Human body models for validation studies of deep hyperthermia

Toseroni, I.; Ciampa, S.; Cavagnaro, Marta

doi:10.1002/mmce.21207

Cited by 2 publications

(1 citation statement)

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“…Fiber optic sensors for temperature monitoring have been developed to monitor the temperatures in several points without a significant increase of invasiveness . With the development of medical imaging technology, the temperatures in MWA can be noninvasively estimated from magnetic resonance imaging, computed tomography, ultrasound imaging, and infrared‐thermography, although these modalities have their own drawbacks . Therefore, it may be possible to measure the temperatures at a certain point simply and noninvasively in the future.…”

Section: Discussionmentioning

confidence: 99%

2450-MHz microwave ablation temperature simulation using temperature-dependence feedback of characteristic parameters

Gao

Wang

et al. 2018

Int J RF Microw Comput Aided Eng

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Temperature predictions of microwave ablation (MWA) are currently restricted by the specific temperature-dependent data of tissue characteristic parameters. To address this issue, a new parameter feedback method based on temperature simulations and single-thermometry measurements was presented. Experimental data of 2450-MHz microwave antenna was obtained from ex vivo porcine livers. A temperature distribution model was constructed, and the contributions of characteristic parameters were acquired by the sensitivity analysis method. Subsequently, parameter feedbacks were conducted based on a minimization of the errors between numerical data and single-thermometry measurements. The temperature distribution model was then optimized using the feedback parameters. Finally, temperature measurements were compared with simulation data to validate the accuracy of the model. According to the temperature distribution model with parameter feedback, the averages of maximum error, average error, as well as SD between the simulation temperatures and the measurements were 2.952, 1.323, and 0.852 C, respectively. The simulated and measured temperature changes were generally in good agreement. The proposed method can be useful in MWA temperature simulations to improve temperature prediction accuracy. K E Y W O R D S characteristic parameters, microwave ablation, parameter feedback, temperature distribution simulation 1 | INTRODUCTIONMicrowave ablation (MWA) has become an effective technique to treat liver tumors. 1 A microwave (MW) antenna is percutaneously inserted into the tumor to induce coagulation necrosis, thereby killing tumor cells in situ. 2 In the clinical MWA, 915-and 2450-MHz MWAs are usually used 3-5 to obtain desired thermal coagulation by constant powers such as 40, 50, and 60 W. Compared with surgical resections, MWA has fewer complications and minimally invasive advantages. [6][7][8][9] Many studies show that complete coagulation can occur instantly at least 55-60 C. [10][11][12] In the treatment of liver tumors, the zone with the temperature higher than 54 C is considered as thermal coagulation zone. 13 Although MWA has promising application prospects, temperature distributions are still difficult to predict and monitor precisely. Therefore, how to control ablation temperatures and coagulation zones has become a well-recognized challenge. 14 At present, a wide variety of simulation methods based on electromagnetic and bio-heat transfer equations have been proposed to predict complete temperature distributions induced by MW antenna. [15][16][17] The advantages of temperature simulations over the sparse data from the invasive thermometry are the possibility of generating three-dimensional (3D) temperature distributions. 18 However, the simulation precisions of temperature distributions have still not met the clinical requirements due to several factors such as interindividual differences, varying tissue characteristics and complicated bio-heat transfer mechanism. 19 Conventionally, the changes in characteristic para...

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