Human Buffy Coat in Three-Dimensional Matrix Tissue Cultures and Monolayers

Kalus, M; Ghidoni, John J.; Oneal, Robert M.

doi:10.1159/000162037

Cited by 1 publication

(1 citation statement)

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“…The existence of PB CFU‐Fs with clonogenesis feature and capacity for prolonged passaging was later confirmed by many other investigators [44, , , –48]. But it was suspected that these blood‐borne fibroblast‐like cells might be a result of connective tissue fragment contamination of blood when obtained by the cardiac route [49, –51]. The suspicion of the contamination with endothelial or connective tissue cells during blood collection was soon eliminated by independent experiments conducted in adult male rabbits [47] and adult guinea pig [52], respectively, by comparing the number of fibroblastic colonies in the blood collected by multiple punctures versus fewer or single puncture(s).…”

Section: Introductionmentioning

confidence: 88%

Concise Review: Multipotent Mesenchymal Stromal Cells in Blood

2006

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Peripheral blood-derived multipotent mesenchymal stromal cells circulate in low number. They share, most although not all, of the surface markers with bone marrow-derived multipotent mesenchymal stromal cells, possess diverse and complicated gene expression characteristics, and are capable of differentiating along and even beyond mesenchymal lineages. Although their origin and physio-pathological function are still unclear, their presence in the adult peripheral blood might relate to some interesting but controversial subjects in the field of adult stem cell biology, such as systemic migration of bone marrow-derived multipotent mesenchymal stromal cells and the existence of common hematopoietic-mesenchymal precursors. In this review, current studies/knowledge about peripheral blood-derived multipotent mesenchymal stromal cells is summarized, and the above-mentioned topics are discussed. STEM CELLS 2007;25:69 -77

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