The study focuses on the impact of human enhancement technologies (HET) on job satisfaction from the human resources (HR) standpoint. It starts with the introduction and history of HET considering the types, cognitive, physical, and emotional booster, and recent developments. The chapter then provides details of the theoretical constructs used in the measurement of job satisfaction, the intrinsic and extrinsic incentive stemming from work, a favourable work environment, and the organizational culture. The consequence of the analyzed augmentation technologies include cognitive ones like brain-computer interface and the impact of memory, attention, and problem-solving on physical enhancements like exoskeletons and prosthetics, and emotional technologies for stress management and well-being.