Human embryonic stem cell-derived neural precursor transplants in collagen scaffolds promote recovery in injured rat spinal cord

Hatami, Maryam; Mehrjardi, Nargess Zare; Kiani, Sahar; Hemmesi, Katayoun; Azizi, Hossein; Shahverdi, Abdolhossein; Baharvand, Hossein

doi:10.1080/14653240903005802

Cited by 96 publications

(83 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Section: Polymersmentioning

confidence: 99%

“…Collagen signals its biological actions through α1β1 (monomers) and α2β1 (fibrils) integrins [29] as well as discoidin domain receptors and glycoprotein Vi [30] . in nervous tissue regeneration, collagen has been used in scaffolds [31,32] , magneticallyaligned fibrils [33][34][35][36] , gels [34,37] , and cell-delivery vehicles [38] .Collagen has the innate ability to form magneticallyresponsive fibrils which are capable of directing neurite growth and delivering growth factors, both of which can be advantages for spinal cord repair. However, if the mechanical properties are not properly tuned for the environment, collagen may act as a physical barrier for regenerating growth cones [39] .…”

mentioning

confidence: 99%

“…instead, it is combined with other supportive materials to enhance growth promotion [35,39,52,53] and cell differentiation [54] . Recently, it was shown that the [86] iHC [31,32,38] Bladder function [31,32] BBB [87] inclined plane [87] Walking movements [40] Reflexive behaviors [40] Climbing ability [40] Electrophysiology [40] BBB [49,88] Combined behavior score [88] iHC [49,88] Robotic recording [88] Von Frey filaments [89] iHC [62,[89][90][91] Horizontal ladder [91] Beamwalk [91] BBB [70,71,92] inclined plane [70] Von Frey [70] iHC [70,92,93] Electrophysiology [70,72] Structural MRi [70] BBB [85,94,95] iHC [85,94,95] Electrophysiology …”

mentioning

confidence: 99%

See 2 more Smart Citations

Biomaterials for spinal cord repair

Haggerty

Oudega

2013

Neurosci. Bull.

View full text Add to dashboard Cite

Spinal cord injury (SCi) results in permanent loss of function leading to often devastating personal, economic and social problems. A contributing factor to the permanence of SCi is that damaged axons do not regenerate, which prevents the re-establishment of axonal circuits involved in function. Many groups are working to develop treatments that address the lack of axon regeneration after SCi. The emergence of biomaterials for regeneration and increased collaboration between engineers, basic and translational scientists, and clinicians hold promise for the development of effective therapies for SCi. A plethora of biomaterials is available and has been tested in various models of SCi. Considering the clinical relevance of contusion injuries, we primarily focus on polymers that meet the specific criteria for addressing this type of injury. Biomaterials may provide structural support and/or serve as a delivery vehicle for factors to arrest growth inhibition and promote axonal growth. Designing materials to address the specific needs of the damaged central nervous system is crucial and possible with current technology. Here, we review the most prominent materials, their optimal characteristics, and their potential roles in repairing and regenerating damaged axons following SCi.Keywords: spinal cord injury; axon regeneration; biodegradable materials; extracellular matrix proteins; functional recovery; growth factor; guidance; injury and repair; spinal motor neuron IntroductionSpinal cord injury (SCi) causes loss of neurons and axons resulting in motor and sensory function impairments. There are thousands of new cases of SCi in the world annually [1,2] occurring often in young adults. The lack of endogenous repair and the significant costs to the individual, family and society [1] are important motivations behind the continuing efforts to develop effective therapies. Promoting axonal regeneration is considered a potential repair strategy because it could lead to recovery of axonal circuits involved in motor and/or sensory function [3] .The central nervous system (CNS) neurons are intrinsically capable of some regeneration of damaged axons [4] but their attempts after SCi are frustrated by structural and chemical obstructions in the damaged nervous tissue [5] . Spinal cord repair approaches typically lead to small functional gains. one feature that most of these approaches have in common is a poor axonal regeneration response, suggesting that promoting axonal regeneration, including synapse formation, is essential to achieve substantial functional repair after SCi. if so, it is rational to anticipate that effective spinal cord therapies will need to include interventions addressing the axon growth-inhibition that leads to the poor axonal growth responses. As introduced above, axonal regeneration is considered an important repair mechanism for the injured spinal cord. Therefore, this review focuses on materials that have shown most promise to elicit an axonal regeneration response to foster functional restoration after ...

show abstract

Section: Polymersmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Biomaterials for spinal cord repair

Haggerty

Oudega

2013

Neurosci. Bull.

View full text Add to dashboard Cite

show abstract

“…Due to their biocompatibility, relative abundance and commercial availability, and ease of processing, Iranian researchers extensively used natural scaffold in their studies [21,22,46,69]. Hatami and colleagues investi-gated generation of hESC-derived neural precursor as neural-like tubes in adherent and feeder-free hESC.…”

Section: Pre-made Porous Scaffolds For Cell Seedingmentioning

confidence: 99%

“…Recently Iranian researchers have extensively used scaffolds for TE [19][20][21][22][23]. Long-term goals of Iranian researchers are to engineer tissue grafts for application in regenerative medicine, develop enabling technologies for stem cell research, and design high-fidelity models for studies of tissue development, remodeling, and disease.…”

Section: To Presentmentioning

confidence: 99%

Status of tissue engineering and regenerative medicine in Iran and related advanced tools: Bioreactors and scaffolds

Gharravi¹,

Orazizadeh²,

Hashemitabar³

et al. 2012

JBiSE

View full text Add to dashboard Cite

show abstract

Advances in 3D Bioprinting for Neural Tissue Engineering

et al. 2018

View full text Add to dashboard Cite

Current therapies for nerve regeneration within injured tissues have had limited success due to complicated neural anatomy and inhibitory barriers in situ. Recent advancements in 3D bioprinting technologies have enabled researchers to develop novel 3D scaffolds with complex architectures in an effort to mitigate the challenges that beset reliable and defined neural tissue regeneration. Among several possible neuroregenerative treatment approaches that are being explored today, 3D bioprinted scaffolds have the unique advantage of being highly modifiable, which promotes greater resemblance to the native biological architecture of in vivo systems. This high architectural similarity between printed constructs and in vivo structures is thought to facilitate a greater capacity for repair of damaged nerve tissues. In this review, advances of several 3D bioprinting methods are introduced, including laser bioprinting, inkjet bioprinting, and extrusion‐based printing. In addition, the emergence of 4D printing is discussed, which adds a dimension of transformation over time to traditional 3D printing. Finally, an overview of emerging trends in advanced bioprinting materials is provided and their therapeutic potential for application in neural tissue regeneration is evaluated in both the central nervous system and the peripheral nervous system.

show abstract

Human embryonic stem cell-derived neural precursor transplants in collagen scaffolds promote recovery in injured rat spinal cord

Cited by 96 publications

References 49 publications

Biomaterials for spinal cord repair

Biomaterials for spinal cord repair

Status of tissue engineering and regenerative medicine in Iran and related advanced tools: Bioreactors and scaffolds

Advances in 3D Bioprinting for Neural Tissue Engineering

Contact Info

Product

Resources

About