Human epidermal growth factor receptor 2 neu expression in head and neck squamous cell cancers and its clinicopathological correlation: Results from an Indian cancer center

Abstract

In the current settings, HER2/neu is not found to be a prognostic marker in head-and-neck cancers. Standard immunohistochemistry staining protocols need to be established like in breast cancers to aid uniform reporting and further evaluate the role of this important protooncogene in head-and-neck cancers.

Evaluation of Cyclin D1 and Human Epidermal Growth Factor Receptor 2 Neu Protein Expression in Head and Neck Squamous Cell Carcinoma

“…In the present study, no statistical significance was found between disease-free survival and HER2 neu expression. Studies conducted by Adnan et al [ 10 ] and Vats et al [ 19 ] showed no correlation between disease-free survival and HER2 neu expression; this correlates with the results of the present study. On the contrary, Cavalot et al [ 23 ] proved a significant association between HER2 neu expression and poor disease-free survival.…”

“…In the present study, no significant association was derived between the expression of HER2 neu and overall survival. Similar results were seen in studies conducted by Warren et al [ 25 ] and Vats et al [ 19 ]; however, Cavalot et al [ 23 ] suggested that HER2 neu expression can also be helpful in prognosis as an independent risk factor in HNSCC.…”

“…Other studies in the literature, including those of Vats et al [ 19 ], Mohanapure et al [ 22 ], and Doley et al [ 20 ], showed similar results with no association between HER2 neu expression and lymph node metastases. All five out of 70 cases that were positive for HER2 neu expression belonged to stage III and stage IV carcinoma, and five out of 64 (7.8%), which is identical to the study conducted by Vats et al [ 19 ], with nine out of 40 (22.5%) cases, were of stage III and stage IV carcinomas. However, no positive association was established between the expression of HER2 neu and the stage of the disease.…”

“…This finding was consistent with all other studies conducted on HER2 neu expression in HNSCC. Studies conducted by Adnan et al (79 out of 100 tumors, 79%) [ 10 ], Vats et al (56 out of 70 tumors, 80%) [ 19 ], and Doley et al (33 out of 50 tumors, 66%) [ 20 ] showed more cases with no immunoexpression of HER2 neu in the patients. The findings of all these studies are consistent with the findings of the present study.…”

SPINK7 Expression Changes Accompanied by HER2, P53 and RB1 Can Be Relevant to Predict Oral Squamous Cell Carcinoma at Molecular Level

“…We found SPINK7 up regulated in the highly invasive OSCC group, these results were similar to previous studies describing that SPINK6 was up regulated in highly metastatic tumors 43 . SPINK6 regulate the metastasis via EGFR signaling and their expression levels change during the carcinogenesis 52 .…”