Human biomonitoring and policy making

Lagerqvist, Anne; Birgisdóttir, Bryndís Eva; Halldórsson, Thorhallur I.; Thomsen, Catherine; Darnerud, Per Ola; Kotova, Natalia

doi:10.6027/tn2015-571

Cited by 3 publications

(3 citation statements)

References 18 publications

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“…The frequency of micronuclei (MN), measured in the very youngest erythrocytes, represents a sensitive biomarker of genotoxic effect and could also often be interpreted as a measure of the total genotoxic exposure. Therefore, it is of great value to be able to use these sensitive biomarkers for human biomonitoring in the same blood samples, in an effort to monitor and characterize the body burden of toxic chemical compounds or their metabolites, for instance, in children …”

Section: Introductionmentioning

confidence: 99%

Adductomic Screening of Hemoglobin Adducts and Monitoring of Micronuclei in School-Age Children

Carlsson

Aasa

Kotova

et al. 2017

Chem. Res. Toxicol.

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Electrophilic compounds/metabolites present in humans, originating from endogenous processes or exogenous exposure, pose a risk to health effects through their reactions with nucleophilic sites in proteins and DNA, forming adducts. Adductomic approaches are developed to screen for adducts to biomacromolecules in vivo by mass spectrometry (MS), with the aim to detect adducts corresponding to unknown exposures from electrophiles. In the present study, adductomic screening was performed using blood samples from healthy children about 12 years old (n = 51). The frequencies of micronuclei (MN) in erythrocytes in peripheral blood were monitored as a measure of genotoxic effect/genotoxic exposure. The applied adductomic approach has been reported earlier by us and is based on analysis of N-terminal valine adducts in hemoglobin (Hb) by liquid chromatography tandem mass spectrometry (LC-MS/MS). High resolution MS was introduced for refined screening of previously unknown N-terminal Hb adducts. Measured adduct levels were compared with MN frequencies using multivariate data analysis. In the 51 individuals, a total of 24 adducts (whereof 12 were previously identified) were observed and their levels quantified. Relatively large interindividual variations in adduct levels were observed. The data analysis (with partial least-squares regression) showed that as much as 60% of the MN variation could be explained by the adduct levels. This study, for the first time, applies the combination of these sensitive methods to measure the internal dose of potentially genotoxic chemicals and genotoxic effects, respectively. The results indicate that this is a valuable approach for the characterization of exposure to chemical risk factors for the genotoxic effects present in individuals of the general population.

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Section: Introductionmentioning

confidence: 99%

Adductomic Screening of Hemoglobin Adducts and Monitoring of Micronuclei in School-Age Children

Carlsson

Aasa

Kotova

et al. 2017

Chem. Res. Toxicol.

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“…In May 2014 a seminar with the topic "Human biomonitoring as a tool in policy making towards consumer safety" was held in Stockholm. The conclusion was that HBM provides a powerful tool in policy making both within food safety and nutrition (Lagerqvist et al, 2015). Traditionally authorities in the Nordic countries have not been using HBM in this work and the seminar was also a start of collaboration and harmonization.…”

Section: Discussionmentioning

confidence: 99%

“…In May 2014 a seminar on the topic of "Human biomonitoring as a tool in policy making towards consumer safety" (Lagerqvist et al, 2015) was organized by the Swedish National Food Agency (NFA) in collaboration with the Norwegian Food Safety Authority, the Norwegian Institute of Public Health, the Unit for Nutrition Research at the University of Iceland, and Karolinska Institute, Sweden. The seminar was directed towards professionals involved in HBM programs, both at universities and authorities.…”

Section: Introductionmentioning

confidence: 99%

Human Biomonitoring at Food Authorities

Mattisson¹,

Abramsson²,

Eneroth³

et al. 2018

TemaNord

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Human biomonitoring (HBM) provides a powerful tool in risk and benefit assessment and policy making both for food safety and nutrition. HBM integrates exposure from all sources, can be used to demonstrate trends, to identify vulnerable groups and emerging risks. Limitations are e.g. that HBM does not provide any information on the source of exposure or how long a chemical has been in the body. There is a need to develop HBM to increase its usefulness in policy making. This report maps HBM studies performed at or initiated by food safety authorities in the Nordic countries and discuss problems and options for further work. Traditionally authorities in the Nordic countries have not been using HBM in their work. The report shows that only few studies have been performed and it differs among the countries. There might be several reasons for this e.g. sampling blood and urine is demanding, there are ethical and privacy issues and analytical costs are high. Also, studies performed at other institutions can be used by the national authorities but such studies are not included in this report. One way forward is cooperation-with researchers and between authorities in different countries. Furthermore, food safety authorities have special responsibilities in cases of emergencies and disasters. In these cases HBM provides a good tool for exposure measurement but cooperation and infrastructure for sampling and handling of samples must be established beforehand.

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