Human bone marrow-derived and umbilical cord-derived mesenchymal stem cells for alleviating neuropathic pain in a spinal cord injury model

Yousefifard, Mahmoud; Nasirinezhad, Farinaz; Manaheji, Homa; Janzadeh, Atousa; Hosseini, Mostafa; Keshavarz, Mansoor

doi:10.1186/s13287-016-0295-2

Cited by 113 publications

(79 citation statements)

References 82 publications

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“…Due to these advantages, UC-MSCs are being explored as a promising candidate for many potential clinical applications. Recent studies have provided encouraging results regarding the utility of UC-MSCs in several disease models, such as rescuing visual functions in a rodent model of retinal disease14, alleviating neuropathic pain15, protect against experimental colitis16 and treating rat liver fibrosis1718. The use of UC-MSCs as a cellular therapy is currently being explored in clinical trials, including for the treatment of GvHD1920.…”

mentioning

confidence: 99%

Umbilical Cord-derived Mesenchymal Stem Cells Instruct Monocytes Towards an IL10-producing Phenotype by Secreting IL6 and HGF

Deng

Zhang

Ye³

et al. 2016

Sci Rep

123

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Human UC-MSCs are regarded as an attractive alternative to BM-MSCs for clinical applications due to their easy preparation, higher proliferation and lower immunogenicity. However, the mechanisms underlying immune suppression by UC-MSCs are still unclear. We studied the mechanism of inhibition by UC-MSCs during the differentiation of monocytes into DCs and focused on the specific source and the role of the involved cytokines. We found that UC-MSCs suppressed monocyte differentiation into DCs and instructed monocytes towards other cell types, with clear decreases in the expression of co-stimulatory molecules, in the secretion of inflammatory factors and in allostimulatory capacity. IL6, HGF and IL10 might be involved in this process because they were detected at higher levels in a coculture system. UC-MSCs produce IL-6 and HGF, and neutralization of IL-6 and HGF reversed the suppressive effect of UC-MSCs. IL10 was not produced by UC-MSCs but was exclusively produced by monocytes after exposure to UC-MSCs, IL-6 or HGF. In summary, we found that the UC-MSC-mediated inhibitory effect was dependent on IL6 and HGF secreted by UC-MSCs and that this effect induced monocyte-derived cells to produce IL10, which might indirectly strengthen the suppressive effect of UC-MSCs.

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confidence: 99%

Umbilical Cord-derived Mesenchymal Stem Cells Instruct Monocytes Towards an IL10-producing Phenotype by Secreting IL6 and HGF

Deng

Zhang

Ye³

et al. 2016

Sci Rep

123

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“…The efficacy of the treatment changes with the administration time and repeats of application of MSCs during an injury [40].…”

Section: Discussionmentioning

confidence: 99%

Effects of Mesenchymal Stromal Cells on the Neuropathic Pain Induced by Chronic Constriction Injury in Rats

Genç¹,

Zibandeh²,

Yıldız³

et al. 2017

J Pain Relief

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Background: Neuropathic pain remains a persistent clinical problem and characterized by mechanical allodynia and heat hyperalgesia. Chronic pain conditions are among the major health problems which are difficult to treat. Bone marrow-derived mesenchymal stromal cells (BMSCs) have generated great interest as an option for cell-based therapy. BMSCs are easy to isolate and expand ex vivo. Clinical studies show that direct injection of BMSCs does not produce side effects as rejection and is well tolerated by the immune system.

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“…38,71,73–77 These physiologic effects can additionally be accentuated with the co-administration of various growth factors, to include brain-derived neutrophic factor, 71 glial cell-line neutrophic factor, 72 and neurotrophin-3. 78 …”

Section: Methodsmentioning

confidence: 99%

The Science and Clinical Applications of Placental Tissues in Spine Surgery

Shaw

Parada

Gloystein

et al. 2018

Global Spine Journal

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Study Design:Narrative literature review.Objectives:Placental tissue, amniotic/chorionic membrane, and umbilical cord have seen a recent expansion in their clinical application in various fields of surgery. It is important for practicing surgeons to know the underlying science, especially as it relates to spine surgery, to understand the rationale and clinical indication, if any, for their usage.Methods:A literature search was performed using PubMed and MEDLINE databases to identify studies reporting the application of placental tissues as it relates to the practicing spine surgeon. Four areas of interest were identified and a comprehensive review was performed of available literature.Results:Clinical application of placental tissue holds promise with regard to treatment of intervertebral disc pathology, preventing epidural fibrosis, spinal dysraphism closure, and spinal cord injury; however, there is an overall paucity of high-quality evidence. As such, evidence-based guidelines for its clinical application are currently unavailable.Conclusions:There is no high-level clinical evidence to support the application of placental tissue for spinal surgery, although it does hold promise for several areas of interest for the practicing spine surgeon. High-quality research is needed to define the clinical effectiveness and indications of placental tissue as it relates to spine surgery.

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Human bone marrow-derived and umbilical cord-derived mesenchymal stem cells for alleviating neuropathic pain in a spinal cord injury model

Cited by 113 publications

References 82 publications

Umbilical Cord-derived Mesenchymal Stem Cells Instruct Monocytes Towards an IL10-producing Phenotype by Secreting IL6 and HGF

Umbilical Cord-derived Mesenchymal Stem Cells Instruct Monocytes Towards an IL10-producing Phenotype by Secreting IL6 and HGF

Effects of Mesenchymal Stromal Cells on the Neuropathic Pain Induced by Chronic Constriction Injury in Rats

The Science and Clinical Applications of Placental Tissues in Spine Surgery

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