Human Emotions on the Onset of Cardiovascular and Small Vessel Related Diseases

Vlachakis, Chrisanthy; Dragoumani, Konstantina; Raftopoulou, Sofia; Mantaiou, Meropi; Papageorgiou, Louis; Tsaniras, Spyridon Champeris; Megalooikonomou, Vasileios; Vlachakis, Dimitriοs

doi:10.21873/invivo.11320

Cited by 16 publications

(13 citation statements)

References 122 publications

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“…Recently, a study from the Add Health database performed path analysis linking adverse childhood experiences with later CVE risk but did not study negative emotions (Doom et al, 2017). Previous studies have also shown that improving emotional intelligence may reverse cardiac risk (Vlachakis et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Longitudinal association between adolescent negative emotions and adulthood cardiovascular disease risk: an opportunity for healthcare quality improvement

Srinivas

Anand

Chockalingam

2020

BIJ

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PurposeWhile cardiovascular disease (CVD) is the leading cause of death globally, over 80% of the cases could be prevented through early lifestyle changes. From the perspective of quality management in healthcare, this may offer an effective prevention window if modifiable CVD risk factors are identified and treated in adolescence. The purpose of this research is to examine the negative emotions in adolescents and determine if it independently increases CVD risk later in life.Design/methodology/approachLongitudinal data from 12,350 participants of the Add Health study, which conducted a multi-wave survey for 14 years from adolescence (Wave 1) through adulthood (Wave 4), were used to test the research hypothesis. Four items (perception of life, self-reported depression, perceived loneliness and fearfulness) reflective of adolescent negative emotion were identified from the Wave 1 questionnaire, and factor analysis was conducted to confirm the hypothesized structure. The outcome variable, 30-year adulthood CVD risk category (high or low risk), was estimated using biomarkers, biological data and other factors collected during the 14-year follow-up in Wave 4. A logistic regression analysis was employed to assess the impact of adolescent negative emotions on adulthood CVD risk after adjusting for common risk factors such as sociodemographic characteristics, socioeconomic status and medical conditions in adolescence.FindingsThe results indicated adolescent negative emotion to be significantly associated with CVD risk category (p-value < 0.0001), even after controlling for common risk factors. A unit increase in the level of adolescent negative emotion increased the chance of being in the high CVD risk group in adulthood by 8% (odds ratio = 1.08 ± 0.03).Practical implicationsHealthcare providers and organizations could capitalize on the research findings by screening for negative emotions early in life through individual and societal interventions. The findings also provide an opportunity for implementing quality improvement initiatives to deliver robust preventive care, which, in turn, could improve the overall population health, reduce healthcare costs and improve care quality.Originality/valueAlthough previous studies showed a strong link between adolescent physiological factors (e.g. obesity) and adulthood cardiovascular disease (CVD), the association between adolescent outlook/attitude (negative emotion) and CVD risk has not been examined.

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Section: Discussionmentioning

confidence: 99%

Longitudinal association between adolescent negative emotions and adulthood cardiovascular disease risk: an opportunity for healthcare quality improvement

Srinivas

Anand

Chockalingam

2020

BIJ

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“…In addition to these factors, many authors refer to the evidence of professional stress as a no less important factor and others identifies stress as being almost always present in the manifestations of cardiovascular disease, and emotional stress [8,9].…”

Section: Resultsmentioning

confidence: 99%

The patient-centered care for patients with acute myocardial infarction: what can be improved the disease management

Santos¹,

Pequito²,

Fonseca³

2022

Neuro Neurosci

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Introduction: Cardiovascular diseases are presented as a set of diseases that affect the cardiovascular system because of inappropriate lifestyles or unhealthy, they are consistent in risk might be modifiable through a proper disease management factor. Aim: Assess the perceptions of patients with acute myocardial infarction about this heart disease and risk factors associated. Also, identify the risk factors that can be improved to manage the disease. Design: Observational and prospective study. Methods: The survey was conducted in a Cardiac Intensive Care Unit of a Central Hospital, with inclusion of all patients admitted on a period of two months. Nineteen patients were studied with a clinical diagnosis of Acute Myocardial Infarction. Results: The analysis of the questionnaires showed that, approach the subject has a justified and reasoned relevance. The high prevalence of risk factors that can be modified highlighted the need for intervention in patients with non-modifiable risk factors. Conclusion: Patients with acute myocardial infarction do not have a correct perception of the disease and associated factors. Many of the risk factors present in patients with acute myocardial infarction are likely to be modified by an appropriate disease management, with a patient-centred care.

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“…The structural analysis of the TBK1 protein has been performed using the available human crystal structures (PDB 5W5V and 6NT9) of the TBK1 and it co-crystalized ligands with the MOE software (52). All the extracted conserved motifs from the previous steps, they have been identified and marked in the studied crystal structures (Figure 2 and 4).…”

Section: Structural Analysismentioning

confidence: 99%

An updated evolutionary and structural study of TBK1 reveals highly conserved motifs as potential pharmacological targets in neurodegenerative diseases

Papageorgiou

Mangana

Papakonstantinou

et al. 2022

Preprint

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TANK binding kinase 1 protein (TBK1) is a kinase that belongs to the IκB (IKK) family. TBK1, also known as T2K, FTDALS4, NAK, IIAE8 and NF-κB, is responsible for the phosphorylation of the amino acid residues Serine and Threonine. This enzyme is involved in various key biological processes, including interferon activation and production, homeostasis, cell growth, autophagy, insulin production and the regulation of TNF-α, IFN-β and IL-6. Mutations in the TBK1 gene alter the protein’s normal function and may lead to an array of pathological conditions, including disorders of the Central Nervous System. The present study sought to elucidate the role of the TBK1 protein in Amyotrophic Lateral Sclerosis (ALS), a human neurodegenerative disorder. A broad evolutionary and phylogenetic analysis of TBK1 was performed across numerous organisms to distinguish conserved regions important for the protein’s function. Subsequently, mutations and SNPs were explored and their potential effect on the enzyme’s function was investigated. These analytical steps, in combination with the study of the secondary, tertiary, and quaternary structure of TBK1, enabled the identification of conserved motifs, which can function as novel pharmacological targets and inform therapeutic strategies for Amyotrophic Lateral Sclerosis.

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Human Emotions on the Onset of Cardiovascular and Small Vessel Related Diseases

Cited by 16 publications

References 122 publications

Longitudinal association between adolescent negative emotions and adulthood cardiovascular disease risk: an opportunity for healthcare quality improvement

Longitudinal association between adolescent negative emotions and adulthood cardiovascular disease risk: an opportunity for healthcare quality improvement

The patient-centered care for patients with acute myocardial infarction: what can be improved the disease management

An updated evolutionary and structural study of TBK1 reveals highly conserved motifs as potential pharmacological targets in neurodegenerative diseases

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