Human Endometrial Stromal Cells and Decidual Cells Express Cluster of Differentiation (CD) 13 Antigen/Aminopeptidase N and CD1O Antigen/Neutral Endopeptidase1

Imai, Kimitoshi; Maeda, Masako; Fujiwara, Hiroshi; Okamoto, Norihiko L.; Kariya, Masatoshi; Emi, Nobuyuki; Takakura, Kenji; Kanzaki, Hideharu; Mori, Takahide

doi:10.1095/biolreprod46.3.328

Cited by 71 publications

(43 citation statements)

References 11 publications

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“…CD10 functions as a cell surface enzyme that acts to reduce cellular response to peptide hormones by regulating local peptide concentration (17). Thus, many hormone-sensitive and peptidesensitive cells and their corresponding neoplasms express CD10 antigen (18 -21), including normal endometrial stroma and ESS (22)(23)(24).…”

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confidence: 99%

Utility of CD10 in Distinguishing between Endometrial Stromal Sarcoma and Uterine Smooth Muscle Tumors: An Immunohistochemical Comparison of 34 Cases

et al. 2001

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Endometrial stromal sarcoma (ESS), uterine cellular leiomyoma (UCL), and uterine leiomyosarcoma (ULS) are composed mainly of spindle cells that express similar antigens such as desmin, smooth muscle actin (SMA), and muscle-specific actin (MSA). The differential diagnosis of an ESS versus a uterine smooth muscle tumor or an extrauterine spindle cell sarcoma can be problematic based solely on clinical presentation, histologic assessment, or routine immunohistochemistry. Recently, we reported that normal endometrium, but not myometrium, as well as five cases of ESS, were positive for CD10. We now report the results of CD10 immunohistochemistry in an additional 11 cases of ESS (total 16 cases), 10 cases of UCL, and nine cases of ULS. CD10 immunoreactivity was detected in 16 of 16 cases of ESS (100%) as compared to only 2 of 10 cases of UCL (20%) and none of nine cases of ULS (0%). We compared the utility of CD10 immunoreactivity with that of desmin, SMA, MSA, estrogen receptor (ER), and inhibin in these tumors. Although the majority of cases of UCL and ULS were positive for SMA, MSA, and desmin, a substantial portion of cases of ESS were also positive for SMA, MSA, and desmin. We conclude that in combination with SMA, MSA, and desmin, CD10 is a useful immunohistochemical marker in the differential diagnosis of ESS versus UCL or ULS.

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confidence: 99%

Utility of CD10 in Distinguishing between Endometrial Stromal Sarcoma and Uterine Smooth Muscle Tumors: An Immunohistochemical Comparison of 34 Cases

et al. 2001

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“…Recent studies have demonstrated that CD10 is expressed in a variety of nonhematopoietic tumors, including renal cell carcinoma (5)(6)(7)(8), transitional cell carcinoma (8), hepatocellular carcinoma (9, 10), gastric and colonic adenocarcinoma (11), prostatic adenocarcinoma (8), rhabdomyosarcomas (8), pancreatic adenocarcinomas (8), solid-pseudopapillary tumor of the pancreas (12), clear cell sarcoma of the kidney (13), glioma (14,15), mediastinal germ cell tumors (16), schwannomas (8), malignant melanomas (8,17), dermatofibroma (17), and dermatofibrosarcoma (17). In addition, CD10 is expressed on endometrial stromal cells (18,19) and thus has been considered useful in making a diagnosis of endometrial stromal sarcoma (ESS; 8, 20 -23), which should be distinguished from cellular leiomyoma or leiomyosarcoma. However, CD10 expression in malignant müllerian mixed tumors (MMMTs) and müllerian adenosarcomas has remained to be clarified.…”

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confidence: 99%

Expression of CD10 in Malignant Müllerian Mixed Tumors and Adenosarcomas: An Immunohistochemical Study

et al. 2002

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CD10 has been demonstrated to be positive in endometrial stromal sarcoma (ESS) and thus is useful in establishing the diagnosis, but its expression in malignant müllerian mixed tumor (MMMT) and müllerian adenosarcoma remains to be clarified. In this study, 12 cases of MMMT (9 uterine, 2 tubal, and 1 metastatic), 6 cases of müllerian adenosarcoma (three corporeal, two cervical, and one tubal), and 7 cases of primary uterine sarcomas had their tissues examined immunohistochemically for expression of CD10, desmin, myoglobin, ␣-smooth muscle actin (SMA), and cytokeratin. Of the primary uterine sarcomas, two were primary rhabdomyosarcomas (one cervical and one corporeal), two were ESSs, two were high-grade leiomyosarcomas, and one was a high-grade endometrial sarcoma. Sarcomatous components in all cases of MMMT and müllerian adenosarcoma, as well as all uterine sarcomas, were positive for CD10, showing moderate to marked staining intensity with varying distribution except in one MMMT, which showed weak and very focal staining. In four MMMTs, three adenosarcomas, and one rhabdomyosarcoma, myoglobinand/or desmin-positive rhabdomyoblastic cells were positive for CD10. The immunoreactivity for CD10 showed the same distribution for ␣-SMA and myoglobin in three and two MMMTs, respectively. In five cases of MMMT, carcinomatous components were focally positive for CD10, and in two cases small populations of round or short spindle cells in sarcomatous components were positive for CD10, ␣-SMA, and cytokeratin (CAM5.2). These results indicate that CD10 expression is not restricted to ESS

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“…These decidual cells were confirmed by enzyme assay to have AP-N-like enzyme activity on their cell surface [34]. The expression of AP-N on endometrial stromal cells is augmented by progesterone in vitro.…”

Section: Expression O F Ap-n In the Endometriummentioning

confidence: 78%

“…In the human endometrium, immunoreactive AP-N was expressed on the endometrial stromal cells and decidual cells throughout the menstrual cycle and the first trimester of pregnancy, but not on the endometrial epithelial cells [34]. The intensity of AP-N expression was changed according to the menstrual cycle.…”

Section: Expression O F Ap-n In the Endometriummentioning

confidence: 97%

Membrane-Bound Cell Surface Peptidases in Reproductive Organs.

et al. 1999

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Human Endometrial Stromal Cells and Decidual Cells Express Cluster of Differentiation (CD) 13 Antigen/Aminopeptidase N and CD1O Antigen/Neutral Endopeptidase1

Cited by 71 publications

References 11 publications

Utility of CD10 in Distinguishing between Endometrial Stromal Sarcoma and Uterine Smooth Muscle Tumors: An Immunohistochemical Comparison of 34 Cases

Utility of CD10 in Distinguishing between Endometrial Stromal Sarcoma and Uterine Smooth Muscle Tumors: An Immunohistochemical Comparison of 34 Cases

Expression of CD10 in Malignant Müllerian Mixed Tumors and Adenosarcomas: An Immunohistochemical Study

Membrane-Bound Cell Surface Peptidases in Reproductive Organs.

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