Human epidermal growth factor receptor 2 positive rates in invasive lobular breast carcinoma: The Singapore experience

Kee, Ga-Jing; Tan, Ryan Ying-Cong; Sultana, Rehena; Lee, Joycelyn Jie-Xin; Lian, Weixiang; Yeong, Joe Poh Sheng; Tan, Su-Ming; Lim, Sheow Lei; Tan, Benita Kiat‐Tee; Yap, Yoon Sim; Dent, Rebecca; Wong, Fuh Yong; Lee, Guek-Eng

doi:10.5306/wjco.v11.i5.283

Cited by 3 publications

(1 citation statement)

References 18 publications

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“…Most tumors were grade 2 (n = 473, 68.1%), with 189 (27.2%) being grade 1 and 33 (4.8%) being grade 3. A small proportion of cases were HER2 positive [31 of 679 with data available (4.6%)], which was consistent with prior literature [ 11 ]. The mean follow-up time was 7.4 years [standard deviation (SD) 5.9].…”

Section: Resultssupporting

confidence: 86%

Quantifying hormone receptor status in lobular breast cancer in an institutional series: the relationship between estrogen and progesterone receptor status and outcomes

Clelland¹,

Rothschild²,

Patterson³

et al. 2023

Breast Cancer Res Treat

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Purpose Recent guidelines defined a new reporting category of ER-low-positive breast cancer based on immunohistochemistry (IHC). While low positivity of either hormone receptor is uncommon in invasive lobular carcinoma (ILC), we sought to investigate whether relatively low hormone receptor positivity was associated with tumor characteristics and patient outcomes in a single institutional cohort. Methods We searched an institutional database for cases of stage I-III ILC with available IHC reports. Based on prior published categories in ILC, ER was classified as low, medium, or high as defined by ER staining of 10–69%, 70–89%, and ≥ 90% respectively. PR low and high tumors were defined by < 20%, or ≥ 20% staining respectively. We used chi-squared tests, t-tests, and Cox proportional hazards models to evaluate associations between ER/PR categories and tumor characteristics or disease-free survival (DFS). Results The cohort consisted of 707 ILC cases, with 11% of cases categorized as ER low, 15.1% as medium, and 73.8% as high. The majority (67.6%) were PR high. Patients with ER low/medium expression were significantly younger, and more likely to also have PR low and/or HER2 positive tumors compared to those that were ER high. In a Cox proportional hazards model adjusting for age, stage, grade, pleomorphic histology, and treatment, ER category was not prognostic for DFS, but PR negative and PR low status each had significantly worse DFS compared to PR high status (HR 3.5, 95% CI 1.8–6.7, p < 0.001; and HR 2.0, 95% CI 1.1–3.5, p = 0.015, respectively). Conclusion These findings highlight the relevance of quantifying ER and PR within ILC.

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Section: Resultssupporting

confidence: 86%

Quantifying hormone receptor status in lobular breast cancer in an institutional series: the relationship between estrogen and progesterone receptor status and outcomes

Clelland¹,

Rothschild²,

Patterson³

et al. 2023

Breast Cancer Res Treat

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Evolution of biological features of invasive lobular breast cancer: Comparison between primary tumour and metastases

Aliaga

Sandoval

Trapani

et al. 2023

European Journal of Cancer

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İnvaziv lobüler meme karsinomunun klinik özellikleri ve sağkalim sonuçları

Yılmaz,

Erdiş,

Uçar

et al. 2024

Turkish Journal of Clinics and Laboratory

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Amaç: Bu çalışmada kliniğimize başvuran invaziv lobuler meme kanseri tanılı hastaların klinik özellikleri ve sağkalım sonuçlarını araştırdık. Gereç ve Yöntemler: Cumhuriyet Üniversitesi Onkoloji Merkezi'ne 2007-2019 yılları arasında başvuranlardan invazif lobüler karsinom tanısı alan hastalar retrospektif olarak incelendi.. Bulgular: Çalışmada 1166 invaziv meme kanseri kadın hastanın dosyası incelenmiş ve bunlardan 64’ünün (5,5%) invaziv lobular meme kanseri alt tipinde olduğu tesbit edilmiştir. Tanıda 30 (47%) hastanın evre I-II, 31 (48%) hastanın evre III ve 3 (5%) hastanın ise evre IV olduğu tesbit edilmiştir. Histopatolojik değerlendirmelere göre hastaların 60’nda (94%) estrogen reseptörü (ER) pozitif, 53’ünde (83%) progesterone reseptörü (PR) pozitif, 6’sında (9%) HER2-pozitif olarak tesbit edildi. Yapılan tedaviler değerlendirildiğinde 48 (75%) hastaya modifiye radikal mastektomi, 15 (23%) hastaya meme koruyucu cerrahi uygulanmıştır ve 54 (84%) hastaya adjuvant kemoterapi, 55 (86%) hastaya hormonterapi ve 44 (69%) hastaya radyoterapi verilmiştir. Takipte 14 (22%) hastada metastaz tesbit edilmiş olup metastaza kadar geçen süre medyan 38 (6-76) aydı. Hastaların 5 yıllık genel sağkalım ve event-free survival sırasıyla 80% ve 73%’tü. Sonuçlar: Çalışmamızda invaziv lobuler karsinomlu hastalar çoğunluğunu postmenopozal kadınların oluşturduğu, daha çok ileri evrelerde tanı alan, histopatolojik olarak hormon reseptörü pozitifliği yaygın görülen meme kanseri alt tipini temsil etmektedir.

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Human epidermal growth factor receptor 2 positive rates in invasive lobular breast carcinoma: The Singapore experience

Cited by 3 publications

References 18 publications

Quantifying hormone receptor status in lobular breast cancer in an institutional series: the relationship between estrogen and progesterone receptor status and outcomes

Quantifying hormone receptor status in lobular breast cancer in an institutional series: the relationship between estrogen and progesterone receptor status and outcomes

Evolution of biological features of invasive lobular breast cancer: Comparison between primary tumour and metastases

İnvaziv lobüler meme karsinomunun klinik özellikleri ve sağkalim sonuçları

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