Human Cancer Is a Parasite Spread via Intrusion in Genome

Abstract

The present article is devoted to further development of new paradigm about the biology of human cancer: the hypothesis of parasitic nature, origin and evolution of the phenomenon. The study included integrative reconsidering, and reinterpretation of the make-ups, traits and processes existing both in human and animal cancers. It was demonstrated that human cancer possesses nearly analogous set of traits characteristic of transmissible animal cancer. Undoubted analogies are seen in the prevalence, clinical exposure, progression of disease, origin of causative agents, immune response against invasion and especially in the intrinsic deviations of the leading traits of cancerous cells. Both human and animal cancers are highly exceptional pathogens. But in contrast to contagious animal cancers the cells of of human cancer can not pass between individuals as usual infectious agents. Exhaustive evidence of the parasitic nature and evolutionary origin of human cancer was revealed and interpreted. In contrast to animal cancer formed of solitary cell lineage, human cancer consists of a couple of lineages constructed under different genetic regulations and performed different structural and physiological functions. The complex make-up of cancer composition remains stable over sequential propagation. The subsistence of human cancer regularly includes obligatory interchange of its successive forms. Human cancer possesses its own biological watch and the ability to gobble its victim, transmit via the intrusion of the genome, perform intercommunications within the tumor components and between the dispersed subunits of cancer. Such intrinsic traits characterize human cancer as a primitively structured parasite that can be classified in Class Mammalians, Species Genomeintruder malevolent (G.malevolent).

Toward the Hypothesis of Cancer Xenogamous Origin of and Circle of Life

“…The divergence between normal and cancerous cell clones should begin far before antenatal embryogenesis. The earliest cancerous cells are formed in fetal micro-locations dispersed around the body, in accordance with general rules of the embryonic differentiation of tissues and their dislocations inside the appropriate organs [13].…”

Parasite Subsistence of Human Cancer

“…It is a biological entity adapted, in its evolution, to invade inside of human body and subsist in the genomes of its cells at the expense of stuffs, energy and functions of invaded organism. Over the circle of life, cancer exists sequentially at subcellular, unicellular and multi-cellular forms Rumyantsev [6][7][8]. It spreads between humans has been intruded inside of the genomes of human reproductive cells either of sperms or ova that function as unicellular host of the parasite.…”

“…Earliest cancerous cells are formed fetal micro-locations dispersed around the body in accordance with general rules of embryonic differentiation of tissues and their dislocations inside appropriate organs. Rumyantsev [8].…”

“…The coital way of transmission is also used by human cancer. Unlike the canine venereal tumor, the transmission of human cancer is performed not by tumor cells but by the genomic predecessors of the cancerous cells: the gametes Rumyantsev [8] and Rumyantsev [66]. The invasive agents of human cancers go through many remarkable adaptations that enable this mammalian cell lineage to live as a unicellular pathogen of mammalian origin.…”

Evolutionary adaptations of human cancer for parasitic life

“…Such functionally heterogeneous cell lineages varied with resect to their distinctive structural or physiological func-p Table 1. Successive forms in cancer subsistence (according to [11], updated). tions and potentials.…”