Human diploid cell rabies vaccine purified by zonal centrifugation: a controlled study of antibody response and side effects following primary and booster pre-exposure immunizations

Fishbein, Daniel B.; Dreesen, David W.; Holmes, Dorothy F.; Pacer, Richard E.; Ley, Allyn B.; Yager, Pamela A.; Sumner, John W.; Reid-Sanden, F L; Sanderlin, Dane W.; Tong, Tony C.; Kemp, Douglas T.

doi:10.1016/0264-410x(89)90159-x

Cited by 37 publications

(10 citation statements)

References 15 publications

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“…Thirty-two studies compared ID immunisation to SC immunisation, and two studies compared ID immunisation to both. The majority of studies was conducted on influenza (n = 5 1) [39–89], HBV (n = 43) [ 17 , [90] , [131] ] and rabies (n = 37) [ 14 , 15 , [132] , [133] , [134] , [135] , [136] , [137] , [138] , [139] , [140] , [141] , [142] , [143] , [144] , [145] , [146] , [147] , [148] , [149] , [150] , [151] , [152] , [153] , [154] , [155] , [156] , [157] , [158] , [159] , [160] , [161] , [162] , [163] , [164] , [165] , [166] ] vaccines. The remaining studies were conducted on IPV [ [167] , [168] , [169] , [170] , [171] , [172] , [173] ], measles [ 10 , [174] , [175] , [176] , [177] , [178] ], hepatitis A (HAV) [ [179] , [180] , [181] , [182] ], diphtheria-tetanus-pertussis (DTP) [ 183 , 184 ], Japanese encephalitis (JE) [ 185 ,…”

Section: Resultsmentioning

confidence: 99%

“…A total of 37 studies were conducted on rabies vaccines [ 14 , 15 , [132] , [133] , [134] , [135] , [136] , [137] , [138] , [139] , [140] , [141] , [142] , [143] , [144] , [145] , [146] , [147] , [148] , [149] , [150] , [151] , [152] , [153] , [154] , [155] , [156] , [157] , [158] , [159] , [160] , [161] , [162] , [163] , [164] , [165] , [166] ]. Since we only considered licensed and available vaccines in this review, only human diploid cell vaccines (HDCV), purified Vero cell rabies vaccines (PVRV) and purified chick embryo cell vaccines (PCECV) were included.…”

Section: Resultsmentioning

confidence: 99%

“…Participants of pre-exposure prophylaxis (PrEP) studies were immune naïve predominantly healthy adults. Twenty-two PrEP studies compared ID to IM immunisation [ 14 , 136 , [138] , [139] , [140] , [143] , [144] , [145] , [146] , [147] , [149] , [150] , [151] , [153] , [154] , [155] , 157 , 158 , [161] , [162] , [163] , 166 ]; two studies [ 132 , 141 ] compared ID to SC immunisation, and one study [ 15 ] compared ID with both IM and SC immunisation. ID doses consisted of either one injection of 0.1 ml or, in eight studies [ [143] , [144] , [145] , [146] , 160 , [164] , [165] , [166] ], of multiple injections of 0.1 ml.…”

Section: Resultsmentioning

confidence: 99%

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Fractional dose of intradermal compared to intramuscular and subcutaneous vaccination - A systematic review and meta-analysis

Schnyder

Pijper

Garrido

et al. 2020

Travel Medicine and Infectious Disease

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Background Vaccine supply shortages are of global concern. We hypothesise that intradermal (ID) immunisation as an alternative to standard routes might augment vaccine supply utilisation without loss of vaccine immunogenicity and efficacy. Methods We conducted a systematic review and meta-analysis searching Medline, Embase and Web of Science databases. Studies were included if: licensed, currently available vaccines were used; fractional dose of ID was compared to IM or SC immunisation; primary immunisation schedules were evaluated; immunogenicity, safety data and/or cost were reported. We calculated risk differences (RD). Studies were included in meta-analysis if: a pre-defined immune correlate of protection was assessed; WHO-recommend schedules and antigen doses were used in the control group; the same schedule was applied to both ID and control groups (PROSPERO registration no. CRD42020151725). Results The primary search yielded 5,873 articles, of which 156 articles were included; covering 12 vaccines. Non-inferiority of immunogenicity with 20–60% of antigen used with ID vaccines was demonstrated for influenza (H1N1: RD -0·01; 95% CI -0·02, 0·01; I 2 = 55%, H2N3: RD 0·00; 95% CI -0·01, 0·01; I 2 = 0%, B: RD -0·00; 95% CI -0·02, 0·01; I 2 = 72%), rabies (RD 0·00; 95% CI -0·02, 0·02; I 2 = 0%), and hepatitis B vaccines (RD -0·01; 95% CI -0·04, 0·02; I 2 = 20%). Clinical trials on the remaining vaccines yielded promising results, but are scarce. Conclusions There is potential for inoculum/antigen dose-reduction by using ID immunisation as compared to standard routes of administration for some vaccines (e.g. influenza, rabies). When suitable, vaccine trials should include an ID arm.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Fractional dose of intradermal compared to intramuscular and subcutaneous vaccination - A systematic review and meta-analysis

Schnyder

Pijper

Garrido

et al. 2020

Travel Medicine and Infectious Disease

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“…This decreases the cost of vaccination and allows for more effi cient use of available vaccine when there are vaccine shortages. 148 Proper training of personnel administering intradermal vaccination is critical. 146 Duration of immunity is a potential concern.…”

Section: Postexposure P Rophylaxis ( Pep )mentioning

confidence: 99%

Viral Diseases

Weese

Fulford

2010

Companion Animal Zoonoses

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“…Rabies PEP is expensive and not without risk of adverse reactions (Fishbein et al 1989). Typically, increases in animal rabies result in increases in numbers of PEPs, and frequently rabies control programs aimed at reducing rabies in wildlife must be justified on the basis of potential cost savings.…”

Section: Control and Preventionmentioning

confidence: 99%

Mammalian reservoirs and the changing epidemiology of rabies in the United States

Childs¹,

Krebs²,

Rupprecht³

1998

vertebrate_pest_conference

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The epidemiology of rabies in the United States has changed dramatically over the past few decades.Greater than 90% of all animal rabies cases reported annually to the Centers for Disease Control and Prevention now occur in wildlife, whereas before 1960 the majority were domestic animals. The principal rabies reservoirs today are wild carnivores and bats, infected with many different types of rabies virus variants. Annual reporting of human deaths have fallen from more than 100 at the turn of the century to one to six per year, despite major outbreaks of animal rabies in several distinct geographic areas. Most recent human rabies cases acquired in the United States are the result of infection with rabies virus variants associated with bats, although the exact incident leading to exposure has been difficult to define. Many recent deaths have occurred in persons who failed to seek post-exposure treatment, presumably because they did not recogniu a risk in the animal contact leading to the infection or failed to recognize that contact had occurred. Although these human rabies deaths are rare, estimated public health costs associated with disease detection, prevention, and control have risen, exceeding millions of dollars each year.

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Human diploid cell rabies vaccine purified by zonal centrifugation: a controlled study of antibody response and side effects following primary and booster pre-exposure immunizations

Cited by 37 publications

References 15 publications

Fractional dose of intradermal compared to intramuscular and subcutaneous vaccination - A systematic review and meta-analysis

Fractional dose of intradermal compared to intramuscular and subcutaneous vaccination - A systematic review and meta-analysis

Viral Diseases

Mammalian reservoirs and the changing epidemiology of rabies in the United States

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