for neurobehavioral disturbances of some neurotoxins [15][16][17][18] . Recently, the behavioral assessment and research system (BARS) was used for the detection of neurotoxicity in non-mainstream human populations specifically people with limited education or literacy [19][20][21] .…”

Section: Introductionmentioning

confidence: 99%

Neurobehavioral Changes of Shipyard Painters Exposed to Mixed Organic Solvents

et al. 2005

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Abstracts: This study was conducted to evaluate neurobehavioral changes arising from occupational exposure to organic solvents among shipyard painters and to establish whether a dose-effect relation existed where there was any observed impairment of neurobehavioral performance by running the test of Simple Reaction Time (SRT), Symbol Digit Substitution (SD), and Finger Tapping Speed (FT) with a computer-assisted neurobehavioral test battery. The study group consisted of 180 shipyard painters and 60 reference workers. The workers answered a self-administered questionnaire on occupational, medical history, and demographic characteristics including age, work duration, education level, and quantity and frequency of alcohol and smoking, and performed three psychometric tests on the Korean Computerized Neurobehavioral tests. To estimate cumulative exposure level, samples of ambient air on 61 painters were analyzed using a gas chromatograph. Shipyard painters and the reference group showed significant differences in the results of test of SD, FT of dominant hand, and FT of non-dominant hand. The test results of SD of shipyard painters also showed significant difference by duration of work. This suggests that occupational exposure of organic solvent could induce neurobehavioral changes in the shipyard painters. Therefore an objective neurobehavioral test is recommended on evaluating neurobehavioral performance of longterm solvent-exposed shipyard workers.

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Section: Introductionmentioning

confidence: 99%

Neurobehavioral Changes of Shipyard Painters Exposed to Mixed Organic Solvents

et al. 2005

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“…Most experiments have been performed to investigate effects from exposure to at a few stable concentrations of a single compound (37,38). Still, in the work environment, exposure to a single solvent is the exception, and stable exposure levels are likewise seldom found in industry.…”

Section: Quantification Ofexposurementioning

confidence: 99%

Behavioral methods and organic solvents: questions and consequences.

Iregren¹

1996

Environ Health Perspect

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This paper reviews some illustrative examples of studies of human neurobehavioral effects from experimental as well as long-term occupational organic-solvent exposure. My objective is to present a selection of neurobehavioral solvent studies with the educational aim that we may hopefully learn from the early experiences of others. Some of the methodological problems encountered in these studies are discussed, as well as some reasons for the relative success of the work performed by certain Scandinavian research teams. Environ Health Perspect 104 (Suppl 2): 361-366 (1996)

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“…At lower levels of exposure, subtle changes in behavioral functioning can occur, particularly those related to information processing and psychomotor function. 4-7 OELs that are based on acute CNS depression usually provide an adequate measure of protection for other, more profound manifestations of CNS effects as well as other nervous system effects. 8…”

mentioning

confidence: 99%

“…At lower levels of exposure, subtle changes in behavioral functioning can occur, particularly those related to information processing and psychomotor function. [4][5][6][7] OELs that are based on acute CNS depression usually provide an adequate measure of protection for other, more profound manifestations of CNS effects as well as other nervous system effects. 8 Over the years, there has been significant progress in the development of methods for evaluating the effects of hydrocarbon solvents on the animal and human nervous system.…”

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confidence: 99%

Neurobehavioral Effects of Cyclohexane in Rat and Human

et al. 2009

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The neurobehavioral effects of inhaled cyclohexane in rats and humans are investigated to define relationships between internal doses and acute central nervous system effects. Rats are exposed for 3 consecutive days at target concentrations of 0, 1.4, 8, and 28 g/m(3), 8 h/d. Measurements include standardized observational measures, spontaneous motor activity assessments, and learned visual discrimination performance. Cyclohexane concentrations in blood and brain are measured to assess internal exposure. Human volunteers are exposed for 4 hours to 86 or 860 mg/m(3) in 2 test sessions. Neurobehavioral effects are measured using a computerized neurobehavioral test battery. In rats, there are slight reductions in psychomotor speed in the high-exposure group but minimal central nervous system effects. In humans, there are no significant treatment-related effects at the levels tested.

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Human behavioral toxicology. Central nervous effects of low-dose exposure to neurotoxic substances in the work environment.

Cited by 34 publications

References 15 publications

Neurobehavioral Changes of Shipyard Painters Exposed to Mixed Organic Solvents

Neurobehavioral Changes of Shipyard Painters Exposed to Mixed Organic Solvents

Behavioral methods and organic solvents: questions and consequences.

Neurobehavioral Effects of Cyclohexane in Rat and Human

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