Human CIDEC transgene improves lipid metabolism and protects against high-fat diet–induced glucose intolerance in mice

Gupta, Abhishek; Balakrishnan, Bijinu; Karki, Shakun; Slayton, Mark; Jash, Sukanta; Banerjee, Sutapa; Grahn, Tan Hooi Min; Jambunathan, Srikarthika; Disney, Sarah; Hussein, Hebaallaha; Dong, Ke; Lowell, Bradford B.; Natarajan, Purushothaman; Reddy, Umesh K.; Gokce, Noyan; Sharma, Vishva Mitra; Puri, Vishwajeet

doi:10.1016/j.jbc.2022.102347

Cited by 14 publications

(3 citation statements)

References 66 publications

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“…Similarly, a transgenic mouse model, in which human FSP27 was overexpressed in the adipose tissue, protected against high‐fat diet‐induced glucose intolerance and lowered levels of triglycerides, cholesterol, and low‐density lipoproteins compared to their littermate controls when fed a high‐fat diet. This suggests that Fsp27 is a potential druggable target to reverse obesity‐induced lipotoxicity and glucose intolerance 101 . Interfering with the expression or function of lipid droplet‐associated perilipins that affect the biogenesis of lipid droplets and various aspects of lipid homeostasis may offer additional viable targets for intervention in the pathogenesis of MASLD.…”

Section: Potential Therapeutic Implicationsmentioning

confidence: 99%

“…This suggests that Fsp27 is a potential druggable target to reverse obesity-induced lipotoxicity and glucose intolerance. 101 Interfering with the expression or function of lipid droplet-associated perilipins that affect the biogenesis of lipid droplets and various aspects of lipid homeostasis may offer additional viable targets for intervention in the pathogenesis of MASLD.…”

Section: Potential Therapeutic Implicationsmentioning

confidence: 99%

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Perilipins: A family of five fat‐droplet storing proteins that play a significant role in fat homeostasis

Chandrasekaran,

Weiskirchen,

Weiskirchen

2024

J of Cellular Biochemistry

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Lipid droplets are organelles with unique spherical structures. They consist of a hydrophobic neutral lipid core that varies depending on the cell type and tissue. These droplets are surrounded by phospholipid monolayers, along with heterogeneous proteins responsible for neutral lipid synthesis and metabolism. Additionally, there are specialized lipid droplet‐associated surface proteins. Recent evidence suggests that proteins from the perilipin family (PLIN) are associated with the surface of lipid droplets and are involved in their formation. These proteins have specific roles in hepatic lipid droplet metabolism, such as protecting the lipid droplets from lipase action and maintaining a balance between lipid storage and utilization in specific cells. Metabolic dysfunction‐associated steatotic liver disease (MASLD) is characterized by the accumulation of lipid droplets in more than 5% of the hepatocytes. This accumulation can progress into metabolic dysfunction‐associated steatohepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma. The accumulation of hepatic lipid droplets in the liver is associated with the progression of MASLD and other diseases such as sarcopenic obesity. Therefore, it is crucial to understand the role of perilipins in this accumulation, as these proteins are key targets for developing novel therapeutic strategies. This comprehensive review aims to summarize the structure and characteristics of PLIN proteins, as well as their pathogenic role in the development of hepatic steatosis and fatty liver diseases.

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Section: Potential Therapeutic Implicationsmentioning

confidence: 99%

Section: Potential Therapeutic Implicationsmentioning

confidence: 99%

Perilipins: A family of five fat‐droplet storing proteins that play a significant role in fat homeostasis

Chandrasekaran,

Weiskirchen,

Weiskirchen

2024

J of Cellular Biochemistry

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“…Fibrates [ 128 ], Niacin [ 129 ] and Fish oil [ 126 , 130 , 131 ], The development of alternatives to statins, which include Evinacumab, the angiotensin-like 2 monoclonal antibody [ 132 ], which has shown adequate safety in trials [ 133 ]. The resurgence of approval for monoclonal antibody treatments for rare disorders [ 134 ] and gene therapy in animal models [ 135 ] will set the direction for the advancement of therapeutics for the management of this emerging disorder.…”

Section: Familial Hypertriglyceridemiamentioning

confidence: 99%

Current Understanding on the Genetic Basis of Key Metabolic Disorders: A Review

Rodrigues

Yong

Bhuiyan

et al. 2022

Biology

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Advances in data acquisition via high resolution genomic, transcriptomic, proteomic and metabolomic platforms have driven the discovery of the underlying factors associated with metabolic disorders (MD) and led to interventions that target the underlying genetic causes as well as lifestyle changes and dietary regulation. The review focuses on fourteen of the most widely studied inherited MD, which are familial hypercholesterolemia, Gaucher disease, Hunter syndrome, Krabbe disease, Maple syrup urine disease, Metachromatic leukodystrophy, Mitochondrial encephalopathy lactic acidosis stroke-like episodes (MELAS), Niemann-Pick disease, Phenylketonuria (PKU), Porphyria, Tay-Sachs disease, Wilson’s disease, Familial hypertriglyceridemia (F-HTG) and Galactosemia based on genome wide association studies, epigenetic factors, transcript regulation, post-translational genetic modifications and biomarker discovery through metabolomic studies. We will delve into the current approaches being undertaken to analyze metadata using bioinformatic approaches and the emerging interventions using genome editing platforms as applied to animal models.

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Mechanism of Obesity-Related Lipotoxicity and Clinical Perspective

Engin

2024

Advances in Experimental Medicine and Biology

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Human CIDEC transgene improves lipid metabolism and protects against high-fat diet–induced glucose intolerance in mice

Cited by 14 publications

References 66 publications

Perilipins: A family of five fat‐droplet storing proteins that play a significant role in fat homeostasis

Perilipins: A family of five fat‐droplet storing proteins that play a significant role in fat homeostasis

Current Understanding on the Genetic Basis of Key Metabolic Disorders: A Review

Mechanism of Obesity-Related Lipotoxicity and Clinical Perspective

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